Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells [PDF]
Frontiers in Microbiology, 2018 The xenotransplantation of porcine tissues may help overcome the shortage of human organs for transplantation. However, there are some concerns about recipient safety because the risk of porcine endogenous retrovirus (PERV) transmission to human cells ...
Krzysztof Łopata +5 more
doaj +5 more sources
Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein [PDF]
mBio, 2022 Retroviral elements from endogenous retroviruses have functions in mammalian physiology. The best-known examples are the envelope proteins that function in placenta development and immune suppression.
Trevor T. Dean +2 more
doaj +5 more sources
Reducing porcine corneal graft rejection, with an emphasis on porcine endogenous retrovirus transmission safety: a review [PDF]
International Journal of Ophthalmology, 2019 Donor cornea shortage is a primary hurdle in the development of corneal transplantation. Of all species, porcine corneas are the ideal transplantation material for humans.
Yao-Wen Song, Zhi-Qiang Pan
doaj +4 more sources
Efficient and Safe Editing of Porcine Endogenous Retrovirus Genomes by Multiple-Site Base-Editing Editor [PDF]
Cells, 2022 Gene-modified miniature pigs serve as alternative tissue and organ donors for xenotransplantation to alleviate the shortage of human allogenic organs.
Shuwen Zheng +11 more
doaj +3 more sources
Susceptibility of porcine endogenous retrovirus to anti‐retroviral inhibitors [PDF]
Xenotransplantation, 2016 AbstractBackgroundPorcine endogenous retrovirus (PERV) is an endogenous retrovirus that poses a risk of iatrogenic transmission in the context of pig‐to‐human xenotransplantation. The lack of a means to control PERV infection in the context of pig‐to‐human xenotransplantation is a major concern in the field.
Argaw T, Colon-Moran W, Wilson C.
exaly +5 more sources
Can Antiretroviral Drugs Be Used to Treat Porcine Endogenous Retrovirus (PERV) Infection after Xenotransplantation? [PDF]
Viruses, 2017 Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs; they are released as infectious particles, and under certain conditions they can infect human cells. Therefore, they represent a risk when pigs are used as sources of cells,
Joachim Denner
doaj +4 more sources
Detection of non-reference porcine endogenous retrovirus loci in the Vietnamese native pig genome [PDF]
Scientific Reports, 2022 The Vietnamese native pig (VnP)—a porcine breed with a small body—has proven suitable as a biomedical animal model. Here, we demonstrate that, compared to other breeds, VnPs have fewer copies of porcine endogenous retroviruses (PERVs), which pose a risk ...
Shinya Ishihara +7 more
doaj +2 more sources
Screening and Identification of the First Non-CRISPR/Cas9-Treated Chinese Miniature Pig With Defective Porcine Endogenous Retrovirus pol Genes [PDF]
Frontiers in Immunology, 2022 Pig to human xenotransplantation is considered to be a possible approach to alleviate the shortage of human allografts. Porcine endogenous retrovirus (PERV) is the most significant pathogen in xenotransplantation.
Yuyuan Ma +16 more
doaj +2 more sources
Transmission of Porcine Endogenous Retrovirus Produced from Different Recipient Cells In Vivo. [PDF]
PLoS ONE, 2016 Humanized pigs have been developed to reduce the incidence of immune rejection in xenotransplantation, but significant concerns remain, such as transmission of viral zoonosis. Porcine endogenous retroviruses (PERV), which exist in the genome of pigs, are
Nayoung Kim +7 more
doaj +2 more sources
No Evidence of Infection with Porcine Endogenous Retrovirus in Recipients of Encapsulated Porcine Islet Xenografts [PDF]
Cell Transplantation, 2000 Transplantation of pig tissues into humans has the potential for cotransferring pig infections. Knowledge of the epidemiology of pig infections transmissible to humans allows the development of risk limitation strategies at the source herd level, but ...
R. B. Elliott +8 more
doaj +3 more sources