Results 81 to 90 of about 882 (164)

Distribution and expression of porcine endogenous retroviruses in multi-transgenic pigs generated for xenotransplantation [PDF]

, 2009
Background: Multi-transgenic pigs produced for use in xenotransplantation have to be screened for the presence and expression of porcine endogenous retroviruses (PERV) to select animals with low PERV load.
Denner, Joachim, Dieckhoff, Britta, Jobst, Danny, Kessler, Barbara, Kues, Wilfried A., Kurth, Reinhard, Niemann, Heiner, Petersen, Björn, Pfeifer, Alexander, Wolf, Eckhard   +9 more
core   +1 more source

Clinical Xenotransplantation of Gene‐Edited Pig Organs: A Review of Experiments in Living Humans Since 2022

Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.
Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley   +1 more source

Evolution of endogenous retroviruses in the Suidae: evidence for different viral subpopulations in African and Eurasian host species

BMC Evolutionary Biology, 2011
Background Porcine endogenous retroviruses (PERVs) represent remnants of an exogenous form that have become integrated in the domestic pig (Sus scrofa) genome. Although they are usually inactive, the capacity of γ1 ERVs to infect human cells in vitro has
Charleston Michael, Gongora Jaime, Nascimento Fabrícia F, Tristem Michael, Lowden Stewart, Moran Chris   +5 more
doaj   +1 more source

Virological aspects of non-human primates or swine-to human xenotransplantation [PDF]

, 2018
There are a number of human diseases, which can lead to organ failure. The consequence is often the need for a transplant. The number of performed operations is very low due to the shortage of organs for transplantation.
Hryhorowicz, Magdalena, Lipiński, Daniel, Mazurkiewicz, Natalia, Nowak, Agnieszka, Słomski, Ryszard, Zeyland, Joanna   +5 more
core   +2 more sources

Considering the Risks and Costs of Solid Organ Xenotransplantation

Advanced Biology, Volume 9, Issue 4, April 2025.
This perspective discusses the rationale, risks, and costs of whole‐organ xenotransplantation. It considers alternative strategies to obviate the demand for transplants and optimize allotransplantation systems and practices that do not impose xenotransplantation's harms and risks, and whether they are the most ethical and effective means to increase ...
Catharine E. Krebs, Janine McCarthy, Kristie Sullivan, James Craner, Brendan Parent, Ann Lam   +5 more
wiley   +1 more source

Preliminary PCR-based screening indicates a higher incidence of Porcine Endogenous Retrovirus subtype C (PERV-C) in feral versus domestic swine [PDF]

, 2019
Xenotransplantation is considered a potential alternative to allotransplantation to relieve the current shortage of human organs. Due to their similar size and physiology, the organs of pigs are of particular interest for this purpose.
Acharya, Rashmi, Gillock, Eric T., Keener, Robert, Wallis, Zoey K.   +3 more
core   +1 more source

Recreating the Endocrine Niche: Advances in Bioengineering the Pancreas

Artificial Organs, Volume 49, Issue 4, Page 541-555, April 2025.
During the isolation process, islets are disconnected from their extracellular matrix and vasculature, leading to significant islet loss and poor graft function. This review covers various strategies developed to produce the building blocks for generating a vascularized, immune‐protected insulin‐secreting construct, emphasizing the importance of the ...
Laura Mar Fonseca, Nicerine Krause, Fanny Lebreton, Ekaterine Berishvili   +3 more
wiley   +1 more source

Immunometabolism of Liver Xenotransplantation and Prospective Solutions

Advanced Science, Volume 12, Issue 9, March 6, 2025.
After xenotransplantation, pig livers will replace those of human patients to maintain the stability of metabolism and immune system. The incompatibility of immunometabolism between humans and pigs induces rejection, inflammation, coagulation dysfunction, and liver failure. The profile of immunometabolism pre‐transplantation and post‐transplantation is
Shoulong Deng, Yi Zhang, Shasha Shen, Chongyang Li, Chuan Qin   +4 more
wiley   +1 more source

Distribution Of Porcine Endogenous Retrovirus (PERV) Variants In Domestic And Feral Pig [PDF]

, 2018
Xenotransplantation is considered an alternative to allotransplantation to relieve the current shortage of human organs. Due to their similar size and physiology, the organs of pigs are of particular interest for this purpose. Endogenous retroviruses are
Acharya, Rashmi
core   +1 more source

Insertional Variations of Two Porcine Endogenous Retroviruses (PERVs) in Korean Native Pigs and Asian Wild Boars

Asian-Australasian Journal of Animal Sciences, 2007
Porcine Endogenous Retroviruses (PERVs) are a major concern in relation to xenotransplantation. Previous research indicated that PERVs are present at about 50 copies in the pig genome and their chromosomal insertion sites are different among pig breeds.
Jung, K.C., Yu, S.L., Kim, Thi Chantha, Jeon, J.T., Rogel Gaillard, Claire, Park, C.S., Jin, D.I., Moran, Christopher, Lee, J.H.   +8 more
openaire   +2 more sources