Porcine Endogenous Retroviruses and Xenotransplantation, 2021 [PDF]
Viruses, 2021 Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and some of them are able to infect human cells. Therefore, PERVs pose a risk for xenotransplantation, the transplantation of pig cells, tissues, or organ to humans in ...
Joachim Denner
doaj +5 more sources
Microchimerism, PERV and Xenotransplantation [PDF]
Viruses, 2023 Microchimerism is the presence of cells in an individual that have originated from a genetically distinct individual. The most common form of microchimerism is fetomaternal microchimerism, i.e., cells from a fetus pass through the placenta and establish ...
Joachim Denner
doaj +5 more sources
The Relationship between Embryonic Development and the Efficiency of Target Mutations in Porcine Endogenous Retroviruses (PERVs) Pol Genes in Porcine Embryos [PDF]
Animals, 2019 Porcine endogenous retrovirus (PERV) is a provirus found in the pig genome that may act as an infectious pathogen in humans who receive pig organ xenotransplantation.
Maki Hirata +8 more
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Genome-wide inactivation of porcine endogenous retroviruses (PERVs) [PDF]
Science, 2015 Virally cleansing the pig genome Transplants from pigs could be a solution to a shortage of human organs for transplantation. Unfortunately, porcine endogenous retroviruses (PERVs) are rife in pigs and can be transmitted to humans, risking disease. L. Yang et al.
Yang, Luhan +13 more
openaire +5 more sources
Cytotoxic Effects during Knock Out of Multiple Porcine Endogenous Retrovirus (PERV) Sequences in the Pig Genome by Zinc Finger Nucleases (ZFN). [PDF]
PLoS ONE, 2015 Xenotransplantation has been proposed as a solution to the shortage of suitable human donors for transplantation and pigs are currently favoured as donor animals.
Marwan Semaan +2 more
doaj +7 more sources
High Prevalence of Recombinant Porcine Endogenous Retroviruses (PERV-A/Cs) in Minipigs: A Review on Origin and Presence [PDF]
Viruses, 2021 Minipigs play an important role in biomedical research and they have also been used as donor animals for preclinical xenotransplantations. Since zoonotic microorganisms including viruses can be transmitted when pig cells, tissues or organs are ...
Joachim Denner, Hendrik Jan Schuurman
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Co-Cultivation Assays for Detecting Infectious Human-Tropic Porcine Endogenous Retroviruses (PERVs). [PDF]
Int J Mol SciPorcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs. Since they can be released as infectious virus particles capable of infecting human cells in vitro, they pose a potential risk for xenotransplantation involving pig cells or organs.
Denner J.
europepmc +3 more sources
Comprehensive Protocols for Detecting Xenotransplantation-Relevant Viruses [PDF]
Methods and ProtocolsXenotransplantation using pig cells, tissues, or organs is advancing toward clinical application to address the shortage of human donor organs for treating organ failure.
Hina Jhelum +2 more
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Ancient origin and complex evolution of porcine endogenous retroviruses
Biosafety and Health, 2020 Porcine endogenous retroviruses (PERVs) are proviruses that have medical value in xenotransplantation. However, the evolutionary process leading to the generation of modern PERVs is not well understood.
Yicong Chen +3 more
doaj +3 more sources
Generation of neutralising antibodies against porcine endogenous retroviruses (PERVs)
Virology, 2011 Antibodies neutralising porcine endogenous retroviruses (PERVs) were induced in different animal species by immunisation with the transmembrane envelope protein p15E. These antibodies recognised epitopes, designated E1, in the fusion peptide proximal region (FPPR) of p15E, and E2 in the membrane proximal external region (MPER).
Kaulitz, Danny +5 more
openaire +4 more sources