Results 11 to 20 of about 521,449 (181)

Restriction of porcine endogenous retrovirus by porcine APOBEC3 cytidine deaminases. [PDF]

J Virol, 2011
ABSTRACT Xenotransplantation of porcine cells, tissues, and organs shows promise to surmount the shortage of human donor materials. Among the barriers to pig-to-human xenotransplantation are porcine endogenous retroviruses (PERV) since functional representatives of the two polytropic classes, PERV-A and PERV-B, are able to infect
Dörrschuck E, Fischer N, Bravo IG, Hanschmann KM, Kuiper H, Spötter A, Möller R, Cichutek K, Münk C, Tönjes RR.   +9 more
europepmc   +5 more sources

EXISTENCE OF PROVIRAL PORCINE ENDOGENOUS RETROVIRUS IN FRESH AND DECELLULARISED PORCINE TISSUES

Indian Journal of Medical Microbiology, 2008
Swine are expected to be utilized as xenograft donors for both whole organ and cellular transplantation. A major concern in using porcine organs for transplantation is the potential of transmission of porcine endogenous retrovirus (PERV). Tissue-engineered or decellularised heart valves have already been implanted in humans and have been marketed by ...
Prabha, S, Verghese, S
core   +5 more sources

Molecular and Enzymatic Characterization of the Porcine Endogenous Retrovirus Protease [PDF]

Journal of Virology, 2002
ABSTRACT The protease of the porcine endogenous retrovirus (PERV) subtypes A/B and C was recombinantly expressed in Escherichia coli as proteolytically active enzyme and characterized. The PERV Gag precursor was also recombinantly produced and used as the substrate in an in vitro enzyme assay in parallel ...
Jürgen H, Blusch, Sigrid, Seelmeir, Klaus, von der Helm   +2 more
openaire   +3 more sources

Characterization of porcine endogenous retrovirus insertion in Jeju native pigs and commercial breeds [PDF]

Animal Bioscience
Objective This study aimed to characterize the genomic distribution and amino acid homology of porcine endogenous retrovirus (PERV) subtypes in three pig breeds, Jeju native pigs (JNPs), Duroc, and Landrace.
Seungwon Yoon, Mrinmoy Ghosh, Myeongyeon Shin, Hyunyong Choi, Cheol-Ho Hyun, Dae Cheol Kim, Shin Ji Lee, Min Jee An, Young-Ok Son, Chang-Gi Hur   +9 more
doaj   +2 more sources

Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine [PDF]

Virology Journal, 2006
The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a ...
Wilkinson Robert, Martin Stanley I, Fishman Jay A   +2 more
doaj   +5 more sources

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9. [PDF]

Science, 2017
Taking the PERVs out of pigs With the severe shortage of organs needed for transplants, xenotransplantation (transplantation of nonhuman organs to humans) offers an alternative source. Some pig organs have similar size and function to those of humans.
Niu D, Niu D, Wei HJ, Lin L, George H, Wang T, Lee IH, Zhao HY, Wang Y, Kan Y, Shrock E, Lesha E, Wang G, Luo Y, Qing Y, Jiao D, Zhao H, Zhou X, Wang S, Wei H, Güell M, Church GM, Church GM, Yang L.   +23 more
europepmc   +4 more sources

Heart valves from pigs and the porcine endogenous retrovirus: Experimental and clinical data to assess the probability of porcine endogenous retrovirus infection in human subjects [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2001
Replacement of heart valves in human subjects has become a routine procedure in cardiac operations. We sought to investigate whether commercially available glutaraldehyde-fixed porcine heart valve prostheses cause porcine endogenous retrovirus infection in human subjects because recent studies revealed that human cells can be infected with porcine ...
Moza, A.K., Mertsching, H., Herden, T., Bader, A., Haverich, A.   +4 more
openaire   +4 more sources

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology [PDF]

Health Care Sci
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Saha S, Dutta M, Bosu A.
europepmc   +2 more sources

Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species [PDF]

Retrovirology, 2007
Background The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host range of retroviruses.
Takeuchi Yasuhiro, Matouskova Magda, Mattiuzzo Giada   +2 more
doaj   +2 more sources

Regulation of porcine endogenous retrovirus release by porcine and human tetherins. [PDF]

J Virol, 2010
ABSTRACT The risk of transmission of porcine endogenous retrovirus (PERV) is one of the major safety issues in xenotransplantation. Human tetherin, recently described as an antiviral protein able to inhibit the release of enveloped viruses, and its porcine homologue were shown to inhibit PERV release from producer cells, establishing ...
Mattiuzzo G, Ivol S, Takeuchi Y.
europepmc   +4 more sources