Evidence for Microchimerism in Baboon Recipients of Pig Hearts
Viruses, 2023 Xenotransplantation, like allotransplantation, is usually associated with microchimerism, i.e., the presence of cells from the donor in the recipient.
Hina Jhelum +10 more
doaj +1 more source
Characterization of Insertional Variation of Porcine Endogenous Retroviruses in Six Different Pig Breeds [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 Pigs may need to be exploited as xenotransplantation donors due to the shortage of human organs, tissues and cells. Porcine endogenous retroviruses (PERVs) are a significant obstacle to xenotransplantation because they can infect human cells in vitro and
W. Y. Jung +7 more
doaj +1 more source
Organ Transplantation: Current Status, Challenges, and Future Prospects. [PDF]
MedComm (2020)Organ transplantation success relies on precise modulation of the alloimmune response across distinct temporal phases of rejection. Hyperacute rejection results from preformed antibodies activating complement and causing thrombosis, while acute rejection involves T cell‐ and antibody‐mediated mechanisms that drive endothelial activation and ...
Li X, Ding R, Cai J.
europepmc +2 more sources
When should precaution prevail? : interests in (public) health, the risk of harm and xenotransplantation. [PDF]
, 2010 Xenotransplantation is an example of a developing biotechnology which highlights three differing interests in the health of the public; a specific interest in enhancing the health of individuals who require a particular procedure or treatment, a wider ...
Fovargue, Sara, Ost, Suzanne
core +1 more source
Highly Variable Genomic Landscape of Endogenous Retroviruses in the C57BL/6J Inbred Strain, Depending on Individual Mouse, Gender, Organ Type, and Organ Location. [PDF]
, 2017 Transposable repetitive elements, named the "TREome," represent ~40% of the mouse genome. We postulate that the germ line genome undergoes temporal and spatial diversification into somatic genomes in conjunction with the TREome activity.
Cho, Kiho +3 more
core +2 more sources
Basic sciences in development: What changes will we see in transplantation in the next five years? [PDF]
, 2016 Copyrigh
Baan, C.C. (Carla)
core +7 more sources
Retrovirology, 2018 Porcine endogenous retroviruses (PERVs) are present in the genome of all pigs, they infect certain human cells and therefore pose a special risk for xenotransplantation using pig cells, tissues and organs.
Joachim Denner
doaj +1 more source
Characterization of porcine endogenous retrovirus expression in neonatal and adult pig pancreatic islets [PDF]
, 2017 BACKGROUND: Pig islets represent an alternative to the current modes of treatment for patients with diabetes. However, the concerns over pathogen transmission including that of PERV limit their immediate, widespread usage in humans.
Akiyoshi +36 more
core +1 more source
The porcine virome and xenotransplantation
Virology Journal, 2017 The composition of the porcine virome includes viruses that infect pig cells, ancient virus-derived elements including endogenous retroviruses inserted in the pig chromosomes, and bacteriophages that infect a broad array of bacteria that inhabit pigs ...
Joachim Denner
doaj +1 more source
Cellular xenotransplantation of animal cells into people: benefits and risk [PDF]
, 2018 The main benefit of xenotransplantation is its potential to overcome the worldwide organ shortage experienced in allotransplantation. Allogeneic transplantation is the only successful therapy for several life-threatening diseases, with cell, tissue or ...
Cozzi, Emanuele +4 more
core +1 more source