Results 61 to 70 of about 882 (164)
Potential for clinical pancreatic islet xenotransplantation [PDF]
, 2014 Diabetes mellitus is increasing worldwide. Type 1 diabetes can be treated successfully by islet allotransplantation, the results of which are steadily improving.
Bottino, R +6 more
core +1 more source
Retrovirology, 2010 XMRV (xenotropic murine leukaemia virus-related virus) is a gammaretrovirus that has been detected in human patients with prostate carcinoma, chronic fatigue syndrome (CFS) and also in a small percentage of clinically healthy individuals.
Denner Joachim
doaj +1 more source
Porcine Endogenous Retrovirus Induces CXCL10 in Human Monocytes and Monocyte-Derived Primary Cells
Intervirology, 2022 Introduction: Pigs are suitable donor species for xenotransplantation and biological materials from these animals are used for this purpose for many years.
Hussein Al-Shehabi, Norbert Bannert
doaj +1 more source
The role of human SAMHD1 in restricting porcine endogenous retroviruses (PERVs) and the innate immune response to PERV infection in human primary immune cells [PDF]
, 2020 The release of porcine endogenous retrovirus (PERV) particles from pig cells is a potential risk factor during xenotransplantation by way of productively infecting the human transplant recipient.
Al-shehabi, Hussein Ali Nasser
core +1 more source
Intervirology, 2005 <i>Objective:</i> Porcine endogenous retroviruses (PERVs) pose a risk for xenotransplantations using pig materials as they are present in the genome of all pigs and are able to infect human cells in vitro. Until recently, transmission of PERVs in vivo was only described in severe combined immunodeficient (SCID) and nude mice inoculated with
Markus, Irgang +7 more
openaire +2 more sources
Characterisation of a human cell-adapted porcine endogenous retrovirus PERV-A/C. [PDF]
, 2010 Background: Porcine endogenous retroviruses (PERVs) pose a potential risk for xenotransplantation using pig cells, tissues or organs. A special threat comes from viruses generated by recombination between human-tropic PERV-A and ecotropic PERV-C ...
Denner, Joachim +6 more
core +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Background Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease marked by the destruction of pancreatic β‐cells, resulting in lifelong dependence on exogenous insulin. Despite advances in insulin delivery and glucose monitoring technologies, patients remain at risk for acute and long‐term complications, underscoring the need for ...
Tzu‐Min Lin +5 more
wiley +1 more source
Xenoperfusion—The Transformative Role of Machine Perfusion in Xenotransplantation
Xenotransplantation, Volume 33, Issue 3, May/June 2026.ABSTRACT Recent advances in xenotransplantation have gained substantial public and clinical attention as genetically modified porcine organs are now being transplanted into living human recipients. While only case reports have been published to date, the first clinical trials for kidney xenotransplantation are now ongoing.
Florian Huwyler +3 more
wiley +1 more source
The Japanese Macaque as a Diabetes Recipient Animal Model for Porcine Islet Xenotransplantation
MedComm, Volume 7, Issue 4, April 2026.Porcine islet xenotransplantation is effective for severe diabetes; however, preclinical studies are essential. In this study, we evaluated the suitability of the Japanese macaque as a recipient model for islet xenotransplantation, including identifying the preferred method to induce diabetes.
Naoaki Sakata +4 more
wiley +1 more source
Xenotransplantation: Reduction of the risk of transmission of porcine endogenous retroviruses (PERV) [PDF]
, 2014 Die Xenotransplantation mit porzinen Zellen, Gewebe oder Organe könnte die immer größer werdende Lücke zwischen Nachfrage und Angebot der menschlichen Spenderorgane reduzieren. Dies kann jedoch durch die Anwesenheit von porzinen endogenen Retroviren (PERVs) erschwert werden.
openaire +2 more sources