Results 41 to 50 of about 515,911 (152)

A paradigm for virus-host coevolution: sequential counter-adaptations between endogenous and exogenous retroviruses [PDF]

, 2007
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections of the host germline transmitted 1vertically from generation to generation. It is hypothesized that some ERVs are used by the host as 1restriction factors to block the infection
Pereira, Filipe, LEYMASTER K, Pereira, P., Golder, Matthew, James C Demartini, Leymaster, Kreg, Mura, M., Mura, Manuela, Golder, M., Biek, R., Pereira Filipe, Golder, Matthew C., Arnaud, Frederick, Bernardo Chessa, Yu Li, CAPORALE M, Zhang, Y-P., Matthew Golder, Thomas E Spencer, Caporale Marco, Palmarini, Massimo, Alberti Alberto, Yu, Li, Arnaud Frederick, Biek Roman, Frederick Arnaud, Alberti, A., Arnaud, F., Spencer Thomas E, Ya-Ping Zhang, SPENCER T. E, Caporale, M., Li Yu, Palmarini, M., Varela, M., Kreg Leymaster, PEREIRA F, DeMartini, J.C., Zhang, Ya-ping, Mariana Varela, Spencer, T.E., ZHANG Y. P, Chessa, B., Chessa Bernardo, Mura Manuela, Alberto Alberti, Roman Biek, Varela Mariana, Leymaster Kreg, Spencer, Thomas,, ARNAUD F, BIEK R, Varela, Mariana, YU L, Golder Matthew, PALMARINI M., Chessa, Bernardo, Palmarini Massimo, Spencer, Thomas E., Manuela Mura, Biek, Roman, Spencer, Thomas E, DeMartini, James C., Leymaster, K., Filipe Pereira, Marco Caporale, Massimo Palmarini, Demartini, James, Demartini, James C, GOLDER M, DeMartini James C, Malim, Michael H, Yu, L., VARELA M, Caporale, Marco, Zhang Ya-ping, MURA M, DEMARTINI J. C, Alberti, Alberto   +78 more
core   +1 more source

Can Antiretroviral Drugs Be Used to Treat Porcine Endogenous Retrovirus (PERV) Infection after Xenotransplantation?

Viruses, 2017
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs; they are released as infectious particles, and under certain conditions they can infect human cells. Therefore, they represent a risk when pigs are used as sources of cells,
Joachim Denner
doaj   +1 more source

Porcine Endogenous Retroviruses Inhibit Human Immune Cell Function: Risk for Xenotransplantation? [PDF]

, 2000
Transgenic pigs are currently the most favored potential source of organs for xenotransplantation. Like all mammalian species they all harbor endogenous retroviruses in their genome. These porcine endogenous retroviruses (PERVs) are produced from several
Tacke, Stefan J., Kurth, Reinhard, Denner, Joachim   +2 more
core   +1 more source

Cytotoxic Effects during Knock Out of Multiple Porcine Endogenous Retrovirus (PERV) Sequences in the Pig Genome by Zinc Finger Nucleases (ZFN). [PDF]

PLoS ONE, 2015
Xenotransplantation has been proposed as a solution to the shortage of suitable human donors for transplantation and pigs are currently favoured as donor animals.
Marwan Semaan, Daniel Ivanusic, Joachim Denner   +2 more
doaj   +1 more source

Transspecies Transmission of Gammaretroviruses and the Origin of the Gibbon Ape Leukaemia Virus (GaLV) and the Koala Retrovirus (KoRV)

Viruses, 2016
Transspecies transmission of retroviruses is a frequent event, and the human immunodeficiency virus-1 (HIV-1) is a well-known example. The gibbon ape leukaemia virus (GaLV) and koala retrovirus (KoRV), two gammaretroviruses, are also the result of a ...
Joachim Denner
doaj   +1 more source

Virological and Parasitological Characterization of Mini-LEWE Minipigs Using Improved Screening Methods and an Overview of Data on Various Minipig Breeds

Microorganisms, 2021
Minipigs play an important role in biomedical research and have also been used as donor animals in xenotransplantation. To serve as a donor in xenotransplantation, the animals must be free of potential zoonotic viruses, bacteria and parasites.
Sabrina Halecker, Julia Metzger, Christina Strube, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

Construction of a transposase accessible chromatin landscape reveals chromatin state of repeat elements and potential causal variant for complex traits in pigs

Journal of Animal Science and Biotechnology, 2022
Background A comprehensive landscape of chromatin states for multiple mammalian tissues is essential for elucidating the molecular mechanism underlying regulatory variants on complex traits.
Tao Jiang, Ziqi Ling, Zhimin Zhou, Xiaoyun Chen, Liqing Chen, Sha Liu, Yingchun Sun, Jiawen Yang, Bin Yang, Jianzhen Huang, Lusheng Huang   +10 more
doaj   +1 more source

Porcine Endogenous Retrovirus Induces CXCL10 in Human Monocytes and Monocyte-Derived Primary Cells

Intervirology, 2022
Introduction: Pigs are suitable donor species for xenotransplantation and biological materials from these animals are used for this purpose for many years.
Hussein Al-Shehabi, Norbert Bannert
doaj   +1 more source

Detection of a gammaretrovirus, XMRV, in the human population: Open questions and implications for xenotransplantation

Retrovirology, 2010
XMRV (xenotropic murine leukaemia virus-related virus) is a gammaretrovirus that has been detected in human patients with prostate carcinoma, chronic fatigue syndrome (CFS) and also in a small percentage of clinically healthy individuals.
Denner Joachim
doaj   +1 more source

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

, 2017
The shortage of organs for transplantation is a major barrier to the treatment of organ failure. While porcine organs are considered promising, their use has been checked by concerns about transmission of porcine endogenous retroviruses (PERVs) to humans.
Niu, D., Lesha, E., Xu, W., Guell, Marc, Aach, John, Poci, Jurgen, Church, George, George, H., Fishman, Jay, Shrock, Ellen, Grishin, Dennis, Wilkinson, R. A., Cortazio, R., Yang, Luhan   +13 more
core   +1 more source