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How Active Are Porcine Endogenous Retroviruses (PERVs)? [PDF]

Viruses, 2016
Porcine endogenous retroviruses (PERVs) represent a risk factor if porcine cells, tissues, or organs were to be transplanted into human recipients to alleviate the shortage of human transplants; a procedure called xenotransplantation.
Joachim Denner
doaj   +10 more sources

Neutralizing Antibodies Against the Porcine Endogenous Retroviruses (PERVs) [PDF]

Viruses
Xenotransplantation using pig cells, tissues or organs may be associated with the transmission of porcine zoonotic or xenozoonotic microorganisms. Porcine endogenous retroviruses (PERVs) pose a special risk for xenotransplantation as these viruses can ...
Jinzhao Ban, Ludwig Krabben, Benedikt B. Kaufer, Joachim Denner   +3 more
doaj   +9 more sources

Copy Number and Prevalence of Porcine Endogenous Retroviruses (PERVs) in German Wild Boars [PDF]

Viruses, 2020
Porcine endogenous retroviruses (PERVs) are integrated in the genome of pigs and are transmitted like cellular genes from parents to the offspring. Whereas PERV-A and PERV-B are present in all pigs, PERV-C was found to be in many, but not all pigs.
Luise Krüger, Milena Stillfried, Carolin Prinz, Vanessa Schröder, Lena Katharina Neubert, Joachim Denner   +5 more
doaj   +14 more sources

Increased titers of neutralizing antibodies after immunization with both envelope proteins of the porcine endogenous retroviruses (PERVs) [PDF]

Virology Journal, 2012
Despite enormous difficulties to induce antibodies neutralizing HIV-1, especially broadly neutralizing antibodies directed against the conserved membrane proximal external region (MPER) of the transmembrane envelope protein, such antibodies can be easily
Denner Joachim, Mihica Debora, Kaulitz Danny, Schmidt Christa-Maria   +3 more
doaj   +9 more sources

Retroviral Insertion Polymorphism (RIP) of Porcine Endogenous Retroviruses (PERVs) in Pig Genomes [PDF]

Animals
Endogenous retroviruses (ERVs) are one of the superfamilies of long terminal repeat retrotransposons (LTRs) in mice and humans. Approximately 8% of the pig genome is composed of sequences derived from LTRs. While the majority of ERVs in pigs have decayed,
Zhanyu Du, Cai Chen, Yao Zheng, Xiaoyan Wang, Chengyi Song   +4 more
doaj   +4 more sources

Porcine Endogenous Retroviruses and Xenotransplantation, 2021 [PDF]

Viruses, 2021
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and some of them are able to infect human cells. Therefore, PERVs pose a risk for xenotransplantation, the transplantation of pig cells, tissues, or organ to humans in ...
Joachim Denner
doaj   +4 more sources

The Relationship between Embryonic Development and the Efficiency of Target Mutations in Porcine Endogenous Retroviruses (PERVs) Pol Genes in Porcine Embryos [PDF]

Animals, 2019
Porcine endogenous retrovirus (PERV) is a provirus found in the pig genome that may act as an infectious pathogen in humans who receive pig organ xenotransplantation.
Maki Hirata, Manita Wittayarat, Takayuki Hirano, Nhien Thi Nguyen, Quynh Anh Le, Zhao Namula, Mokhamad Fahrudin, Fuminori Tanihara, Takeshige Otoi   +8 more
doaj   +5 more sources

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology [PDF]

Health Care Sci
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Saha S, Dutta M, Bosu A.
europepmc   +2 more sources

Global Consultation for Clinical Xenotransplantation: International Xenotransplantation Association Consensus and Communiqué Update. [PDF]

Xenotransplantation
ABSTRACT Xenotransplantation has entered a phase of accelerated clinical translation, necessitating renewed international consensus on governance, ethics, safety, and regulatory oversight. In September 2025, the International Xenotransplantation Association (IXA), in partnership with The Transplantation Society (TTS) and with engagement from the World ...
Hawthorne WJ, Wolf E, Cowan PJ, Wang W, Yun IJ, Brenner P, Korbutt G, Meier RPH, Sykes M, Bühler LH, Scobie L, Garkavenko O, Kim H, Hurst DJ, Iii RNP, Rieben R, Pascual M, Scholes-Robertson N, Cozzi E, Abalovich A, Loupy A, Hara H, Bottino R, Ekser B, Mohiuddin MM, Fishman J.   +25 more
europepmc   +2 more sources

Comprehensive Protocols for Detecting Xenotransplantation-Relevant Viruses [PDF]

Methods and Protocols
Xenotransplantation using pig cells, tissues, or organs is advancing toward clinical application to address the shortage of human donor organs for treating organ failure.
Hina Jhelum, Benedikt B. Kaufer, Joachim Denner   +2 more
doaj   +2 more sources