Results 11 to 20 of about 110,621 (200)

Approaches to PET Imaging of Glioblastoma

Molecules, 2020
Glioblastoma multiforme (GBM) is the deadliest type of brain tumor, affecting approximately three in 100,000 adults annually. Positron emission tomography (PET) imaging provides an important non-invasive method of measuring biochemically specific targets
Lindsey R. Drake, Ansel T. Hillmer, Zhengxin Cai   +2 more
doaj   +2 more sources

Modular strategies for PET imaging agents [PDF]

Current Opinion in Chemical Biology, 2010
In recent years, modular and simplified chemical and biological strategies have been developed for the synthesis and implementation of positron emission tomography (PET) radiotracers. New developments in bioconjugation and synthetic methodologies, in combination with advances in macromolecular delivery systems and gene-expression imaging, reflect a ...
Hooker, Jacob
openaire   +6 more sources

Radiolabeled Silicon-Rhodamines as Bimodal PET/SPECT-NIR Imaging Agents

Pharmaceuticals, 2021
Radiolabeled fluorescent dyes are decisive for bimodal imaging as well as highly in demand for nuclear- and optical imaging. Silicon-rhodamines (SiRs) show unique near-infrared (NIR) optical properties, large quantum yields and extinction coefficients as
Thines Kanagasundaram, Markus Laube, Johanna Wodtke, Carsten Sven Kramer, Sven Stadlbauer, Jens Pietzsch, Klaus Kopka   +6 more
doaj   +2 more sources

Pyrazoles as Key Scaffolds for the Development of Fluorine-18-Labeled Radiotracers for Positron Emission Tomography (PET)

Molecules, 2020
The need for increasingly personalized medicine solutions (precision medicine) and quality medical treatments, has led to a growing demand and research for image-guided therapeutic solutions.
Pedro M. O. Gomes, Artur M. S. Silva, Vera L. M. Silva   +2 more
doaj   +1 more source

PET/CT for Predicting Occult Lymph Node Metastasis in Gastric Cancer

Current Oncology, 2022
A portion of gastric cancer patients with negative lymph node metastasis at an early stage eventually die from tumor recurrence or advanced metastasis.
Danyu Ma, Ying Zhang, Xiaoliang Shao, Chen Wu, Jun Wu   +4 more
doaj   +1 more source

[45Ti]Ti-HOPOs: Potential Complexes for the Development of 45Ti PET Imaging Agents [PDF]

ACS Omega
Shefali Saini, N.V.S. Dinesh K. Bhupathiraju, Samith B. Jayawardana, Michael D. Phipps, Jason S. Lewis, Lynn C. Francesconi, Gayan B. Wijeratne, Melissa A. Deri, Suzanne E. Lapi   +8 more
doaj   +2 more sources

The progress of PET/MRI in clinical management of patients with pancreatic malignant lesions

Frontiers in Oncology, 2023
Recently, the morbidity and mortality of pancreatic cancer have been increasing year by year. Because of its deep anatomical location and because most presented patients often suffer from abdominal pain or jaundice, it is difficult to diagnose pancreatic
Jindan Li, Chaojiang Fu, Sheng Zhao, Yongzhu Pu, Fake Yang, Shuguang Zeng, Conghui Yang, Hongqiang Gao, Long Chen   +8 more
doaj   +1 more source

Radiofluorination of a highly potent ATM inhibitor as a potential PET imaging agent

EJNMMI Research, 2022
Abstract Purpose Ataxia telangiectasia mutated (ATM) is a key mediator of the DNA damage response, and several ATM inhibitors (ATMi) are currently undergoing early phase clinical trials for the treatment of cancer. A radiolabelled ATMi to determine drug pharmacokinetics could assist patient selection in a move towards ...
Fraser, CR, Ajenjo, J, Veal, M, Dias, GM, Chan, C, O’Neill, E, Destro, G, Lau, D, Pacelli, A, Gouverneur, V, Hueting, R, Cornelissen, B   +11 more
openaire   +5 more sources

FDG-PET imaging for the evaluation of antiglioma agents in a rat model [PDF]

Neuro-Oncology, 2008
The increasing development of novel anticancer agents demands parallel advances in the methods used to rapidly assess their therapeutic efficacy (TE) in the preclinical phase. We evaluated the ability of small-animal PET, using the (18)F-fluoro-deoxy-D-glucose (FDG) radiotracer, to predict the TE of a number of anticancer agents in the rat C6 glioma ...
Sarah, Assadian, Antonio, Aliaga, Rolando F, Del Maestro, Alan C, Evans, Barry J, Bedell   +4 more
openaire   +2 more sources

PET Imaging in Animal Models of Alzheimer’s Disease

Frontiers in Neuroscience, 2022
The successful development and translation of PET imaging agents targeting β-amyloid plaques and hyperphosphorylated tau tangles have allowed for in vivo detection of these hallmarks of Alzheimer’s disease (AD) antemortem.
Baosheng Chen, Bernadette Marquez-Nostra, Erika Belitzky, Takuya Toyonaga, Jie Tong, Yiyun Huang, Zhengxin Cai   +6 more
doaj   +1 more source