Xenotransplantation, Volume 32, Issue 2, March/April 2025.ABSTRACT Recent landmark clinical translation of xenotransplantation depended upon multiple innovations by the xenotransplant community, including the introduction of a variety of source pig genetic modifications, technical innovations, and novel immunosuppressive strategies, as well as the development of ethical and regulatory frameworks to support ...
Wayne J. Hawthorne +10 more
wiley +1 more source
, 2022 Additional file 1. Figure S1: Sequence of a part of the envelope protein of the PERV isolated from GöMP number 8 in comparison with sequences of a PERV-A (Accession-Number AJ293656.1), a PERV-C (Accession-Number KY352351), and PERV-F [11].
Halecker, Sabrina +9 more
openaire +1 more source
An Evolutionarily Young Polar Bear (Ursus maritimus) Endogenous Retrovirus Identified from Next Generation Sequence Data [PDF]
, 2018 Transcriptome analysis of polar bear (Ursus maritimus) tissues identified sequences with similarity to Porcine Endogenous Retroviruses (PERV). Based on these sequences, four proviral copies and 15 solo long terminal repeats (LTRs) of a newly described ...
Alquezar-Planas, David E. +3 more
core +1 more source
The Relationship between Embryonic Development and the Efficiency of Target Mutations in Porcine Endogenous Retroviruses (PERVs) Pol Genes in Porcine Embryos [PDF]
, 2020 Porcine endogenous retrovirus (PERV) is a provirus found in the pig genome that may act as an infectious pathogen in humans who receive pig organ xenotransplantation.
Fahrudin, Mokhamad +8 more
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Distribution of porcine endogenous retroviruses (PERVs) DNA in organs of a domestic pig.
Annals of transplantation, 2005 Domestic pig may serve as the most appropriate organ source for human xenotransplantation in the future. However, there is a serious threat of xenogeneic pathogens transmission, especially porcine endogenous retroviruses (PERVs) which are present in genomes of all pigs. The aim of this study was to monitor the prevalence and distribution of PERV DNA in
Daniel, Sypniewski +6 more
openaire +1 more source
Is it currently possible to evaluate the risk posed by PERVs for clinical xenotransplantation? [PDF]
, 2018 Denner, Joachim +2 more
core +1 more source
Viral pathogens: what are they and do they matter? [PDF]
, 2018 Andrea Perota +30 more
core +1 more source
Die Xenotransplantation (XTx) vom Schwein auf den Menschen hat das Potenzial, den Mangel an menschlichen Allotransplantaten zu beheben. Trotz der erheblichen Fortschritte der letzten Jahre kann das zoonotische Risiko durch die potenzielle Übertragung porziner endogener Retroviren (PERVs) nicht ausgeschlossen werden. Im Gegensatz zu den meisten porzinen
openaire +2 more sources
Characterising and Mapping Porcine Endogenous Retroviruses (PERVs) [PDF]
, 2001 The initial focus of this PhD project was on comparative gene mapping. Comparative gene mapping is facilitated by consensus PCR primers which amplify homologous gene fragments in many species.
Lee, Jun Heon
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The Relationship between Embryonic Development and the Efficiency of Target Mutations in Porcine Endogenous Retroviruses (PERVs) Pol Genes in Porcine Embryos [PDF]
, 2019 Porcine endogenous retrovirus (PERV) is a provirus found in the pig genome that may act as an infectious pathogen in humans who receive pig organ xenotransplantation.
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