Results 61 to 70 of about 515,911 (152)

Ethical Considerations in Islet Xenotransplantation

Xenotransplantation, Volume 33, Issue 4, July/August 2026.
ABSTRACT For the management of type 1 diabetes, islet xenotransplantation has emerged as a potential alternative to lifelong insulin therapy or islet allotransplantation. However, this progress raises significant ethical questions that warrant further exploration.
Daniel J. Hurst, Alexa Tarzy, Christopher A. Bobier, Luz A. Padilla, Johannes Kögel, Anthony Merlocco, Raphael P. H. Meier   +6 more
wiley   +1 more source

Infection Barriers to Successful Xenotransplantation Focusing on Porcine Endogenous Retroviruses [PDF]

, 2012
Xenotransplantation may be a solution to overcome the shortage of organs for the treatment of patients with organ failure, but it may be associated with the transmission of porcine microorganisms and the development of xenozoonoses.
Tönjes, Ralf R., Denner, Joachim
core   +1 more source

Determination of the copy numbers of type A porcine endogenous retroviruses in domestic pigs and wild boars

Вавиловский журнал генетики и селекции, 2017
Modern transplantology is in need of transplants. To solve this problem, the use of animal organs and tissues for grafting to humans (xenografts) has been proposed. However, the progress in this direction is hampered by the risk of zoogenous infection of 
R. B. Aitnazarov, N. S. Yudin, R. S. Kiril’chuk, N. N. Kochnev, S. P. Knyazev, M. I. Voevoda   +5 more
doaj   +1 more source

An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy

EBioMedicine, 2020
Background: Gene therapy has held promises for treating specific genetic diseases. However, the key to clinical application depends on effective gene delivery.
Gang Niu, Zhuang Jin, Chong Zhang, Dan He, Xueqin Gao, Chenming Zou, Wei Zhang, Jiahui Ding, Bhudev C. Das, Konstantin Severinov, Inga Isabel Hitzeroth, Priya Ranjan Debata, Xin Ma, Xun Tian, Qinglei Gao, Jun Wu, Zeshan You, Rui Tian, Zifeng Cui, Weiwen Fan, Weiling Xie, Zhaoyue Huang, Chen Cao, Wei Xu, Hongxian Xie, Hongyan Xu, Xiongzhi Tang, Yan Wang, Zhiying Yu, Hui Han, Songwei Tan, Shuqin Chen, Zheng Hu   +32 more
doaj   +1 more source

Inhibition of porcine endogenous retroviruses by RNA interference: increasing the safety of xenotransplantation [PDF]

, 2004
Transplantation of porcine xenografts into human recipients is a realistic option to overcome the growing worldwide shortage of suitable allogeneic organs.
Karlas, Alexander, Kurth, Reinhard, Denner, Joachim   +2 more
core   +1 more source

Xenotransplantation Literature Update: January–June 2026

Xenotransplantation, Volume 33, Issue 4, July/August 2026.
ABSTRACT In the first half of 2026, xenotransplantation advanced through refinement rather than dramatic new clinical milestones. Clinical studies described graft physiology, immune infiltration, complement activation, coagulation incompatibility, and early function in living recipients, decedent models, and clinical islet xenotransplantation ...
Kasra Shirini, Joseph M. Ladowski, Niket Harsh, Raphael P. H. Meier   +3 more
wiley   +1 more source

Bioartificial Livers Developed From Gene‐Edited Pig Hepatocyte Organoids Improve Amino Acid and Lipid Profiles in the Plasma of Patients With Liver Failure

MedComm, Volume 7, Issue 6, June 2026.
A bioartificial liver (BAL) integrating GGTA1‐knockout porcine hepatocytes and R‐spondin1‐overexpressing endothelial organoids was tested using plasma from patients with acute‐on‐chronic liver failure (ACLF). The BAL system actively modulates amino acid and lipid metabolism, enhances detoxification, partially restores overall metabolic balance, and ...
Yuting He, Yang Deng, Xinglong Zhu, Mengyu Gao, Qin Liu, Wanliu Peng, Yanyan Zhou, Lang Bai, Ji Bao   +8 more
wiley   +1 more source

Microbiological safety of a novel bio-artificial liver support system based on porcine hepatocytes: a experimental study

European Journal of Medical Research, 2012
Background Our institute has developed a novel bio-artificial liver (BAL) support system, based on a multi-layer radial-flow bioreactor carrying porcine hepatocytes and mesenchymal stem cells.
Han Bing, Shi Xiao-lei, Zhang Yue, Chu Xue-hui, Gu Jin-yang, Xiao Jiang-qiang, Ren Hao-zhen, Tan Jia-jun, Gu Zhong-ze, Ding Yi-tao   +9 more
doaj   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Early Experimental Report of the First 8‐Gene‐Edited Pig‐to‐Rhesus Macaque Cardiac Xenotransplantation in China

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT Objectives This study aimed to investigate the functional recovery of an 8‐gene‐edited pig heart after orthotopic xenotransplantation, the characteristics of the recipient's immune responses, and the efficacy of postoperative complication management to provide comprehensive experimental evidence for the clinical translation of xenogeneic ...
Xianzhi Wang, Xijie Wu, Ziqiang Dai, Licheng Yan, Jie Yan, Dongsheng He, Shangxuan Li, Zhipeng Ren, Gen Zhang, Guanzheng Cui, Xin Li, Xianhua Li, Yulong Guan, Guangyu Pan, Ik Jin Yun, Wensheng Zhou, Dengke Pan, Dianyuan Li   +17 more
wiley   +1 more source