Results 71 to 80 of about 515,911 (152)

The Japanese Macaque as a Diabetes Recipient Animal Model for Porcine Islet Xenotransplantation

MedComm, Volume 7, Issue 4, April 2026.
Porcine islet xenotransplantation is effective for severe diabetes; however, preclinical studies are essential. In this study, we evaluated the suitability of the Japanese macaque as a recipient model for islet xenotransplantation, including identifying the preferred method to induce diabetes.
Naoaki Sakata, Gumpei Yoshimatsu, Ryo Kawakami, Seiichi Tanaka, Shohta Kodama   +4 more
wiley   +1 more source

Identification of a novel type C porcine endogenous retrovirus: evidence that copy number of endogenous retroviruses increases during host inbreeding

, 2001
Different classes of porcine endogenous retroviruses (PERVs), which have the potential to infect humans during xenotransplantation, have been isolated from the pig genome.
Mang, R., Maas, J., Goudsmit, J., Chen, X., van der Kuyl, A. C.   +4 more
core   +1 more source

Evolution of endogenous retroviruses in the Suidae: evidence for different viral subpopulations in African and Eurasian host species

BMC Evolutionary Biology, 2011
Background Porcine endogenous retroviruses (PERVs) represent remnants of an exogenous form that have become integrated in the domestic pig (Sus scrofa) genome. Although they are usually inactive, the capacity of γ1 ERVs to infect human cells in vitro has
Charleston Michael, Gongora Jaime, Nascimento Fabrícia F, Tristem Michael, Lowden Stewart, Moran Chris   +5 more
doaj   +1 more source

Xenotransplantation Literature Update: July–December 2025

Xenotransplantation, Volume 33, Issue 2, March/April 2026.
ABSTRACT The second half of 2025 marked a significant transition for xenotransplantation, shifting further from experimental feasibility to early clinical translation. Prolonged physiologic support from genetically engineered porcine kidneys and livers in human recipients provided unprecedented insight into organ compatibility, rejection dynamics, and ...
Kasra Shirini, Joseph M. Ladowski, Niket Harsh, Raphael P. H. Meier   +3 more
wiley   +1 more source

Organ Transplantation: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
Organ transplantation success relies on precise modulation of the alloimmune response across distinct temporal phases of rejection. Hyperacute rejection results from preformed antibodies activating complement and causing thrombosis, while acute rejection involves T cell‐ and antibody‐mediated mechanisms that drive endothelial activation and ...
Xinqiang Li, Ruidong Ding, Jinzhen Cai
wiley   +1 more source

Productive Infection of Human Primary Cells and Cell Lines with Porcine Endogenous Retroviruses [PDF]

, 2001
Porcine endogenous retroviruses (PERVs) infect human cells in vitro and therefore represent a risk for xenotransplantation. However, first clinical transplantations of pig cells into humans or ex vivo perfusions did not result in transmission of PERVs ...
Denner, J., Specke, V., Rubant, S.
core   +1 more source

A Structural Characterization of the Core Post-fusion Porcine Endogenous Retrovirus Fusion Protein [PDF]

, 2022
Porcine endogenous retroviruses (PERVs) are an understudied endogenous retrovirus that can infect human cells. PERV envelope glycoproteins have also been proposed as swine syncytin candidates.
Dean, Trevor Thomas
core   +1 more source

Additional file 1 of Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Göttingen minipigs

, 2022
Additional file 1. Figure S1: Sequence of a part of the envelope protein of the PERV isolated from GöMP number 8 in comparison with sequences of a PERV-A (Accession-Number AJ293656.1), a PERV-C (Accession-Number KY352351), and PERV-F [11].
Halecker, Sabrina, Krabben, Ludwig, Kristiansen, Yannick, Krüger, Luise, Möller, Lars, Becher, Dietmar, Laue, Michael, Kaufer, Benedikt, Reimer, Christian, Denner, Joachim   +9 more
openaire   +1 more source

Neutralizing antibodies against conserved domains of p15E of porcine endogenous retroviruses: basis for a vaccine for xenotransplantation? [PDF]

, 2003
Porcine xenotransplants may offer a potential solution to the problem posed by the limited supply of allotransplants. However, xenotransplantation may be associated with the risk of transmission of microorganisms, in particular of porcine endogenous ...
Kurth, Reinhard, Fiebig, Uwe, Stephan, Oliver, Denner, Joachim   +3 more
core   +1 more source

Screening for Viruses in Indigenous Greek Black Pigs

Microorganisms
The successful advancement of xenotransplantation has led to the development of highly sensitive detection systems for the screening of potentially zoonotic viruses in donor pigs and preventing their transmission to the recipient.
Hina Jhelum, Vasileios Papatsiros, Georgios Papakonstantinou, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source