Results 71 to 80 of about 521,449 (181)

Analysis of PERV-C superinfection resistance using HA-tagged viruses

Retrovirology, 2023
Background Using pigs as organ donors has advanced xenotransplantation to the point that it is almost ready for clinical use. However, there is still a zoonotic risk associated with xenotransplantation, and the potential transmission of porcine ...
Merle Flecks, Nicole Fischer, Jacomina Krijnse Locker, Ralf R. Tönjes, Antonia W. Godehardt   +4 more
doaj   +1 more source

The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo, Li Li, Fang Wang, Wen Liu, Yan Zhang   +4 more
wiley   +1 more source

Microbiological safety of a novel bio-artificial liver support system based on porcine hepatocytes: a experimental study

European Journal of Medical Research, 2012
Background Our institute has developed a novel bio-artificial liver (BAL) support system, based on a multi-layer radial-flow bioreactor carrying porcine hepatocytes and mesenchymal stem cells.
Han Bing, Shi Xiao-lei, Zhang Yue, Chu Xue-hui, Gu Jin-yang, Xiao Jiang-qiang, Ren Hao-zhen, Tan Jia-jun, Gu Zhong-ze, Ding Yi-tao   +9 more
doaj   +1 more source

Advancing Type 1 Diabetes Treatment: 3 PM‐Oriented Innovations in Islet Transplantation and Biomaterial Engineering

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Fatemeh Sabet Sarvestani, Ramin Yaghobi, Mohsen Khosravi Maharlooei, Mehdi Golshan, Mohammad Hossein Karimi   +4 more
wiley   +1 more source

Genomic Presence of Recombinant Porcine Endogenous Retrovirus in Transmitting Miniature Swine

, 2020
The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a ...
Martin, Stanley I, Fishman, Jay, Wilkinson, Robert   +2 more
core   +1 more source

Artificial Intelligence in Xenotransplantation: A Prioritized Roadmap for Early Clinical Translation, Opportunities and Challenges

Xenotransplantation, Volume 33, Issue 5, September/October 2026.
ABSTRACT Xenotransplantation represents a potential solution to the persistent global organ shortage, yet its clinical application remains stalled by complex immunologic responses, coagulation dysregulation, species‐specific biology, and infectious risks.
Kasra Shirini, Zoe Hahn, Joseph M. Ladowski, Alexander Schulick, Saghar Babadi, Alexandre Loupy, Kazuhiko Yamada, Raphael P. H. Meier   +7 more
wiley   +1 more source

Polymerase chain reaction in detection of porcine endogenous retrovirus (PERV) from porcine tissues [PDF]

Indian Journal of Microbiology, 2009
Pigs offer an unlimited source of xenografts for humans. The use of transplants from animal origin offers a potential solution to the limited supply of human organs and tissues. However, like many other mammalian species, pigs harbor porcine endogenous retrovirus (PERV), which are encoded in their genomic DNA and are assumed to have been integrated ...
M Suji, Prabha, Susan, Verghese
openaire   +2 more sources

Application of Methods Detecting Xenotransplantation-Relevant Viruses for Screening German Slaughterhouse Pigs

Viruses
Detection methods have been developed to prevent transmission of zoonotic or xenozoonotic porcine viruses after transplantation of pig organs or cells to the recipient (xenotransplantation).
Hina Jhelum, Benedikt Kaufer, Joachim Denner   +2 more
doaj   +1 more source

Xenotransplantation of the Porcine Lung—From Immunological Barriers to Emerging Experimental Strategies

Xenotransplantation, Volume 33, Issue 5, September/October 2026.
ABSTRACT Lung transplantation is the only long‐lasting life‐saving treatment for patients with end‐stage pulmonary disease, but the ever‐growing shortage of suitable donor organs leads to high mortality rates of the afflicted patients. Xenotransplantation, the transplantation of organs across species, has emerged as a promising alternative. This review
Nathalie Roters, Niveditha Varma, Robert Ramm, Heiner Niemann, Patrick Zardo, Arjang Ruhparwar, Tobias Goecke   +6 more
wiley   +1 more source

Computational Evaluation of the Strict Master and Random Template Models of Endogenous Retrovirus Evolution. [PDF]

PLoS ONE, 2016
Transposable elements (TEs) are DNA sequences that are able to replicate and move within and between host genomes. Their mechanism of replication is also shared with endogenous retroviruses (ERVs), which are also a type of TE that represent an ancient ...
Fabrícia F Nascimento, Allen G Rodrigo
doaj   +1 more source