Results 101 to 110 of about 51,251 (208)
Conservation and global distribution of non-canonical antigens in enterotoxigenic Escherichia coli [PDF]
, 2019 BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) cause significant diarrheal morbidity and mortality in children of resource-limited regions, warranting development of effective vaccine strategies.
Boxrud, Dave +14 more
core +2 more sources
Nurr1 Orchestrates Claustrum Development and Functionality
Advanced Science, Volume 13, Issue 13, 3 March 2026.Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan +12 more
wiley +1 more source
Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans [PDF]
, 1991 A cDNA corresponding to a known G protein alpha subunit, the alpha subunit of Go (Go alpha), was isolated and sequenced. The predicted amino acid sequence of C. elegans Go alpha is 80-87% identical to other Go alpha sequences.
Lochrie, Michael A. +3 more
core +1 more source
Molecular cloning of pertussis toxin genes
Nucleic Acids Research, 1986 We have cloned a 4.5 kb EcoRI/BamHI DNA fragment from Bordetella pertussis which contains at least two genes responsible for expression of pertussis toxin. The S4 subunit of the toxin was isolated by high pressure liquid chromatography and the NH2-terminal amino acid sequence determined. Using a mixed synthetic oligonucleotide probe designed by reverse
C, Locht +6 more
openaire +3 more sources
CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.Trigonelline alleviates traumatic brain injury (TBI) by attenuating oxidative stress and neuroinflammation. It inhibits MAPK signaling–mediated neuronal apoptosis and reduces cerebral edema via downregulation of AQP4 and MMP‐9, thereby maintaining blood–brain barrier integrity.
Qian Zhang +7 more
wiley +1 more source
Experimental Biology and Medicine, 1933 Mishulow, Mowry and Scott1 demonstrated that exotoxic filtrates could be obtained from whooping cough cultures. They planted their organisms on chocolate agar over which they had poured a small amount of horse serum-beef heart broth. The small amount of diluent made the harvest of toxin necessarily small. On the other hand, Craster and Smith2 mentioned
J. A. Toomey, J. E. McClelland
openaire +1 more source
Molecular aspects of Bordetella pertussis pathogenesis [PDF]
, 2010 The molecular mechanisms of Bordetella virulence are now well understood, and many virulence factors have been identified and characterized at the molecular level.
Camille Locht
core +2 more sources
Construction of Minitransposons for Constitutive and Inducible Expression of Pertussis Toxin in Bvg-Negative Bordetella-Bronchiseptica [PDF]
, 1991 Appropriately detoxified pertussis toxin (PT) of Bordetella pertussis is considered to be an essential component of new-generation whooping cough vaccines, but the development of a procedure to obtain high levels of purified toxin has been and continues ...
Rohde, Manfred +3 more
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Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements [PDF]
, 2010 Label-free biosensor technology based on dynamic mass redistribution (DMR) of cellular constituents promises to translate GPCR signaling into complex optical 'fingerprints' in real time in living cells.
Blattermann, S +16 more
core +1 more source
Recent advances and challenges in antigen engineering & vaccine development [PDF]
, 2014 textVaccines play a vital role in public health by preventing infectious disease across the globe. Vaccine formulations represent a weakened form of a microbe or toxin that is injected into the human body to elicit an immune response, generating ...
Kornahrens, William Joseph
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