Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype. [PDF]
PLoS PathogensPlasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a diverse family of variant surface antigens, encoded by var genes, that mediates binding of infected erythrocytes to human cells and plays a key role in parasite immune evasion and malaria
Florence E McLean +9 more
doaj +3 more sources
Acquisition of Fc-afucosylation of PfEMP1-specific IgG is age-dependent and associated with clinical protection against malaria [PDF]
Nature CommunicationsProtective immunity to malaria depends on acquisition of parasite-specific antibodies, with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) being one of the most important target antigens.
Mary Lopez-Perez +8 more
doaj +4 more sources
A monoclonal antibody selectively recognizing PfEMP1 proteins associated with cerebral malaria [PDF]
Scientific ReportsThe frequently fatal outcome of cerebral malaria has been linked to the adhesion and accumulation in the cerebral microvasculature of infected erythrocytes (IEs), which express a particular type of Plasmodium falciparum erythrocyte membrane protein 1 ...
Nanna Dalgaard +12 more
doaj +5 more sources
Serologic responses to the PfEMP1 DBL-CIDR head structure may be a better indicator of malaria exposure than those to the DBL-α tag [PDF]
Malaria Journal, 2019 Background Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to
Emily M. Stucke +24 more
doaj +2 more sources
A system for functional studies of the major virulence factor of malaria parasites [PDF]
eLifePfEMP1 is a variable antigen displayed on erythrocytes infected with the malaria parasite Plasmodium falciparum. PfEMP1 mediates binding of the infected cell to the endothelium of blood vessels, a cause of severe malaria.
Jakob Cronshagen +19 more
doaj +2 more sources
Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes--divide and conquer. [PDF]
PLoS Computational Biology, 2010 The var gene encoded hyper-variable Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediates cytoadhesion of infected erythrocytes to human endothelium.
Thomas S Rask +4 more
doaj +6 more sources
From genomic to LC-MS/MS evidence: Analysis of PfEMP1 in Benin malaria cases. [PDF]
PLoS ONE, 2019 BACKGROUND:PfEMP1 is the major protein from parasitic origin involved in the pathophysiology of severe malaria, and PfEMP1 domain subtypes are associated with the infection outcome.
Claire Kamaliddin +15 more
doaj +2 more sources
Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers. [PDF]
PLoS ONE, 2011 Antibodies to polymorphic antigens expressed during the parasites erythrocytic stages are important mediators of protective immunity against P. falciparum malaria.
Louise Turner +6 more
doaj +3 more sources
Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1. [PDF]
PLoS ONE, 2015 The ABO blood group antigens are expressed on erythrocytes but also on endothelial cells, platelets and serum proteins. Notably, the ABO blood group of a malaria patient determines the development of the disease given that blood group O reduces the ...
Kirsten Moll +4 more
doaj +3 more sources
PLoS Pathogens, 2012 Sequence diversity in pathogen antigens is an obstacle to the development of interventions against many infectious diseases. In malaria caused by Plasmodium falciparum, the PfEMP1 family of variant surface antigens encoded by var genes are adhesion ...
Ashfaq Ghumra +16 more
doaj +2 more sources