Results 81 to 90 of about 521,449 (181)

Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice [PDF]

Journal of Clinical Investigation, 2004
Porcine endogenous retrovirus (PERV) is a potential pathogen in clinical xenotransplantation; transmission of PERV in vivo has been suggested in murine xenotransplantation models. We analyzed the transmission of PERV to human cells in vivo using a model in which immunodeficient NOD/SCID transgenic mice were transplanted with porcine and human ...
Yong-Guang, Yang, James C, Wood, Ping, Lan, Robert A, Wilkinson, Megan, Sykes, Jay A, Fishman, Clive, Patience   +6 more
openaire   +2 more sources

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, Volume 4, Issue 3, Page 347-351, August 2026.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

Xenotransplantation at a Crossroads: Breakthroughs, Challenges, and the Path Forward

Organ Medicine, EarlyView.
Xiaoyu Gan, Jizhang Yu, Jie Wu, Junjie Zong   +3 more
wiley   +1 more source

Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy

Molecular Reproduction and Development, Volume 93, Issue 8, August 2026.
ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley   +1 more source

Comprehensive Protocols for Detecting Xenotransplantation-Relevant Viruses

Methods and Protocols
Xenotransplantation using pig cells, tissues, or organs is advancing toward clinical application to address the shortage of human donor organs for treating organ failure.
Hina Jhelum, Benedikt B. Kaufer, Joachim Denner   +2 more
doaj   +1 more source

Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A stepwise translational framework linking natural‐product discovery, computational prioritisation, experimental validation, lead optimisation and targeted delivery is proposed to advance antiviral design. ABSTRACT The COVID‐19 pandemic highlighted the role of rapid viral mutation and global connectivity in accelerating viral emergence and spread ...
Adedayo Ayodeji Lanrewaju, Abimbola Motunrayo Folami, Saheed Sabiu, Feroz Mahomed Swalaha   +3 more
wiley   +1 more source

Porcine Endogenous Retrovirus Transmission Characteristics of an Inbred Herd of Miniature Swine [PDF]

Journal of Virology, 2002
ABSTRACT Here we report the identification of inbred miniature swine that failed to produce human-tropic replication-competent porcine endogenous retroviruses (HTRC PERVs), using in vitro coculture assays. When HTRC PERVs were isolated from transmitting animals, all were recombinant viruses, with the receptor-binding domain of PERV-A ...
Beth A, Oldmixon, James C, Wood, Thomas A, Ericsson, Carolyn A, Wilson, Mary E, White-Scharf, Goran, Andersson, Julia L, Greenstein, Henk-Jan, Schuurman, Clive, Patience   +8 more
openaire   +2 more sources

Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR‐Based β‐Cell Replacement and Treg Immune Modulation Approaches

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5476-5491, July 2026.
ABSTRACT Background Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease marked by the destruction of pancreatic β‐cells, resulting in lifelong dependence on exogenous insulin. Despite advances in insulin delivery and glucose monitoring technologies, patients remain at risk for acute and long‐term complications, underscoring the need for ...
Tzu‐Min Lin, Hui‐Fang Chang, Tzu‐Ching Lin, Cheng‐Han Lin, Yu‐Ling Sun, Chih‐Sheng Lin   +5 more
wiley   +1 more source

Ethical Considerations in Islet Xenotransplantation

Xenotransplantation, Volume 33, Issue 4, July/August 2026.
ABSTRACT For the management of type 1 diabetes, islet xenotransplantation has emerged as a potential alternative to lifelong insulin therapy or islet allotransplantation. However, this progress raises significant ethical questions that warrant further exploration.
Daniel J. Hurst, Alexa Tarzy, Christopher A. Bobier, Luz A. Padilla, Johannes Kögel, Anthony Merlocco, Raphael P. H. Meier   +6 more
wiley   +1 more source

Functional hierarchy of two L domains in porcine endogenous retrovirus (PERV) that influence release and infectivity [PDF]

, 2008
The porcine endogenous retrovirus (PERV) Gag protein contains two late (L) domain motifs, PPPY and P(F/S)AP. Using viral release assays we demonstrate that PPPY is the dominant L domain involved in PERV release.
Martina, Yuri, Wilson, Carolyn A., Harrison, Frank, Marcucci, Katherine T., Salomon, Daniel R.   +4 more
core   +1 more source