Results 101 to 110 of about 64,492 (258)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Revue de pertinence des journées d'hospitalisation au centre de soins de suite Henriville à Amiens (état des lieux et étude des causes de pertinence)

open access: yes, 2014
Objectif : Face au vieillissement de la population française, et dans un contexte économique contraint, la pertinence des soins est devenue une priorité de santé publique, et ce notamment au sein des structures de soins de suite et de réadaptation (SSR ...
DHOUDAIN-DEGROOTTE, Josy   +1 more
core  

Le travail du Groupe Langue Orale : Sa pertinence

open access: yes, 1975
H. Mariette. Le travail du Groupe Langue Orale : Sa pertinence. In: Repères pour la rénovation de l'enseignement du français à l'école élémentaire, n°32, 1975. pp.
Houdebine, Anne-Marie
core   +1 more source

Un análisis factorial para evaluar la pertinencia de un programa académico desde la perspectiva de los graduados: un estudio de caso

open access: yesEcos de Economía, 2009
Resumen El presente artículo busca evaluar la pertinencia de un programa académico desde la perspectiva de los graduados a partir de dos modelos. El primer modelo está constituido por dos factores o variables latentes: i) la percepción de los graduados ...
Juan José Vásquez   +2 more
doaj  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Spécialisation, destination et valorisation. Pertinence des méthodes

open access: yes, 2005
Robine François. Spécialisation, destination et valorisation. Pertinence des méthodes. In: Droit et Ville, tome 59, 2005. Colloque : Les baux commerciaux et centres commerciaux (Toulouse, 19 novembre 2004) - Colloque : Les assises du logement étudiant à ...
Robine, François
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

Pertinence Logic for Reasoning about Actions and Change

open access: yes, 1997
We discuss a new approach to dealing with causality in reasoning about actions and change. First, we introduce the logic of pertinence L 2 to describe knowledge over a static domain --especially the causal influences.
Ramon P. Otero
core  

Pertinence des examens cardiologiques en consultation pré anesthésique

open access: yes, 2020
INTRODUCTION : La gestion des risques cardiaques en anesthésie reste un défi quotidien dans la pratique de l’anesthésie. Des recommandations nationales publiées sont disponibles pour optimiser la prise en charge des patients dans un contexte de dépenses ...
Beaubert, Aurélien
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

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