Results 21 to 30 of about 515,911 (152)

Monitoring for PERV Following Xenotransplantation [PDF]

Transplant International
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs. PERV-A, PERV-B and PERV-C can be released as infectious virus particles and PERV-A and PERV-B can infect human cells in culture.
Joachim Denner
doaj   +2 more sources

Current Techniques of Gene Editing in Pigs for Xenotransplantation [PDF]

Transplant International
Shortage of human organs for transplantation has created a demand for alternative solutions of which xenotransplantation is amongst the most promising one in the short term. However, the immune reaction following transplantation of a pig organ is greater
Cesare Galli
doaj   +2 more sources

Xenotransplantation: Reduction of the risk of transmission of porcine endogenous retroviruses (PERV) [PDF]

, 2014
Xenotransplantation using porcine cells, tissues or organs may reduce the widening gap between demand and supply of human donor organs. However, this may be hampered by the presence of porcine endogenous retroviruses (PERVs), which belong to the γ-retroviruses family and are integrated in the porcine genome and were shown to infect human cells in vitro.
Semaan, Marwan
openaire   +4 more sources

Liver Xenotransplantation: Ethical and Societal Implications. [PDF]

Xenotransplantation
ABSTRACT The shortage of transplantable livers and high waitlist mortality rates have accelerated the clinical translation of liver xenotransplantation. Recent milestones, including extracorporeal perfusion models and gene‐edited pig‐to‐human transplants in both decedents and living patients, indicate that clinical trials may be imminent.
Hurst DJ, Bobier CA, Padilla LA, Merlocco A, Meier RPH.   +4 more
europepmc   +2 more sources

Advancing Type 1 Diabetes Treatment: 3 PM-Oriented Innovations in Islet Transplantation and Biomaterial Engineering. [PDF]

Diabetes Metab Res Rev
ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Sabet Sarvestani F, Yaghobi R, Khosravi Maharlooei M, Golshan M, Karimi MH.   +4 more
europepmc   +2 more sources

Porcine kidney xenotransplantation: From primate models to clinical reality. [PDF]

Animal Model Exp Med
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Guo Z, Zhang L, Deng S, Qin C.
europepmc   +2 more sources

Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Göttingen minipigs [PDF]

Virology Journal, 2022
Background Porcine endogenous retroviruses (PERVs) can infect human cells and pose a risk for xenotransplantation when pig cells, tissues or organs are transplanted to human recipients.
Sabrina Halecker, Ludwig Krabben, Yannick Kristiansen, Luise Krüger, Lars Möller, Dietmar Becher, Michael Laue, Benedikt Kaufer, Christian Reimer, Joachim Denner   +9 more
doaj   +6 more sources

[Endogenous porcine retroviruses and xenotransplantation]

, 2000
Vertebrate DNA contains numerous genomes closely related to retroviruses, i.e. endogenous retroviruses. While most of the retroviruses are pathogenous, endogenous retroviruses have rarely been shown as such.
Mornex, Jean-Francois
core   +7 more sources

Removal of Porcine Endogenous Retroviruses in Decellularized Liver Bioscaffolds. [PDF]

Xenotransplantation
Tissue engineering using decellularized liver scaffolds presents a promising approach in regenerative medicine, offering a potential alternative to donor organ transplantation.
van Hengel EVA, Drabek D, Roest HP, Willemse J, Reniers LJ, Stallmann H, de Jonge J, Grosveld FG, van der Laan LJW, Verstegen MMA.   +9 more
europepmc   +2 more sources

Structure of the Core Postfusion Porcine Endogenous Retrovirus Fusion Protein

mBio, 2022
Retroviral elements from endogenous retroviruses have functions in mammalian physiology. The best-known examples are the envelope proteins that function in placenta development and immune suppression.
Trevor T. Dean, Vitor Hugo B. Serrão, Jeffrey E. Lee   +2 more
doaj   +1 more source