Results 121 to 130 of about 4,338 (207)

H2S-Mediated Protein S-Sulfhydration: A Prediction for Its Formation and Regulation

Molecules, 2017
Protein S-sulfhydration is a newly discovered post-translational modification of specific cysteine residue(s) in target proteins, which is involved in a broad range of cellular functions and metabolic pathways.
Youngjun Ju, Ming Fu, Eric Stokes, Lingyun Wu, Guangdong Yang   +4 more
doaj   +1 more source

The reactive species interactome: evolutionary emergence, biological significance, and opportunities for redox metabolomics and personalized medicine [PDF]

, 2017
SIGNIFICANCE: Oxidative stress is thought to account for aberrant redox homeostasis and contribute to aging and disease. However, more often than not administration of antioxidants is ineffective, suggesting our current understanding of the underlying ...
Alan A. Jackson, Andreas Pasch, Anne Koning, Borsook H, Christopher L. Bianco, David A. Wink, Dhanakoti SN, Gunter G.C. Kuhnle, Harry van Goor, Holmes FL, Horowitz JH, Jon M. Fukuto, Kenneth R. Olson, Martin Feelisch, Miriam M. Cortese-Krott, Moncada S, Peter Nagy, Pizzarello S, Sherman H, Storch KJ, Ueland PM, Wakabayashi Y, Windmueller HG, Windmueller HG, Wootton S, Wächtershäuser G   +25 more
core   +2 more sources

MarR family proteins sense sulfane sulfur in bacteria

mLife
Members of the multiple antibiotic resistance regulator (MarR) protein family are ubiquitous in bacteria and play critical roles in regulating cellular metabolism and antibiotic resistance.
Guanhua Xuan, Luying Xun, Yongzhen Xia
doaj   +1 more source

Versatile roles of cysteine persulfides in tumor biology

Current Opinion in Chemical Biology
Rewiring the transsulfuration pathway is recognized as a rapid adaptive metabolic response to environmental conditions in cancer cells to support their increased cysteine demand and to produce Reactive Sulfur Species (RSS) including hydrogen sulfide (H2S) and cysteine persulfide.
Klaudia Borbényi-Galambos, Ágnes Czikora, Katalin Erdélyi, Péter Nagy   +3 more
openaire   +2 more sources

Thioglucose-derived tetrasulfide, a unique polysulfide model compound

Redox Biology
Polysulfides have received increased interest in redox biology due to their role as the precursors of H2S and persulfides. However, the compounds that are suitable for biological investigations are limited to cysteine- and glutathione-derived ...
Stephen Lindahl, Meg Shieh, Tianli Zhang, Chunyu Guo, Jerome R. Robinson, Tomohiro Sawa, Ming Xian   +6 more
doaj   +1 more source

Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity

Redox Biology
Unfolded protein response (UPR) is activated in cells under endoplasmic reticulum (ER) stress. One sensor protein involved in this response is PERK, which is activated through its redox-dependent oligomerization.
Shin Koike, Hideo Kimura, Yuki Ogasawara
doaj   +1 more source

Abstracts

Cancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
wiley   +1 more source

Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality

Redox Biology
Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related ...
Akira Nishimura, Sunghyeon Yoon, Tetsuro Matsunaga, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Masanobu Morita, Jun Yoshitake, Yuka Unno, Uladzimir Barayeu, Tsuyoshi Takata, Hiroshi Takagi, Hozumi Motohashi, Albert van der Vliet, Takaaki Akaike   +14 more
doaj   +1 more source

Über Persulfide von Aldehyden [PDF]

Journal für Praktische Chemie, 1910
Günther Bugge, Ignaz Bloch
openaire   +1 more source

Late-life fasting imparts resiliency and protein persulfidation

Aging, 2021
Yang, Jie, Sharew, Betemariam, Hine, Christopher   +2 more
openaire   +2 more sources