Results 61 to 70 of about 7,153 (189)

Identification of novel subgroup a variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus [PDF]

, 2012
<b>BACKGROUND:</b> The development of anaemia in feline leukaemia virus (FeLV)-infected cats is associated with the emergence of a novel viral subgroup, FeLV-C.
A Manrique, AJ Phipps, AS McDougall, Brian J Willett, C Chandhasin, C Munk, CP Geret, CS Tailor, D Onions, EA Hoover, Elizabeth L McMonagle, ES Svarovskaia, FL Graham, G Towers, GA Dean, H Chen, Hazel Stewart, J Brojatsch, J Hartikka, JG Quigley, JG Quigley, JI Mullins, JK Brown, Karen W Adema, KS Levesque, L Mackey, LL Bolin, M Gouy, M Reinacher, MA Rey, MA Rigby, MA Stewart, Margaret J Hosie, MM Anderson, N Hussain, N Riedel, N Riedel, NC Pedersen, O Jarrett, O Jarrett, O Jarrett, O Jarrett, O Jarrett, O Jarrett, OB Spiller, PH Russell, PM Rwambo, PR Donahue, PS Sarma, R Mendoza, R Pandey, RL Sheets, S Boomer, S Nakowitsch, T Ohashi, WD Hardy, WD Hardy, WD Hardy, Z Shalev   +58 more
core   +3 more sources

The role of genetically engineered pigs in xenotransplantation research [PDF]

, 2015
There is a critical shortage in the number of deceased human organs that become available for the purposes of clinical transplantation. This problem might be resolved by the transplantation of organs from pigs genetically engineered to protect them from ...
Ayares, David, Cooper, David K.C., Ekser, Burcin, Phelps, Carol, Ramsoondar, Jagdeece   +4 more
core   +1 more source

Packaging of human endogenous retrovirus sequences is undetectable in porcine endogenous retrovirus particles produced from human cells

Virology, 2003
The chronic shortage of human donor organs and tissues for allotransplantation could be relieved if clinical xenotransplantation were to become a viable clinical therapy. Balanced against the benefits of xenotransplantation are the possible consequences of zoonotic infections, and in particular, infection by porcine endogenous retrovirus (PERV).
Suling, Kristen, Quinn, Gary, Wood, James, Patience, Clive   +3 more
openaire   +2 more sources

Potential for clinical pancreatic islet xenotransplantation [PDF]

, 2014
Diabetes mellitus is increasing worldwide. Type 1 diabetes can be treated successfully by islet allotransplantation, the results of which are steadily improving.
Bottino, R, Cooper, DKC, Hara, H, Nagaraju, S, Satyananda, V, Trucco, M, Wijkstrom, M   +6 more
core   +1 more source

Extended Analysis of the In Vitro Tropism of Porcine Endogenous Retrovirus [PDF]

Journal of Virology, 2000
ABSTRACTWe previously reported that mitogenic activation of porcine peripheral blood mononuclear cells resulted in production of porcine endogenous retrovirus(es) (PERV[s]) capable of productively infecting human cells (C. Wilson et al., J. Virol. 72:3082–3087, 1998).
C A, Wilson, S, Wong, M, VanBrocklin, M J, Federspiel   +3 more
openaire   +2 more sources

Detection of Pig Cells Harboring Porcine Endogenous Retroviruses in Non-Human Primate Bladder After Renal Xenotransplantation

Viruses, 2019
Pigs are used as potential donor animals for xenotransplantation. However, porcine endogenous retrovirus (PERV), shown to infect both human and non-human primate (NHP) cells in vitro, presents a risk of transmission to humans in xenotransplantation.
Yoonki Heo, Yeondong Cho, Keon Bong Oh, Ki Hoon Park, Hansam Cho, Hanul Choi, Minjee Kim, Ik Jin Yun, Hee Jung Lee, Young Bong Kim   +9 more
doaj   +1 more source

A highly sensitive method for the detection of recombinant PERV-A/C env RNA using next generation sequencing technologies

Scientific Reports, 2020
Several xenogenic cell-based therapeutic products are currently under development around the world for the treatment of human diseases. Porcine islet cell products for treating human diabetes are a typical example.
Ken Kono, Kiyoko Kataoka, Yuzhe Yuan, Keisuke Yusa, Kazuhisa Uchida, Yoji Sato   +5 more
doaj   +1 more source

Quantitative Estimation of Porcine Endogenous Retrovirus Release from PK15 Cells

Polish Journal of Microbiology, 2012
The present study focuses on the assessment of porcine endogenous retrovirus (PERV) release from PK15 cells in a time dependent manner. The highest amount of PERV A RNA was detected in PK15 cells after 16 hours of culture. The highest amount of PERV B RNA was detected in PK15 cells after 20 hours.
Magdalena, Kimsa, Barbara, Strzalka-Mrozik, Malgorzata, Kimsa, Jolanta, Adamska, Joanna, Gola, Krzysztof, Lopata, Urszula, Mazurek   +6 more
openaire   +2 more sources

The Relationship between Embryonic Development and the Efficiency of Target Mutations in Porcine Endogenous Retroviruses (PERVs) Pol Genes in Porcine Embryos

Animals, 2019
Porcine endogenous retrovirus (PERV) is a provirus found in the pig genome that may act as an infectious pathogen in humans who receive pig organ xenotransplantation.
Maki Hirata, Manita Wittayarat, Takayuki Hirano, Nhien Thi Nguyen, Quynh Anh Le, Zhao Namula, Mokhamad Fahrudin, Fuminori Tanihara, Takeshige Otoi   +8 more
doaj   +1 more source

Analysis of PERV-C superinfection resistance using HA-tagged viruses

Retrovirology, 2023
Background Using pigs as organ donors has advanced xenotransplantation to the point that it is almost ready for clinical use. However, there is still a zoonotic risk associated with xenotransplantation, and the potential transmission of porcine ...
Merle Flecks, Nicole Fischer, Jacomina Krijnse Locker, Ralf R. Tönjes, Antonia W. Godehardt   +4 more
doaj   +1 more source