Results 91 to 100 of about 236,496 (287)

The Pertinence of Incontinence

open access: yesPrincipia: An International Journal of Epistemology, 2005
In this paper I suggest a reconstruction of the traditional concepts of con-tinent and incontinent action. This reconstruction proceeds along the lines of a standpoint of bounded rationality.
António Zilhão
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

L'évaluation de la qualité de la formation et du système d'évaluation universitaire: le point de vue des diplômés

open access: yesAvaliação: Revista da Avaliação da Educação Superior, 2008
Les recherches sur l'évaluation des acquis professionnels des jeunes diplômés (ROMAINVILLE, 2002 ; DE KETELE, 1997, 1999, 2000; FRANCE, 2003) ; Avis du Haut Conseil de l'Evaluation de l'Ecole, 2003) gravitent autour de quatre thèmes : les compétences des
Hallouma Boussada, Jean-Marie De Ketele
doaj   +1 more source

A Challenge Set Approach to Evaluating Machine Translation

open access: yes, 2017
Neural machine translation represents an exciting leap forward in translation quality. But what longstanding weaknesses does it resolve, and which remain?
Cherry, Colin   +2 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Stress corrosion crack inhibiting method for titanium [PDF]

open access: yes, 1970
Addition of oxyanions to liquid solvents in excess of the number of chloride, bromide, or iodide ions present prevents cracking of titanium-aluminum alloys under exposure to aqueous and other solvent environments.
Beck, T. R.
core   +1 more source

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