Results 81 to 90 of about 515,911 (152)

Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α

Journal of General Virology, 2009
The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5α molecules despite the fact that they strongly restrict a variety of divergent lentiviruses.
Wood, A., Webb, B. L. J., Bartosch, B., Schaller, T., Takeuchi, Y., Towers, G. J.   +5 more
openaire   +3 more sources

Distribution of porcine endogenous retroviruses (PERVs) DNA in organs of a domestic pig.

Annals of transplantation, 2005
Domestic pig may serve as the most appropriate organ source for human xenotransplantation in the future. However, there is a serious threat of xenogeneic pathogens transmission, especially porcine endogenous retroviruses (PERVs) which are present in genomes of all pigs. The aim of this study was to monitor the prevalence and distribution of PERV DNA in
Daniel, Sypniewski, Grzegorz, Machnik, Urszula, Mazurek, Tadeusz, Wilczok, Zdzisław, Smorag, Jacek, Jura, Barbara, Gajda   +6 more
openaire   +1 more source

Role of DNA methylation in expression and transmission of porcine endogenous retroviruses

, 2013
Porcine endogenous retroviruses (PERV) represent a major safety concern in pig-to-human xenotransplantation. To date, no PERV infection of a xenograft recipient has been recorded; however, PERVs are transmissible to human cells in vitro.
Scobie, Linda, Mattiuzzo, Giada, Hector, Ralph D., Takeuchi, Yasuhiro, Vesely, Pavel, Hejnar, Jirˇí, Matouskova, Magda, Daniel, Petr, Scobie, Linda; id_orcid   +8 more
core   +1 more source

The role of human SAMHD1 in restricting porcine endogenous retroviruses (PERVs) and the innate immune response to PERV infection in human primary immune cells

, 2020
Die Freisetzung von Porcinen Endogenen Retroviren (PERVs) aus Schweinezellen ist ein potenzieller Risikofaktor während der Xenotransplantation. PERV ist in der Lage, in humanen Zelllinien zu replizieren. Mögliche Abwehrmechanismen gegen die PERV-Replikation sind zelluläre Restriktionsfaktoren.
openaire   +3 more sources

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

, 2017
Xenotransplantation is a promising strategy to alleviate the shortage of organs for human transplantation. In addition to the concerns about pig-to-human immunological compatibility, the risk of cross-species transmission of porcine endogenous ...
I-Hsiu Lee, Yubo Qing, Zhao, Hong-Ye, Kan, Yinan, Wang, Gang, Wang, Tao, Hong-Jiang Wei, Wang, Yong, Lin, Lin, Lesha, Emal, Gang Wang, Luhan Yang, Haydy George, Qing, Yubo, Emal Lesha, Hong-Ye Zhao, Wang, Shouqi, Hong Wei, Lin Lin, George M. Church, Luo, Yonglun, Güell Cargol, Marc, 1982-, Dong Niu, Wei, Hong-Jiang, Tao Wang, Yinan Kan, Niu, Dong, Jiao, Deling, Zhou, Xiaoyang, Heng Zhao, Shrock, Ellen, Zhao, Heng, Church, George M., Shouqi Wang, Xiaoyang Zhou, Lee, I-Hsiu, Yonglun Luo, Deling Jiao, Yong Wang, George, Haydy, Yang, Luhan, Ellen Shrock, Marc Güell   +42 more
core   +1 more source

Investigation of interactions between porcine endogenous retroviruses (PERV) and susceptible host cells

Die Xenotransplantation (XTx) vom Schwein auf den Menschen hat das Potenzial, den Mangel an menschlichen Allotransplantaten zu beheben. Trotz der erheblichen Fortschritte der letzten Jahre kann das zoonotische Risiko durch die potenzielle Übertragung porziner endogener Retroviren (PERVs) nicht ausgeschlossen werden. Im Gegensatz zu den meisten porzinen
openaire   +2 more sources

No transmission of porcine endogenous retroviruses (PERVs) in a long-term pig to rat xenotransplantation model and no infection of immunosuppressed rats.

Annals of transplantation, 2008
Xenotransplantation from pig to humans may be associated with the risk of transmission of porcine endogenous retroviruses (PERVs) that are present in the genome of all pigs and that infect human cells in vitro. However, it remains unclear whether PERVs infect transplant recipients in vivo and, if so, whether they are pathogenic.
Joachim, Denner, Volker, Specke, Alexander, Karlas, Irina, Chodnevskaja, Thomas, Meyer, Vasiliy, Moskalenko, Reinhard, Kurth, Karin, Ulrichs   +7 more
openaire   +1 more source

VII In Silico Expression Profiles of Human

, 2008
Final manuscript version of an article published as: Merja Oja.
Endogenous Retroviruses, Merja Oja
core  

The significance of porcine replication defect endogenous retroviruses in xenotransplantation

, 2014
The shortage of human tissues and organs for allotransplantation can be overcome by xenotransplantation. As a source of organs, the miniature pig is convenient.
Daniel, Petr
core  

The Transmembrane Envelope Protein of Porcine Endogenous Retroviruses Modulates Cytokine Release and Gene Expression in Human Immune Cells

Porcine endogenous retroviruses (PERVs), their transmembrane envelope protein p15E and peptides corresponding to a highly conserved among all retroviruses domain in p15E, the immunosuppressive (isu) domain, demonstrated immunosuppressive properties. They
Fatih Noyan, Antje Brinkmann, Joachim Denner, Maike Quotschalla, Reinhard Schwinzer, Jinzhao Ban, Ludwig Krabben, Sebastian Rausch, Benedikt B. Kaufer, Andrea Schienke   +9 more
core   +1 more source