Results 11 to 20 of about 6,004 (229)

Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1. [PDF]

PLoS ONE, 2013
Members of the Plasmodium falciparum Erythrocyte Membrane protein 1 (PfEMP1) family expressed on the surface of malaria-infected erythrocytes mediate binding of the parasite to different receptors on the vascular lining.
Sanne S Berger, Louise Turner, Christian W Wang, Jens E V Petersen, Maria Kraft, John P A Lusingu, Bruno Mmbando, Andrea M Marquard, Dominique B A C Bengtsson, Lars Hviid, Morten A Nielsen, Thor G Theander, Thomas Lavstsen   +12 more
doaj   +5 more sources

Breaking the bind: PfEMP1-specific antibodies in cerebral malaria. [PDF]

Front Immunol
Antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) on infected erythrocytes (IEs) play a central role in naturally acquired protection against cerebral malaria (CM), yet the determinants of effective humoral immunity remain incompletely defined.
Banda JP, Walker IS, Nyirenda T, Aitken EH, Rogerson SJ.   +4 more
europepmc   +4 more sources

The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs [PDF]

Malaria Journal, 2010
Background Infected humans make protective antibody responses to the PfEMP1 adhesion antigens exported by Plasmodium falciparum parasites to the erythrocyte membrane, but little is known about the kinetics of this antibody-receptor binding reaction or ...
Arnot David E, Hviid Lars, Hassenkam Tue, Theander Thor G, Barfod Lea, Dobrilovic Tina, Salanti Ali, Joergensen Lars M   +7 more
doaj   +5 more sources

Surface antigens in Plasmodium falciparum malaria : PfEMP1 and SURFIN4.2 [PDF]

PLoS ONE, 2017
Plasmodium falciparum malaria is an infectious disease that on despite of the ongoing eradication efforts is still endemic in more than 100 countries, sometimes causing severe disease that leads to the death of around half a million people per year ...
Quintana Varon, Maria del Pilar
core   +8 more sources

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains [PDF]

EMBO Molecular Medicine, 2016
Most severe Plasmodium falciparum infections are experienced by young children. Severe symptoms are precipitated by vascular sequestration of parasites expressing a particular subset of the polymorphic P. falciparum erythrocyte membrane protein 1 (PfEMP1)
Jakob S Jespersen, Christian W Wang, Sixbert I Mkumbaye, Daniel TR Minja, Bent Petersen, Louise Turner, Jens EV Petersen, John PA Lusingu, Thor G Theander, Thomas Lavstsen   +9 more
doaj   +2 more sources

Revealing the molecular signatures of host-pathogen interactions. [PDF]

, 2011
Advances in sequencing technology and genome-wide association studies are now revealing the complex interactions between hosts and pathogen through genomic variation signatures, which arise from evolutionary co ...
C Herdtweck, C Loscos, C Sik-Lányi, F Yan, G Xing, GJ Ward, H Kolivand, H Kolivand, Hoshang Kolivand, J Blinn, J Hensley, K Jacobs, K Kaneda, K Kilteni, K Tadamura, KL Wilson, Kolivand, L Hosek, M Aittala, M Haller, M Kanbara, M Knecht, M Slater, M Sunar, Mohd Shahrizal Sunar, MS Sunar, MZ Shao, N Greene, P Debevec, R Azuma, R Ji, R Ji, R Kittler, R Kittler, R Kittler, R Klassen, R Perez, RC Yeoh, Rongrong Ji, S Gibson, S Lee, T Annen, T Guan, T Naemura, T Nishita, W Donnelly, W Hartmann, W Reeves, Y Dobashi, Y Dobashi, Y Feng, Y Liu, Y Liu, Z Noh   +53 more
core   +29 more sources

PfEMP1-Specific Immunoglobulin G Reactivity Among Beninese Pregnant Women With Sickle Cell Trait [PDF]

Open Forum Infectious Diseases, 2021
Abstract Background Sickle cell trait (HbAS) protects against severe Plasmodium falciparum malaria but not against placental malaria (PM). In this study, P falciparum erythrocyte membrane protein (PfEMP1)-specific antibodies were measured in HbAA and HbAS Beninese pregnant women as a proxy of exposure
Mary Lopez-Perez, Firmine Viwami, Zakaria Seidu, Anja T. R. Jensen, Justin Doritchamou, Nicaise Tuikue Ndam, Lars Hviid   +6 more
openalex   +5 more sources

Regulation of PfEMP1–VAR2CSA translation by a Plasmodium translation-enhancing factor

Nature Microbiology, 2017
Pregnancy-associated malaria commonly involves the binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate A (CSA) through the PfEMP1-VAR2CSA protein. VAR2CSA is translationally repressed by an upstream open reading frame. In this study, we report that the P.
Sherwin Chan, Alejandra Frasch, Chandra Sekhar Mandava, Jun-Hong Ch’ng, María del Pilar Quintana, Mattias Vesterlund, Mehdi Ghorbal, Nicolas Joannin, Oscar Franzén, José-Juan Lopez-Rubio, Sonia Barbieri, Antonio Lanzavecchia, Suparna Sanyal, Mats Wahlgren   +13 more
openalex   +5 more sources

The role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis research [PDF]

Molecular and Biochemical Parasitology, 2014
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family has a key role in parasite survival, transmission, and virulence. PfEMP1 are exported to the erythrocyte membrane and mediate binding of infected erythrocytes to the endothelial lining of blood vessels.
Joseph D. Smith
openalex   +4 more sources

A Systematic Targeted Genetic Screen Identifies Proteins Involved in Cytoadherence of the Malaria Parasite P. falciparum. [PDF]

Mol Microbiol
In silico workflow for selection of genes targeted in this study. We have identified a number of proteins involved in host cell modification by malaria parasites. Furthermore, we highlight a number of genes that appear to be essential for blood‐stage survival of these parasites.
Küster N, Roling L, Ouayoue A, Steeg K, Przyborski JM.   +4 more
europepmc   +2 more sources