Results 51 to 60 of about 515,911 (152)

Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5  proteins including human TRIM5 [PDF]

, 2009
The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5{
Takeuchi, Y., Schaller, T., Towers, G. J., Wood, A., Webb, B. L. J., Bartosch, B.   +5 more
core  

Characterising and Mapping Porcine Endogenous Retroviruses (PERVs) [PDF]

, 2001
The initial focus of this PhD project was on comparative gene mapping. Comparative gene mapping is facilitated by consensus PCR primers which amplify homologous gene fragments in many species.
Lee, Jun Heon
core  

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, Volume 13, Issue 49, 3 September 2026.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

Porcine Endogenous Retroviruses PERV-A and PERV-B Infect neither Mouse Cells in vitro nor SCID Mice in vivo

Intervirology, 2005
<i>Objective:</i> Porcine endogenous retroviruses (PERVs) pose a risk for xenotransplantations using pig materials as they are present in the genome of all pigs and are able to infect human cells in vitro. Until recently, transmission of PERVs in vivo was only described in severe combined immunodeficient (SCID) and nude mice inoculated with
Markus, Irgang, Alexander, Karlas, Christine, Laue, Volker, Specke, Stefan J, Tacke, Reinhard, Kurth, Jurgen, Schrezenmeir, Joachim, Denner   +7 more
openaire   +2 more sources

Cell entry and exit of porcine endogenous retrovirus A: receptors and release inhibitor [PDF]

, 2010
Following the discovery that porcine endogenous retrovirus (PERV) can infect human cells, the potential risk of a zoonotic infection by PERV has been a major obstacle in the xenotransplantation field.
Mattiuzzo, G.
core  

Xenotransplantation of the Porcine Lung—From Immunological Barriers to Emerging Experimental Strategies

Xenotransplantation, Volume 33, Issue 5, September/October 2026.
ABSTRACT Lung transplantation is the only long‐lasting life‐saving treatment for patients with end‐stage pulmonary disease, but the ever‐growing shortage of suitable donor organs leads to high mortality rates of the afflicted patients. Xenotransplantation, the transplantation of organs across species, has emerged as a promising alternative. This review
Nathalie Roters, Niveditha Varma, Robert Ramm, Heiner Niemann, Patrick Zardo, Arjang Ruhparwar, Tobias Goecke   +6 more
wiley   +1 more source

Characterizing and mapping porcine endogenous retroviruses in Westran pigs

, 2002
Since porcine endogenous retroviruses (PERVs) can infect cultured human cells, they are a potential hazard to xenotransplantation. For this reason, endogenous retroviruses from the Westran (Westmead Hospital transplantation) inbred line of pigs were ...
Lee, J., Jun-Heon Lee, Allen, R., Richard D. M. Allen, Webb, G., Moran, C., Chris Moran, Graham C. Webb   +7 more
core   +1 more source

The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases [PDF]

, 2009
A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Master of PhilosophyHuman endogenous retroviruses (HERVs) are estimated to form approximately 5% of the human genome.
Smith, Richard G.
core   +3 more sources

Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR‐Based β‐Cell Replacement and Treg Immune Modulation Approaches

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5476-5491, July 2026.
ABSTRACT Background Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease marked by the destruction of pancreatic β‐cells, resulting in lifelong dependence on exogenous insulin. Despite advances in insulin delivery and glucose monitoring technologies, patients remain at risk for acute and long‐term complications, underscoring the need for ...
Tzu‐Min Lin, Hui‐Fang Chang, Tzu‐Ching Lin, Cheng‐Han Lin, Yu‐Ling Sun, Chih‐Sheng Lin   +5 more
wiley   +1 more source

A Comprehensive Strategy for Screening for Xenotransplantation-Relevant Viruses in a Second Isolated Population of Göttingen Minipigs

Viruses, 2019
Xenotransplantation using pig tissues and organs is under development in order to alleviate the increasing shortage of human transplants. Since xenotransplantation may be associated with the transmission of porcine microorganisms to the human recipient ...
Luise Krüger, Yannick Kristiansen, Emelie Reuber, Lars Möller, Michael Laue, Christian Reimer, Joachim Denner   +6 more
doaj   +1 more source