Results 91 to 100 of about 64,492 (258)

GOUVERNANCE D'ENTREPRISE ET PERTINENCE DES BENEFICES COMPTABLES: UNE ETUDE D'ASSOCIATION

open access: yes, 2005
International audienceCette étude vérifie l'effet de la gouvernance d'entreprise sur la pertinence des bénéfices. La gouvernance est synthétisée en six axes.
Matoussi, Hamadi   +2 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Grammaticalisation, m\ue9tonymie et pertinence

open access: yes, 2008
: Dans cette br\ue8ve contribution, nous nous demandons quel pourrait \ueatre lapport de la th\ue9orie de la pertinence \ue0 lanalyse des \ue9volutions s\ue9mantiques sous-jacentes aux processus de grammaticalisation.
De Mulder, Walter
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Ambiguïté linguistique et pertinence

open access: yes, 2014
Nous allons esquisser une analyse du jeu de mots au point de vue de la théorie de la pertinence, telle qu’elle a été définie et développée par Dan Sperber et Deirdre Wilson à partir de 1986, en adoptant un double point de vue: celui du récepteur ...
F Regattin, REGATTIN, FABIO
core  

الاستدلال اللغوي عند الأصوليين: مقاربة تداولية

open access: yesالفكر الإسلامي المعاصر, 2013
تسعى هذه الدراسة إلى الكشف عن بعض جوانب ثراء تراثنا اللغوي المتصل بقراءة خطاب الوحي وحداثته أيضاً، عبر مقاربته بأحدث التوجّهات التداولية.كما تطمح إلى الوقوف على بعض شرائط القدرتين: الوصفية، والتفسيرية، التي ميَّزت الخطاب الأصولي بوصفه نظرية في تحليل ...
يحيى رمضان
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

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