Virological and Parasitological Characterization of Mini-LEWE Minipigs Using Improved Screening Methods and an Overview of Data on Various Minipig Breeds [PDF]
Microorganisms, 2021 Minipigs play an important role in biomedical research and have also been used as donor animals in xenotransplantation. To serve as a donor in xenotransplantation, the animals must be free of potential zoonotic viruses, bacteria and parasites.
Sabrina Halecker +5 more
doaj +6 more sources
Possible Transmission of Zoonoses in Xenotransplantation: Porcine Endogenous Retroviruses (PERVs) from an Immunological Point of View [PDF]
Acta Veterinaria Scandinavica, 2004 Possible transmission of zoonoses in xenotransplantation : porcine endogenous retroviruses (PERVs) from an immunological point of ...
Blomberg Jonas +4 more
doaj +3 more sources
Current Techniques of Gene Editing in Pigs for Xenotransplantation [PDF]
Transplant InternationalShortage of human organs for transplantation has created a demand for alternative solutions of which xenotransplantation is amongst the most promising one in the short term. However, the immune reaction following transplantation of a pig organ is greater
Cesare Galli
doaj +2 more sources
Expression of porcine endogenous retroviruses (PERV) in different organs of a pig
Virology, 2012 Porcine endogenous retroviruses (PERVs) represent a particular risk for xenotransplantation using pig cells, tissues or organs. PERVs are integrated in the genome of all pig strains and can be released as particles that infect human cells. We performed for the first time a systematic analysis of PERV expression in different organs of a miniature pig ...
Bittmann, Iris +3 more
openaire +4 more sources
Porcine Endogenous Retroviruses in Xenotransplantation—Molecular Aspects
Viruses, 2014 In the context of the shortage of organs and other tissues for use in human transplantation, xenotransplantation procedures with material taken from pigs have come under increased consideration.
Magdalena C. Kimsa +6 more
doaj +3 more sources
How to Detect Porcine Endogenous Retrovirus (PERV) Infections in Patients After Transplantation of Pig Organs. [PDF]
XenotransplantationPorcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs and can infect human cells in culture. However, no PERV infections have been reported in recipients following preclinical or clinical xenotransplantation or deliberate ...
Denner J +4 more
europepmc +3 more sources
Virus safety of xenotransplantation and porcine endogenous retroviruses (PERVs) [PDF]
, 2014 Introduction: The shortage of organs for patients is an issue that needs addressing. Xenotransplantation using pig cells or organs is the most favored option.
Anders, Maximilian
core +4 more sources
Veterinary Microbiology, 2007 Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pig breeds. Since some of them are able to infect human cells, they might represent a risk for xenotransplantation using pig cells or organs. However, the expression and biological role of PERVs in healthy pigs as well as in porcine tumours is largely unknown.
Angela Hafner-Marx +9 more
core +4 more sources
The role of human SAMHD1 in restricting porcine endogenous retroviruses (PERVs) and the innate immune response to PERV infection in human primary immune cells [PDF]
, 2021 Die Freisetzung von Porcinen Endogenen Retroviren (PERVs) aus Schweinezellen ist ein potenzieller Risikofaktor während der Xenotransplantation. PERV ist in der Lage, in humanen Zelllinien zu replizieren.
Al-shehabi, Hussein
core +4 more sources
Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5 proteins including human TRIM5 [PDF]
Journal of General Virology, 2009 The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5{
Andrew Wood +61 more
core +4 more sources