Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice [PDF]
Journal of Clinical Investigation, 2004 Porcine endogenous retrovirus (PERV) is a potential pathogen in clinical xenotransplantation; transmission of PERV in vivo has been suggested in murine xenotransplantation models. We analyzed the transmission of PERV to human cells in vivo using a model in which immunodeficient NOD/SCID transgenic mice were transplanted with porcine and human ...
Yong-Guang, Yang +6 more
openaire +2 more sources
When should precaution prevail? : interests in (public) health, the risk of harm and xenotransplantation. [PDF]
, 2010 Xenotransplantation is an example of a developing biotechnology which highlights three differing interests in the health of the public; a specific interest in enhancing the health of individuals who require a particular procedure or treatment, a wider ...
Fovargue, Sara, Ost, Suzanne
core +1 more source
Viruses, 2014 Advanced nucleic acid-based technologies are powerful research tools for novel virus discovery but need to be standardized for broader applications such as virus detection in biological products and clinical samples.
Lanyn P. Taliaferro +6 more
doaj +1 more source
Complete genome sequences of two feline Leukemia virus subgroup B isolates with novel recombination sites [PDF]
, 2013 It is generally accepted that all primary isolates of feline leukemia virus (FeLV) contain a subgroup A virus (FeLV-A) that is essential for transmission.
Bae +12 more
core +1 more source
Suboptimal porcine endogenous retrovirus infection in non-human primate cells: implication for preclinical xenotransplantation. [PDF]
PLoS ONE, 2010 BACKGROUND: Porcine endogenous retrovirus (PERV) poses a potential risk of zoonotic infection in xenotransplantation. Preclinical transplantation trials using non-human primates (NHP) as recipients of porcine xenografts present the opportunity to assess ...
Giada Mattiuzzo, Yasuhiro Takeuchi
doaj +1 more source
Xenotransplantation: Perspectives and limits [PDF]
, 2001 Xenotransplantation faces the dilemma of an unlimited supply of cells, tissues and organs on the one hand and severe obstacles and limits on the other. One reason for the limitations is that the source animal of choice, the pig, and the human recipient ...
Hammer, Claus
core +1 more source
An approach to the control of disease transmission in pig-to-human xenotransplantation. [PDF]
, 2000 : Although several major immunologic hurdles need to be overcome, the pig is currently considered the most likely source animal of cells, tissues and organs for transplantation into humans.
A. D. M. E. Osterhaus +57 more
core +4 more sources
Amplification of simian retroviral sequences from human recipients of baboon liver transplants [PDF]
, 1998 Investigations into the use of baboons as organ donors for human transplant recipients, a procedure called xenotransplantation, have raised the specter of transmitting baboon viruses to humans and possibly establishing new human infectious diseases ...
Anonymous +12 more
core +1 more source
Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells. [PDF]
, 2016 Great progress has been made regarding the capabilities to modify somatic cell fate ever since the technology for generation of induced pluripotent stem cells (iPSCs) was discovered in 2006.
Biswas, Sangita +3 more
core +2 more sources
Potential benefits and risks of clinical xenotransplantation [PDF]
, 2012 The transplantation of organs and cells from pigs into humans could overcome the critical and continuing problem of the lack of availability of deceased human organs and cells for clinical transplantation.
Ayares, D, Cooper, DKC
core +2 more sources