Results 21 to 30 of about 521,449 (181)

Natural Antibodies Prevent in Vivo Transmission of Porcine Islet-Derived Endogenous Retrovirus to Human Cells

Cell Transplantation, 2004
The discovery of porcine endogenous retroviruses (PERV) has raised concerns regarding the safety of porcine xenotransplantation. However, transmission of PERV had not been observed in humans exposed to porcine tissue.
Brice W. Mckane, Sabarinathan Ramachandran, Xiao-Chun Xu, Barbara J. Olack, William C. Chapman, T. Mohanakumar Ph.D.   +5 more
doaj   +2 more sources

No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation. [PDF]

Lab Anim Res, 2014
This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that underwent pig to non-human primate xenotransplantation.
Hwang S, Jung YD, Cho K, Ock SA, Oh KB, Kim HS, Yun IJ, Ahn C, Park JK, Im S.   +9 more
europepmc   +4 more sources

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing. [PDF]

Adv Sci (Weinh)
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Ma L, Yao P, Wu S, Shi Y, Qin L, Li B, Zhu J, Huang M, Zhu Y, Song Y, Pang J, Guo Z, Wu G, Wang C, Xu K, Huang R, Kuang Q, Qu L, Pan C, Xie X, Zhu Q, Huang J, Lin Q.   +22 more
europepmc   +2 more sources

Xenotransplantation Literature Update: January-June 2026. [PDF]

Xenotransplantation
ABSTRACT In the first half of 2026, xenotransplantation advanced through refinement rather than dramatic new clinical milestones. Clinical studies described graft physiology, immune infiltration, complement activation, coagulation incompatibility, and early function in living recipients, decedent models, and clinical islet xenotransplantation ...
Shirini K, Ladowski JM, Harsh N, Meier RPH.   +3 more
europepmc   +2 more sources

Porcine kidney xenotransplantation: From primate models to clinical reality. [PDF]

Animal Model Exp Med
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Guo Z, Zhang L, Deng S, Qin C.
europepmc   +2 more sources

Global Consultation for Clinical Xenotransplantation: International Xenotransplantation Association Consensus and Communiqué Update. [PDF]

Xenotransplantation
ABSTRACT Xenotransplantation has entered a phase of accelerated clinical translation, necessitating renewed international consensus on governance, ethics, safety, and regulatory oversight. In September 2025, the International Xenotransplantation Association (IXA), in partnership with The Transplantation Society (TTS) and with engagement from the World ...
Hawthorne WJ, Wolf E, Cowan PJ, Wang W, Yun IJ, Brenner P, Korbutt G, Meier RPH, Sykes M, Bühler LH, Scobie L, Garkavenko O, Kim H, Hurst DJ, Iii RNP, Rieben R, Pascual M, Scholes-Robertson N, Cozzi E, Abalovich A, Loupy A, Hara H, Bottino R, Ekser B, Mohiuddin MM, Fishman J.   +25 more
europepmc   +2 more sources

Packaging of human endogenous retrovirus sequences is undetectable in porcine endogenous retrovirus particles produced from human cells [PDF]

Virology, 2003
The chronic shortage of human donor organs and tissues for allotransplantation could be relieved if clinical xenotransplantation were to become a viable clinical therapy. Balanced against the benefits of xenotransplantation are the possible consequences of zoonotic infections, and in particular, infection by porcine endogenous retrovirus (PERV).
Suling, Kristen, Quinn, Gary, Wood, James, Patience, Clive   +3 more
openaire   +3 more sources

Long-Read Sequencing Reveals a GC Pressure during the Evolution of Porcine Endogenous Retrovirus. [PDF]

Genome Announc, 2017
Here, we present the complete genome sequence of a porcine endogenous retrovirus determined by Pacific Biosciences sequencing. A comparison of the genome of this isolate with those of other strains revealed the operation of a mechanism resulting in the ...
Szűcs A, Moldován N, Tombácz D, Csabai Z, Snyder M, Boldogkői Z.   +5 more
europepmc   +2 more sources

Absence of interaction between porcine endogenous retrovirus and porcine cytomegalovirus in pig‐to‐baboon renal xenotransplantation in vivo [PDF]

Xenotransplantation, 2018
David Sachs, Kazuhiko Yamada, Jay Fishman   +2 more
exaly   +2 more sources

Long‐term safety from transmission of porcine endogenous retrovirus after pig‐to‐non‐human primate corneal transplantation [PDF]

Xenotransplantation, 2017
Hyun Ju Lee, Mee Kum Kim, Eung Soo Hwang
exaly   +2 more sources