Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein [PDF]
mBio, 2022 Retroviral elements from endogenous retroviruses have functions in mammalian physiology. The best-known examples are the envelope proteins that function in placenta development and immune suppression.
Trevor T. Dean +2 more
doaj +5 more sources
Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine [PDF]
Virology Journal, 2006 The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a ...
Wilkinson Robert +2 more
doaj +6 more sources
Transmission of Porcine Endogenous Retrovirus Produced from Different Recipient Cells In Vivo. [PDF]
PLoS ONE, 2016 Humanized pigs have been developed to reduce the incidence of immune rejection in xenotransplantation, but significant concerns remain, such as transmission of viral zoonosis. Porcine endogenous retroviruses (PERV), which exist in the genome of pigs, are
Nayoung Kim +7 more
doaj +6 more sources
Efficient and Safe Editing of Porcine Endogenous Retrovirus Genomes by Multiple-Site Base-Editing Editor [PDF]
Cells, 2022 Gene-modified miniature pigs serve as alternative tissue and organ donors for xenotransplantation to alleviate the shortage of human allogenic organs.
Shuwen Zheng +11 more
doaj +2 more sources
Detection of non-reference porcine endogenous retrovirus loci in the Vietnamese native pig genome [PDF]
Scientific Reports, 2022 The Vietnamese native pig (VnP)—a porcine breed with a small body—has proven suitable as a biomedical animal model. Here, we demonstrate that, compared to other breeds, VnPs have fewer copies of porcine endogenous retroviruses (PERVs), which pose a risk ...
Shinya Ishihara +7 more
doaj +2 more sources
Reducing porcine corneal graft rejection, with an emphasis on porcine endogenous retrovirus transmission safety: a review [PDF]
International Journal of Ophthalmology, 2019 Donor cornea shortage is a primary hurdle in the development of corneal transplantation. Of all species, porcine corneas are the ideal transplantation material for humans.
Yao-Wen Song, Zhi-Qiang Pan
doaj +2 more sources
Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells [PDF]
Frontiers in Microbiology, 2018 The xenotransplantation of porcine tissues may help overcome the shortage of human organs for transplantation. However, there are some concerns about recipient safety because the risk of porcine endogenous retrovirus (PERV) transmission to human cells ...
Krzysztof Łopata +5 more
doaj +2 more sources
Screening and Identification of the First Non-CRISPR/Cas9-Treated Chinese Miniature Pig With Defective Porcine Endogenous Retrovirus pol Genes [PDF]
Frontiers in Immunology, 2022 Pig to human xenotransplantation is considered to be a possible approach to alleviate the shortage of human allografts. Porcine endogenous retrovirus (PERV) is the most significant pathogen in xenotransplantation.
Yuyuan Ma +16 more
doaj +2 more sources
Characterization of porcine endogenous retrovirus insertion in Jeju native pigs and commercial breeds [PDF]
Animal BioscienceObjective This study aimed to characterize the genomic distribution and amino acid homology of porcine endogenous retrovirus (PERV) subtypes in three pig breeds, Jeju native pigs (JNPs), Duroc, and Landrace.
Seungwon Yoon +9 more
doaj +2 more sources
Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species [PDF]
Retrovirology, 2007 Background The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host range of retroviruses.
Takeuchi Yasuhiro +2 more
doaj +3 more sources