Viruses, 2015 Transcriptome analysis of polar bear (Ursus maritimus) tissues identified sequences with similarity to Porcine Endogenous Retroviruses (PERV). Based on these sequences, four proviral copies and 15 solo long terminal repeats (LTRs) of a newly described ...
Kyriakos Tsangaras +3 more
doaj +1 more source
Molecular evolution of the porcine type I interferon family: subtype-specific expression and antiviral activity. [PDF]
PLoS ONE, 2014 Type I interferons (IFNs), key antiviral cytokines, evolve to adapt with ever-changing viral threats during vertebrate speciation. Due to novel pathogenic pressure associated with Suidae speciation and domestication, porcine IFNs evolutionarily engender ...
Yongming Sang +2 more
doaj +1 more source
Susceptibility of the Porcine Endogenous Retrovirus to Reverse Transcriptase and Protease Inhibitors [PDF]
Journal of Virology, 2001 ABSTRACT Porcine xenografts may offer a solution to the shortage of human donor allografts. However, all pigs contain the porcine endogenous retrovirus (PERV), raising concerns regarding the transmission of PERV and the possible development of disease in xenotransplant recipients. We evaluated 11 antiretroviral drugs licensed for
S H, Qari +7 more
openaire +2 more sources
Bridging a Patient with Acute Liver Failure to Liver Transplantation by the AMC-Bioartificial Liver
Cell Transplantation, 2003 Recently a phase I clinical trial has been started in Italy to bridge patients with acute liver failure (ALF) to orthotopic liver transplantation (OLT) by the AMC-bioartificial liver (AMC-BAL).
Maarten-Paul Van De Kerkhove +12 more
doaj +1 more source
Encapsulated and ‘free’ pig islet xenotransplantation: recent experience and clinical progress* [PDF]
CellR4, 2019 Genetically-engineered pigs offer a possible alternative to deceased human donors as a source of isolated islets for transplantation into patients with life-threatening diabetes.
D. Cooper, R. Bottino
doaj +1 more source
Porcine Endogenous Retrovirus Risks and Ethical Reconstruction of Xenotransplantation
Yixue yu zhexuePigs are considered excellent donors for xenotransplantation, but porcine endogenous retrovirus (PERV) constitutes a fundamental uncertainty due to its endogenous nature, recombination potential, and unpredictable interactions with the human immune ...
Hongyu CHEN, Song LI
doaj +1 more source
Knock-in of Enhanced Green Fluorescent Protein or/and Human Gene into Gene Locus in the Porcine Fibroblasts to Produce Therapeutic Protein [PDF]
Asian-Australasian Journal of Animal Sciences, 2014 Transgenic animals have become important tools for the production of therapeutic proteins in the domestic animal. Production efficiencies of transgenic animals by conventional methods as microinjection and retrovirus vector methods are low, and the ...
Sang Mi Lee +9 more
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Susceptibility of Human Liver Cells to Porcine Endogenous Retrovirus
Experimental and Clinical Transplantation, 2013 The risk of porcine endogenous retrovirus infection is a major barrier for pig-to-human xenotransplant. Porcine endogenous retrovirus, present in porcine cells, can infect many human and nonhuman primate cells in vitro, but there is no evidence available about in vitro infection of human liver cells.
Xinzi, Lin +8 more
openaire +2 more sources
The MeLiM Minipig: An Original Spontaneous Model to Explore Cutaneous Melanoma Genetic Basis
Frontiers in Genetics, 2017 Melanoma is the deadliest skin cancer and is a major public health concern with a growing incidence worldwide. As for other complex diseases, animal models are needed in order to better understand the mechanisms leading to pathology, identify potential ...
Emmanuelle Bourneuf, Emmanuelle Bourneuf
doaj +1 more source
Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing
Animal Research and One Health, EarlyView.Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley +1 more source