Bridging a Patient with Acute Liver Failure to Liver Transplantation by the AMC-Bioartificial Liver
Cell Transplantation, 2003 Recently a phase I clinical trial has been started in Italy to bridge patients with acute liver failure (ALF) to orthotopic liver transplantation (OLT) by the AMC-bioartificial liver (AMC-BAL).
Maarten-Paul Van De Kerkhove +12 more
doaj +1 more source
Encapsulated and ‘free’ pig islet xenotransplantation: recent experience and clinical progress* [PDF]
CellR4, 2019 Genetically-engineered pigs offer a possible alternative to deceased human donors as a source of isolated islets for transplantation into patients with life-threatening diabetes.
D. Cooper, R. Bottino
doaj +1 more source
Knock-in of Enhanced Green Fluorescent Protein or/and Human Gene into Gene Locus in the Porcine Fibroblasts to Produce Therapeutic Protein [PDF]
Asian-Australasian Journal of Animal Sciences, 2014 Transgenic animals have become important tools for the production of therapeutic proteins in the domestic animal. Production efficiencies of transgenic animals by conventional methods as microinjection and retrovirus vector methods are low, and the ...
Sang Mi Lee +9 more
doaj +1 more source
The ethics of xenotransplantation [PDF]
, 2000 Xenotransplantation - moving organs from one species to another - is currently being actively researched as a possible contribution to the problem of a global shortage of human organs for transplants.
Reiss, Michael
core +3 more sources
The MeLiM Minipig: An Original Spontaneous Model to Explore Cutaneous Melanoma Genetic Basis
Frontiers in Genetics, 2017 Melanoma is the deadliest skin cancer and is a major public health concern with a growing incidence worldwide. As for other complex diseases, animal models are needed in order to better understand the mechanisms leading to pathology, identify potential ...
Emmanuelle Bourneuf, Emmanuelle Bourneuf
doaj +1 more source
Xenotransplantation: past, present, and future [PDF]
, 2017 PURPOSE OF REVIEW: To review the progress in the field of xenotransplantation with special attention to most recent encouraging findings which will eventually bring xenotransplantation to the clinic in the near future.
Cooper, David K.C. +2 more
core +1 more source
Selective human cells in vitro transduction with porcine endogenous retrovirus (PERV)
Acta virologica, 2022 Porcine xenograft transplantation raises concerns in humans about the risk of infection with porcine endogenous retroviruses (PERV) as they are an integral part of the pig genome and are therefore very difficult to exclude. In this study, for the first time, a relationship between the provirus genes sequences and released virions from pig cell line and
Sabina, Gałka +2 more
openaire +3 more sources
Ancient origin and complex evolution of porcine endogenous retroviruses
Biosafety and Health, 2020 Porcine endogenous retroviruses (PERVs) are proviruses that have medical value in xenotransplantation. However, the evolutionary process leading to the generation of modern PERVs is not well understood.
Yicong Chen +3 more
doaj +1 more source
Interferon-lambda: A potent regulator of intestinal viral infections [PDF]
, 2017 Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and ...
Baldridge, Megan T, Lee, Sanghyun
core +3 more sources
Monitoring swine virus transmission in embryos derived from commercial abattoir oocytes
Frontiers in Veterinary SciencePigs are pivotal in agriculture and biomedical research and hold promise for xenotransplantation. Specific-pathogen-free (SPF) herds are essential for commercial swine production and xenotransplantation research facilities.
Brent Pepin +4 more
doaj +1 more source