Long-term safety from transmission of porcine endogenous retrovirus after pig-to-non-human primate corneal transplantation. [PDF]
Xenotransplantation, 2017 Choi HJ +6 more
europepmc +2 more sources
Porcine Endogenous Retrovirus Induces CXCL10 in Human Monocytes and Monocyte-Derived Primary Cells
Intervirology, 2022 Introduction: Pigs are suitable donor species for xenotransplantation and biological materials from these animals are used for this purpose for many years.
Hussein Al-Shehabi, Norbert Bannert
doaj +1 more source
Inhibition of budding/release of porcine endogenous retrovirus [PDF]
Microbiology and Immunology, 2014 AbstractPERV is integrated into the genome of all pigs. PERV‐A and PERV‐B are polytropic and can productively infect human cell lines, whereas PERV‐C is ecotropic. Recombinant PERV‐A/C can infect human cells and exhibits high titer replication. Therefore, use of pigs for human xenotransplantation raises concerns about the risks of transfer of this ...
Masumi, Abe +4 more
openaire +2 more sources
Evidence and Consequence of Porcine Endogenous Retrovirus Recombination [PDF]
Journal of Virology, 2004 ABSTRACT The genetic nature and biological effects of recombination between porcine endogenous retroviruses (PERV) were studied. An infectious molecular clone was generated from a high-titer, human-tropic PERV isolate, PERV-A 14/220 (B. A. Oldmixon, et al. J. Virol. 76: 3045-3048, 2002; T. A.
Birke, Bartosch +5 more
openaire +2 more sources
Frontiers in Genetics, 2022 Long noncoding RNAs (lncRNAs) are increasingly being recognized as modulators of early embryonic development in mammals. However, they are seldom investigated in pigs.
Xu Yang +5 more
doaj +1 more source
Characterization of porcine endogenous retrovirus expression in neonatal and adult pig pancreatic islets [PDF]
, 2017 BACKGROUND: Pig islets represent an alternative to the current modes of treatment for patients with diabetes. However, the concerns over pathogen transmission including that of PERV limit their immediate, widespread usage in humans.
Akiyoshi +36 more
core +1 more source
Assessment of porcine endogenous retrovirus transmission across an alginate barrier used for the encapsulation of porcine islets [PDF]
, 2018 BACKGROUND: Subcutaneous implantation of a macroencapsulated patch containing human allogenic islets has been successfully used to alleviate type 1 diabetes mellitus (T1DM) in a human recipient without the need for immunosuppression.
Crossan, Claire +4 more
core +1 more source
Detection and Characterization of Porcine Endogenous Retrovirus in Porcine Plasma and Porcine Factor VIII [PDF]
Journal of Virology, 2001 ABSTRACT The pig genome contains porcine endogenous retroviruses (PERVs) capable of infecting human cells. Detection of infectious retrovirus in porcine peripheral blood mononuclear cells and endothelial cells suggested to us that pig plasma is likely to contain PERV.
D M, Takefman +4 more
openaire +2 more sources
Virological Characterization of Pigs with Erythema Multiforme
Microorganisms, 2022 Erythema multiforme in pigs is an acute, self-limiting disease characterized by red skin areas and often associated with anorexia, fever and respiratory problems. The cause of the disease remains unknown.
Sabrina Halecker +5 more
doaj +1 more source
No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation. [PDF]
Lab Anim Res, 2014 This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that underwent pig to non-human primate xenotransplantation.
Hwang S +9 more
europepmc +4 more sources