Results 51 to 60 of about 76,229 (261)

Radiometal-Based PET/MRI Contrast Agents for Sensing Tumor Extracellular pH

Biosensors, 2022
Acidosis is a useful biomarker for tumor diagnoses and for evaluating early response to anti-cancer treatments. Despite these useful applications, there are few methods for non-invasively measuring tumor extracellular pH, and none are routinely used in ...
Alyssa C. Pollard, Jorge de la Cerda, F. William Schuler, Tyler R. Pollard, Aikaterini Kotrotsou, Federica Pisaneschi, Mark D. Pagel   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Evaluations of the performances of PET and MRI in a simultaneous PET/MRI instrument for pre-clinical imaging

EJNMMI Physics, 2022
Background PET/MRI is an attractive imaging modality due to the complementary nature of MRI and PET. Obtaining high quality small animal PET/MRI results is key for the translation of novel PET/MRI agents and techniques to the radiology clinic.
Alyssa C. Pollard, Jorge de la Cerda, F. William Schuler, Charles V. Kingsley, Seth T. Gammon, Mark D. Pagel   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Anesthesia in PET/MRI. Challenges for the Anesthesiologist: A Narrative Review

Journal of Neuroanaesthesiology and Critical Care
Positron emission tomography magnetic resonance imaging (PET/MRI) is an advanced imaging modality that combines metabolic information obtained from PET with anatomical and functional details obtained from MRI.
Sudhir Venkataramaiah, Ramesh J. Venkatapura, Chandana Nagaraj   +2 more
doaj   +1 more source

Granzyme B PET Imaging of the Innate Immune Response

Molecules, 2020
The human immune system is a complex system which protects against invaders and maintains tissue homeostasis. It is broadly divided into the innate and adaptive branches. Granzyme B is serine protease that plays an important role in both and can serve as
Kathleen M. Capaccione, Mikhail Doubrovin, Nikunj Bhatt, Akiva Mintz, Andrei Molotkov   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Applying aryltrifluoroborates as PET imaging agents

, 2013
This dissertation is focused on applying aryltrifluoroborates (ArBF₃s) as PET imaging agents. Several aspects of this new ¹⁸F-labeling technique are addressed. These include the hydrolytic stability of heteroaryltrifluoroborates (HetArBF₃s), the fluoridation of arylboronic acids/esters and the radiosyntheses of several ¹⁸F-ArBF₃ labeled biomolecules ...
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The role of non-FDG agents in PET imaging of bladder cancer

Seminars in Nuclear Medicine
Bladder cancer (BC) poses significant diagnostic challenges for molecular imaging, as [18F]FDG PET/CT demonstrates not only intense urinary excretion that obscures pelvic lesions but also inherently limited diagnostic accuracy in differentiating tumor from inflammation and in detecting small or low-grade lesions.
Alireza Safarian, Dina Muin, Lena Unterrainer, Anton Hörmann, Francesco Mattana, Valentino Dragonetti, Matthias Eiber, Francesco Ceci, Christian Pirich, Mohsen Beheshti   +9 more
openaire   +2 more sources