Results 61 to 70 of about 521,449 (181)

Cell entry and exit of porcine endogenous retrovirus A: receptors and release inhibitor [PDF]

, 2010
Following the discovery that porcine endogenous retrovirus (PERV) can infect human cells, the potential risk of a zoonotic infection by PERV has been a major obstacle in the xenotransplantation field.
Mattiuzzo, G.
core  

Transcription of Endogenous Retrovirus Group K Members and Their Neighboring Genes in Chicken Skeletal Muscle Myoblasts [PDF]

, 2021
Skeletal muscle myoblasts are myogenic precursor cells that generate myofibers during muscle development and growth. We recently reported that broiler myoblasts, compared to layer myoblasts, proliferate and differentiate more actively and promptly into ...
Tamao Ono, Ono, Tamao, Hiroshi Kagami, Takaya, Tomohide, Tomohide Takaya, Nihashi, Yuma, Yuma Nihashi, Kagami, Hiroshi   +7 more
core   +1 more source

Ancient origin and complex evolution of porcine endogenous retroviruses

Biosafety and Health, 2020
Porcine endogenous retroviruses (PERVs) are proviruses that have medical value in xenotransplantation. However, the evolutionary process leading to the generation of modern PERVs is not well understood.
Yicong Chen, Mingyue Chen, Xiaoyan Duan, Jie Cui   +3 more
doaj   +1 more source

Genomic evidence of the blood virome and bacteriome provides insights into prevalence, evolution, and susceptibility-related genes across Eurasian pigs

BMC Genomics
Background Infectious diseases are among the primary constraints to pig production, and the globalization of the pig industry has contributed to the emergence and spread of pathogens.
Zhen Liu, Shi-Yu Lu, Si-Jia Ma, Lei Zhou, Wan-Ying Li, Heng Du, Jian-Feng Liu   +6 more
doaj   +1 more source

Monitoring swine virus transmission in embryos derived from commercial abattoir oocytes

Frontiers in Veterinary Science
Pigs are pivotal in agriculture and biomedical research and hold promise for xenotransplantation. Specific-pathogen-free (SPF) herds are essential for commercial swine production and xenotransplantation research facilities.
Brent Pepin, Paula Rodriguez-Villamil, Lauren Sammel, Jie Yin, Brian Dacken   +4 more
doaj   +1 more source

Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5  proteins including human TRIM5 [PDF]

, 2009
The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5{
Takeuchi, Y., Schaller, T., Towers, G. J., Wood, A., Webb, B. L. J., Bartosch, B.   +5 more
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, Volume 600, Issue 17, Page 2579-2614, September 2026.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Detection of Pig Cells Harboring Porcine Endogenous Retroviruses in Non-Human Primate Bladder After Renal Xenotransplantation

Viruses, 2019
Pigs are used as potential donor animals for xenotransplantation. However, porcine endogenous retrovirus (PERV), shown to infect both human and non-human primate (NHP) cells in vitro, presents a risk of transmission to humans in xenotransplantation.
Yoonki Heo, Yeondong Cho, Keon Bong Oh, Ki Hoon Park, Hansam Cho, Hanul Choi, Minjee Kim, Ik Jin Yun, Hee Jung Lee, Young Bong Kim   +9 more
doaj   +1 more source

A highly sensitive method for the detection of recombinant PERV-A/C env RNA using next generation sequencing technologies

Scientific Reports, 2020
Several xenogenic cell-based therapeutic products are currently under development around the world for the treatment of human diseases. Porcine islet cell products for treating human diabetes are a typical example.
Ken Kono, Kiyoko Kataoka, Yuzhe Yuan, Keisuke Yusa, Kazuhisa Uchida, Yoji Sato   +5 more
doaj   +1 more source

The Relationship between Embryonic Development and the Efficiency of Target Mutations in Porcine Endogenous Retroviruses (PERVs) Pol Genes in Porcine Embryos

Animals, 2019
Porcine endogenous retrovirus (PERV) is a provirus found in the pig genome that may act as an infectious pathogen in humans who receive pig organ xenotransplantation.
Maki Hirata, Manita Wittayarat, Takayuki Hirano, Nhien Thi Nguyen, Quynh Anh Le, Zhao Namula, Mokhamad Fahrudin, Fuminori Tanihara, Takeshige Otoi   +8 more
doaj   +1 more source