Results 71 to 80 of about 882 (164)

Xenotransplantation Literature Update: July–December 2025

Xenotransplantation, Volume 33, Issue 2, March/April 2026.
ABSTRACT The second half of 2025 marked a significant transition for xenotransplantation, shifting further from experimental feasibility to early clinical translation. Prolonged physiologic support from genetically engineered porcine kidneys and livers in human recipients provided unprecedented insight into organ compatibility, rejection dynamics, and ...
Kasra Shirini, Joseph M. Ladowski, Niket Harsh, Raphael P. H. Meier   +3 more
wiley   +1 more source

A Comprehensive Strategy for Screening for Xenotransplantation-Relevant Viruses in a Second Isolated Population of Göttingen Minipigs

Viruses, 2019
Xenotransplantation using pig tissues and organs is under development in order to alleviate the increasing shortage of human transplants. Since xenotransplantation may be associated with the transmission of porcine microorganisms to the human recipient ...
Luise Krüger, Yannick Kristiansen, Emelie Reuber, Lars Möller, Michael Laue, Christian Reimer, Joachim Denner   +6 more
doaj   +1 more source

Determination of the copy numbers of type A porcine endogenous retroviruses in domestic pigs and wild boars

Вавиловский журнал генетики и селекции, 2017
Modern transplantology is in need of transplants. To solve this problem, the use of animal organs and tissues for grafting to humans (xenografts) has been proposed. However, the progress in this direction is hampered by the risk of zoogenous infection of 
R. B. Aitnazarov, N. S. Yudin, R. S. Kiril’chuk, N. N. Kochnev, S. P. Knyazev, M. I. Voevoda   +5 more
doaj   +1 more source

An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy

EBioMedicine, 2020
Background: Gene therapy has held promises for treating specific genetic diseases. However, the key to clinical application depends on effective gene delivery.
Gang Niu, Zhuang Jin, Chong Zhang, Dan He, Xueqin Gao, Chenming Zou, Wei Zhang, Jiahui Ding, Bhudev C. Das, Konstantin Severinov, Inga Isabel Hitzeroth, Priya Ranjan Debata, Xin Ma, Xun Tian, Qinglei Gao, Jun Wu, Zeshan You, Rui Tian, Zifeng Cui, Weiwen Fan, Weiling Xie, Zhaoyue Huang, Chen Cao, Wei Xu, Hongxian Xie, Hongyan Xu, Xiongzhi Tang, Yan Wang, Zhiying Yu, Hui Han, Songwei Tan, Shuqin Chen, Zheng Hu   +32 more
doaj   +1 more source

Polymorphic post-transplant lymphoproliferative disorder in a gilt [PDF]

, 2019
N.A.
Avallone G., Bacci M.L., Barone F., Corradetti V., Dondi F., La Manna G., Pellegrino V., Sarli G., Spadari A., Tura G., Ventrella D., Villa R.   +11 more
core   +1 more source

OMICS Analyses in Xenotransplantation: Initial Findings, Key Precautions, and Virus Infections

Xenotransplantation, Volume 32, Issue 6, November/December 2025.
ABSTRACT OMICS analyses have the potential to greatly enhance our understanding of rejection and other processes in xenotransplantation. These approaches may therefore contribute to extending the survival time of xenotransplants. Initial OMICS studies in brain‐dead patients following transplantation of pig kidneys or hearts revealed increased ...
Joachim Denner
wiley   +1 more source

Microbiological safety of a novel bio-artificial liver support system based on porcine hepatocytes: a experimental study

European Journal of Medical Research, 2012
Background Our institute has developed a novel bio-artificial liver (BAL) support system, based on a multi-layer radial-flow bioreactor carrying porcine hepatocytes and mesenchymal stem cells.
Han Bing, Shi Xiao-lei, Zhang Yue, Chu Xue-hui, Gu Jin-yang, Xiao Jiang-qiang, Ren Hao-zhen, Tan Jia-jun, Gu Zhong-ze, Ding Yi-tao   +9 more
doaj   +1 more source

Modulation of Porcine Endogenous Retroviruses (PERVs) expression in vitro by shRNA in the presence of cyclosporine A and dexamethasone

Annals of Transplantation, 2012
Despite the fact that the risk of Porcine Endogenous Retroviruses (PERV) infection and propagation in human recipients is extremely low, such an event cannot be completely ruled out, especially in immunosuppressed patients. Therefore, the aim of this study was to analyze the expression of PERVs in vitro in the presence of immunosuppression agents ...
Daniel, Sypniewski, Ilona, Bednarek, Daria, Matczyńska, Sabina, Gałka, Tomasz, Loch, Dagna, Sołtysik, Grzegorz, Machnik, Ewa, Nowak   +7 more
openaire   +3 more sources

Production and Functional Verification of 8‐Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)‐Edited Donor Pigs for Xenotransplantation

Cell Proliferation, Volume 58, Issue 9, September 2025.
Schematic representation of generation of 8‐gene‐edited cloned pigs and their verification by pig to non‐human primate kidney xenotransplantation. ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear.
Jiaoxiang Wang, Kaixiang Xu, Tao Liu, Heng Zhao, Muhammad Ameen Jamal, Gen Chen, Xiaoying Huo, Chang Yang, Deling Jiao, Taiyun Wei, Hanfei Huang, Hongfang Zhao, Jianxiong Guo, Fengchong Wang, Xiong Zhang, Kai Liu, Siming Qu, Gang Wang, Hui Guo, Gang Chen, Hong‐Ye Zhao, Zhong Zeng, Kefeng Dou, Hong‐Jiang Wei   +23 more
wiley   +1 more source

Biocompatibility of Genetically‐Engineered Pig Cornea in Corneal Xenotransplantation: Preliminary In Vitro Study

Xenotransplantation, Volume 32, Issue 5, September/October 2025.
ABSTRACT Introduction We aimed to evaluate biophysical compatibility of corneal endothelial cells in genetically‐engineered (GE) pigs to identify the best candidate for in vivo nonhuman primate (NHP) study and to collect baseline data for future clinical trials from a biological function perspective.
Seung Hyeun Lee, Chung Young Kim, Jin Suk Ryu, Dong Hee Choi, Chang Ho Yoon, Chung‐Gyu Park, Kimyung Choi, Hyunil Kim, Mee Kum Kim   +8 more
wiley   +1 more source