Susceptibility of porcine endogenous retrovirus to anti-retroviral inhibitors. [PDF]
Xenotransplantation, 2016 AbstractBackgroundPorcine endogenous retrovirus (PERV) is an endogenous retrovirus that poses a risk of iatrogenic transmission in the context of pig‐to‐human xenotransplantation. The lack of a means to control PERV infection in the context of pig‐to‐human xenotransplantation is a major concern in the field.
Argaw T, Colon-Moran W, Wilson C.
europepmc +6 more sources
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9. [PDF]
Science, 2017 Taking the PERVs out of pigs With the severe shortage of organs needed for transplants, xenotransplantation (transplantation of nonhuman organs to humans) offers an alternative source. Some pig organs have similar size and function to those of humans.
Niu D +22 more
europepmc +7 more sources
Can Antiretroviral Drugs Be Used to Treat Porcine Endogenous Retrovirus (PERV) Infection after Xenotransplantation? [PDF]
Viruses, 2017 Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs; they are released as infectious particles, and under certain conditions they can infect human cells. Therefore, they represent a risk when pigs are used as sources of cells,
Joachim Denner
doaj +2 more sources
Molecular evolution of the porcine type I interferon family: subtype-specific expression and antiviral activity. [PDF]
PLoS ONE, 2014 Type I interferons (IFNs), key antiviral cytokines, evolve to adapt with ever-changing viral threats during vertebrate speciation. Due to novel pathogenic pressure associated with Suidae speciation and domestication, porcine IFNs evolutionarily engender ...
Yongming Sang +2 more
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Cytotoxic Effects during Knock Out of Multiple Porcine Endogenous Retrovirus (PERV) Sequences in the Pig Genome by Zinc Finger Nucleases (ZFN). [PDF]
PLoS One, 2015 Xenotransplantation has been proposed as a solution to the shortage of suitable human donors for transplantation and pigs are currently favoured as donor animals.
Semaan M, Ivanusic D, Denner J.
europepmc +6 more sources
Genomic evidence of the blood virome and bacteriome provides insights into prevalence, evolution, and susceptibility-related genes across Eurasian pigs [PDF]
BMC GenomicsBackground Infectious diseases are among the primary constraints to pig production, and the globalization of the pig industry has contributed to the emergence and spread of pathogens.
Zhen Liu +6 more
doaj +2 more sources
Restriction of porcine endogenous retrovirus by porcine APOBEC3 cytidine deaminases. [PDF]
J Virol, 2011 ABSTRACT Xenotransplantation of porcine cells, tissues, and organs shows promise to surmount the shortage of human donor materials. Among the barriers to pig-to-human xenotransplantation are porcine endogenous retroviruses (PERV) since functional representatives of the two polytropic classes, PERV-A and PERV-B, are able to infect
Dörrschuck E +9 more
europepmc +4 more sources
Regulation of porcine endogenous retrovirus release by porcine and human tetherins. [PDF]
J Virol, 2010 ABSTRACT The risk of transmission of porcine endogenous retrovirus (PERV) is one of the major safety issues in xenotransplantation. Human tetherin, recently described as an antiviral protein able to inhibit the release of enveloped viruses, and its porcine homologue were shown to inhibit PERV release from producer cells, establishing ...
Mattiuzzo G, Ivol S, Takeuchi Y.
europepmc +4 more sources
Vaccination against the Koala Retrovirus (KoRV): Problems and Strategies
Animals, 2021 The koala retrovirus (KoRV) is spreading in the koala population from the north to the south of Australia and is also in the process of endogenization into the koala genome.
Joachim Denner
doaj +1 more source
The restriction of zoonotic PERV transmission by human APOBEC3G. [PDF]
PLoS ONE, 2007 The human APOBEC3G protein is an innate anti-viral factor that can dominantly inhibit the replication of some endogenous and exogenous retroviruses. The prospects of purposefully harnessing such an anti-viral defense are under investigation.
Stefán R Jónsson +5 more
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