Results 31 to 40 of about 515,911 (152)
Detection of non-reference porcine endogenous retrovirus loci in the Vietnamese native pig genome
Scientific Reports, 2022 The Vietnamese native pig (VnP)—a porcine breed with a small body—has proven suitable as a biomedical animal model. Here, we demonstrate that, compared to other breeds, VnPs have fewer copies of porcine endogenous retroviruses (PERVs), which pose a risk ...
Shinya Ishihara +7 more
doaj +1 more source
Ancient origin and complex evolution of porcine endogenous retroviruses
Biosafety and Health, 2020 Porcine endogenous retroviruses (PERVs) are proviruses that have medical value in xenotransplantation. However, the evolutionary process leading to the generation of modern PERVs is not well understood.
Yicong Chen +3 more
doaj +1 more source
Virus Safety of Xenotransplantation
Viruses, 2022 The practice of xenotransplantation using pig islet cells or organs is under development to alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or organ failure.
Joachim Denner
doaj +1 more source
Possible Transmission of Zoonoses in Xenotransplantation: Porcine Endogenous Retroviruses (PERVs) from an Immunological Point of View [PDF]
Acta Veterinaria Scandinavica, 2004 Possible transmission of zoonoses in xenotransplantation : porcine endogenous retroviruses (PERVs) from an immunological point of ...
Blomberg Jonas +4 more
doaj +3 more sources
Sensitive detection systems for infectious agents in xenotransplantation*
Xenotransplantation, EarlyView., 2020 Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley +1 more source
Evidence for Microchimerism in Baboon Recipients of Pig Hearts
Viruses, 2023 Xenotransplantation, like allotransplantation, is usually associated with microchimerism, i.e., the presence of cells from the donor in the recipient.
Hina Jhelum +10 more
doaj +1 more source
Characterization of Insertional Variation of Porcine Endogenous Retroviruses in Six Different Pig Breeds [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 Pigs may need to be exploited as xenotransplantation donors due to the shortage of human organs, tissues and cells. Porcine endogenous retroviruses (PERVs) are a significant obstacle to xenotransplantation because they can infect human cells in vitro and
W. Y. Jung +7 more
doaj +1 more source
Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species [PDF]
, 2007 Background: The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host range of retroviruses.
Matouskova, M +8 more
core +1 more source
Retrovirology, 2018 Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect certain human cells and therefore pose a special risk for xenotransplantation using pig cells, tissues and organs.
Joachim Denner
doaj +1 more source
The porcine virome and xenotransplantation
Virology Journal, 2017 The composition of the porcine virome includes viruses that infect pig cells, ancient virus-derived elements including endogenous retroviruses inserted in the pig chromosomes, and bacteriophages that infect a broad array of bacteria that inhabit pigs ...
Joachim Denner
doaj +1 more source