Results 41 to 50 of about 7,153 (189)
EXISTENCE OF PROVIRAL PORCINE ENDOGENOUS RETROVIRUS IN FRESH AND DECELLULARISED PORCINE TISSUES
Indian Journal of Medical Microbiology, 2008 Swine are expected to be utilized as xenograft donors for both whole organ and cellular transplantation. A major concern in using porcine organs for transplantation is the potential of transmission of porcine endogenous retrovirus (PERV). Tissue-engineered or decellularised heart valves have already been implanted in humans and have been marketed by ...
Prabha, S, Verghese, S
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Cell Transplantation, 2004 The discovery of porcine endogenous retroviruses (PERV) has raised concerns regarding the safety of porcine xenotransplantation. However, transmission of PERV had not been observed in humans exposed to porcine tissue.
Brice W. Mckane +5 more
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Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate? [PDF]
, 2017 Cardiac xenotransplantation (CXTx) is a promising solution to the chronic shortage of donor hearts. Recent advancements in immune suppression have greatly improved the survival of heterotopic CXTx, now extended beyond 2 years, and life-supporting kidney ...
Byrne, GW, McGregor, CGA
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Molecular and Enzymatic Characterization of the Porcine Endogenous Retrovirus Protease [PDF]
Journal of Virology, 2002 ABSTRACT The protease of the porcine endogenous retrovirus (PERV) subtypes A/B and C was recombinantly expressed in Escherichia coli as proteolytically active enzyme and characterized. The PERV Gag precursor was also recombinantly produced and used as the substrate in an in vitro enzyme assay in parallel ...
Jürgen H, Blusch +2 more
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Cell Transplantation, 2000 Transplantation of pig tissues into humans has the potential for cotransferring pig infections. Knowledge of the epidemiology of pig infections transmissible to humans allows the development of risk limitation strategies at the source herd level, but ...
R. B. Elliott +8 more
doaj +1 more source
Viruses, 2015 Transcriptome analysis of polar bear (Ursus maritimus) tissues identified sequences with similarity to Porcine Endogenous Retroviruses (PERV). Based on these sequences, four proviral copies and 15 solo long terminal repeats (LTRs) of a newly described ...
Kyriakos Tsangaras +3 more
doaj +1 more source
Examining the potential for porcine-derived islet cells to harbour viral pathogens [PDF]
, 2018 With an onus on safety in the potential use of porcine islet cells as a treatment for diabetes, the use of animals lacking exogenous pathogens is clearly important and multilevel screening strategies have been presented on testing animals and the product.
Crossan, Claire +4 more
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Susceptibility of Human Liver Cells to Porcine Endogenous Retrovirus
Experimental and Clinical Transplantation, 2013 The risk of porcine endogenous retrovirus infection is a major barrier for pig-to-human xenotransplant. Porcine endogenous retrovirus, present in porcine cells, can infect many human and nonhuman primate cells in vitro, but there is no evidence available about in vitro infection of human liver cells.
Xinzi, Lin +8 more
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Cellular xenotransplantation of animal cells into people: benefits and risk [PDF]
, 2018 The main benefit of xenotransplantation is its potential to overcome the worldwide organ shortage experienced in allotransplantation. Allogeneic transplantation is the only successful therapy for several life-threatening diseases, with cell, tissue or ...
Cozzi, Emanuele +4 more
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Polymerase chain reaction in detection of porcine endogenous retrovirus (PERV) from porcine tissues [PDF]
Indian Journal of Microbiology, 2009 Pigs offer an unlimited source of xenografts for humans. The use of transplants from animal origin offers a potential solution to the limited supply of human organs and tissues. However, like many other mammalian species, pigs harbor porcine endogenous retrovirus (PERV), which are encoded in their genomic DNA and are assumed to have been integrated ...
M Suji, Prabha, Susan, Verghese
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