Results 111 to 120 of about 18,673,205 (171)

Xenotransplantation of the Porcine Lung—From Immunological Barriers to Emerging Experimental Strategies

Xenotransplantation, Volume 33, Issue 5, September/October 2026.
ABSTRACT Lung transplantation is the only long‐lasting life‐saving treatment for patients with end‐stage pulmonary disease, but the ever‐growing shortage of suitable donor organs leads to high mortality rates of the afflicted patients. Xenotransplantation, the transplantation of organs across species, has emerged as a promising alternative. This review
Nathalie Roters, Niveditha Varma, Robert Ramm, Heiner Niemann, Patrick Zardo, Arjang Ruhparwar, Tobias Goecke   +6 more
wiley   +1 more source

Études moléculaires et structurales - d’un nouveau mode de dimérisation des intégrases rétrovirales pour développer des modulateurs d’oligomérisation ET - de l’intégrase porcine de PERV-A/C en complexe avec son cofacteur cellulaire humain Brd2 dans un contexte de xénotransplantatio

, 2017
Integrase (IN) is an essential enzyme in retroviral replicative cycle, which catalyzes the integration of the viral DNA into the target cell genome. Structural data previously obtained by our team led to rational design of molecules likely to block IN in
Yajjou, Halima
core   +1 more source

PERV genetic characteristics as selective breeding criteria - developing a pig breed suitable for xenotransplantation

, 2011
Full text is available to authenticated members of The University of Auckland only.The risk of a zoonotic infection by porcine endogenous retrovirus (PERV) has been a major impediment to the xenotransplantation field ever since the discovery that PERV ...
Wynyard, Shaun
core  

Ryhiner-Kartensammlung / 1 Perv

Titel- und Massstabskartusche oben linksFranzösischer Text auf der Kartenrückseite ("Description de Perv.")Osten obenSeitennumerierung (Rückseite): "721", "724" (oben), "Xxxxxxxx" (unten)Ursprungswerk: "Atlas ou representation du monde universel, et des ...
Jansson, Jan
core   +1 more source

Genomic Validation of PERV-C-Free Pigs to Support Xenotransplantation. [PDF]

Xenotransplantation
Benjamin NR, Madrigal G, Ishida Y, Catchen J, Allen KL, Pepin B, Roca AL.   +6 more
europepmc   +1 more source

Molecular and structural studies of a novel dimerization model of retroviral integrases for oligomerization modulators development AND PERV-A/C porcine integrase complexed to its human cellular cofactor Brd2 in a xenotransplantation context

, 2017
L'intégrase (IN) est une enzyme essentielle du cycle réplicatif des rétrovirus, qui catalyse l'intégration de l'ADN viral rétrotranscrit dans le génome de la cellule cible.
Yajjou, Halima
core  

Progress of transgenic pigs in liver xenotransplantation. [PDF]

Liver Res
Xie XM, Wang GY.
europepmc   +1 more source

Global Consultation for Clinical Xenotransplantation: International Xenotransplantation Association Consensus and Communiqué Update. [PDF]

Xenotransplantation
Hawthorne WJ, Wolf E, Cowan PJ, Wang W, Yun IJ, Brenner P, Korbutt G, Meier RPH, Sykes M, Bühler LH, Scobie L, Garkavenko O, Kim H, Hurst DJ, Iii RNP, Rieben R, Pascual M, Scholes-Robertson N, Cozzi E, Abalovich A, Loupy A, Hara H, Bottino R, Ekser B, Mohiuddin MM, Fishman J.   +25 more
europepmc   +1 more source

Further Evidence for the Immunosuppressive Activity of Transmembrane Envelope Protein p15E of Porcine Endogenous Retrovirus. [PDF]

Int J Mol Sci
Denner J, Schwinzer R, Pokoyski C, Kaufer BB, Dierkes B, Ban J, Lovlesh L.   +6 more
europepmc   +1 more source

Cloning of PERV-env in GXBM minipig and analysis of its tissue expression profile

, 2017
目的克隆广西巴马小型猪PERV-env部分基因,并研究其在不同组织中的表达差异。方法利用RT-PCR方法从巴马小型猪外周血白细胞中扩增PERV-env基因,并与部分国内外已发表的PERV-env基因序列进行同源性及遗传进化分析。以扩增获得的广西巴马小型猪PERV-env基因为模板设计引物,利用半定量RT-PCR的方法对广西巴马小型猪不同组织中PERV mRNA表达情况进行分析。结果在所检测的9个组织样品中PERV mRNA相对表达水平存在差异,肾及外周血淋巴细胞中PERV mRNA丰度最高,肺、心、肝 ...
马玲, 廖艳娟, 唐海波, 陈凤莲, 吴健敏, 潘汉世, 龙寒, 钟华   +7 more
core