Co-Cultivation Assays for Detecting Infectious Human-Tropic Porcine Endogenous Retroviruses (PERVs) [PDF]
International Journal of Molecular SciencesPorcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs. Since they can be released as infectious virus particles capable of infecting human cells in vitro, they pose a potential risk for xenotransplantation involving pig cells or organs.
Joachim Denner
exaly +6 more sources
High Prevalence of Recombinant Porcine Endogenous Retroviruses (PERV-A/Cs) in Minipigs: A Review on Origin and Presence [PDF]
Viruses, 2021 Minipigs play an important role in biomedical research and they have also been used as donor animals for preclinical xenotransplantations. Since zoonotic microorganisms including viruses can be transmitted when pig cells, tissues or organs are ...
Joachim Denner, Hendrik Jan Schuurman
doaj +5 more sources
Determination of the Copy Number of Porcine Endogenous Retroviruses (PERV) in Auckland Island Pigs Repeatedly Used for Clinical Xenotransplantation and Elimination of PERV-C [PDF]
Microorganisms, 2023 Auckland Island pigs represent an inbred population of feral pigs isolated on the sub-Antarctic island for over 100 years. The animals have been maintained under pathogen-free conditions in New Zealand; they are well characterized virologically and have ...
Uwe Fiebig +2 more
doaj +5 more sources
Reliable Polymerase Chain Reaction Methods for Screening for Porcine Endogenous Retroviruses-C (PERV-C) in Pigs [PDF]
VirusesPorcine endogenous retrovirus C (PERV-C) is a gammaretrovirus present in the genome of many, but not all, pigs. It is an ecotropic virus, able to infect only pig cells.
Hina Jhelum +4 more
doaj +4 more sources
Virus safety of xenotransplantation and porcine endogenous retroviruses (PERVs) [PDF]
, 2014 Introduction: The shortage of organs for patients is an issue that needs addressing. Xenotransplantation using pig cells or organs is the most favored option. However, pigs contain porcine endogenous retroviruses (PERV) in their genome which infect human cells. Like all retroviruses PERVs have immunosuppressive properties and may induce tumors.
Anders, Maximilian
openaire +4 more sources
Genomic Validation of PERV-C-Free Pigs to Support Xenotransplantation. [PDF]
XenotransplantationABSTRACT Porcine endogenous retroviruses (PERVs) are present in the germ lines of domesticated pigs (Sus scrofa) and related suids. There are three types of PERVs, PERV‐A, ‐B, and ‐C, which differ in their host range. PERV‐A and ‐B can infect human and porcine cells, while PERV‐C only infects porcine cells. PERV‐A and ‐B are found in the genomes of all
Benjamin NR +6 more
europepmc +2 more sources
Porcine Endogenous Retroviruses in Xenotransplantation—Molecular Aspects
Viruses, 2014 In the context of the shortage of organs and other tissues for use in human transplantation, xenotransplantation procedures with material taken from pigs have come under increased consideration.
Magdalena C. Kimsa +6 more
doaj +2 more sources
Microchimerism, PERV and Xenotransplantation [PDF]
Viruses, 2023 Microchimerism is the presence of cells in an individual that have originated from a genetically distinct individual. The most common form of microchimerism is fetomaternal microchimerism, i.e., cells from a fetus pass through the placenta and establish ...
Joachim Denner
doaj +2 more sources
Xenoperfusion-The Transformative Role of Machine Perfusion in Xenotransplantation. [PDF]
XenotransplantationABSTRACT Recent advances in xenotransplantation have gained substantial public and clinical attention as genetically modified porcine organs are now being transplanted into living human recipients. While only case reports have been published to date, the first clinical trials for kidney xenotransplantation are now ongoing.
Huwyler F +3 more
europepmc +2 more sources
Expression of porcine endogenous retroviruses (PERV) in different organs of a pig [PDF]
Virology, 2012 Porcine endogenous retroviruses (PERVs) represent a particular risk for xenotransplantation using pig cells, tissues or organs. PERVs are integrated in the genome of all pig strains and can be released as particles that infect human cells. We performed for the first time a systematic analysis of PERV expression in different organs of a miniature pig ...
Bittmann, Iris +3 more
openaire +3 more sources