Results 21 to 30 of about 6,004 (229)

Immune Modulation by Plasmodium yoelii: Insights From Lethal and Non-Lethal Strains. [PDF]

Parasite Immunol
ABSTRACT Malaria pathogenesis is driven by intricate host–parasite interactions that determine immune balance and clinical outcome. The Plasmodium yoelii model, particularly its lethal (17XL) and non‐lethal (17XNL) strains, provides a robust framework to investigate these dynamics.
Lim SYM.
europepmc   +2 more sources

Differential PfEMP1 Expression Is Associated with Cerebral Malaria Pathology [PDF]

PLoS Pathogens, 2014
Plasmodium falciparum est unique parmi les paludisme humains dans sa capacité à séquestrer dans les veinules post-capillaires des organes hôtes. Les principaux antigènes variants impliqués sont la protéine membranaire 1 des érythrocytes de P. falciparum (PfEMP1), qui peut être divisée en trois groupes principaux (A-C).
Dumizulu Tembo, Benjamin N Nyoni, Rekah V. Murikoli, Mavuto Mukaka, Danny A. Milner, Matthew Berriman, Stephen J. Rogerson, Terrie E. Taylor, Malcolm E. Molyneux, Wilson L. Mandala, Alister G. Craig, Jacqui Montgomery   +11 more
openaire   +6 more sources

Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite. [PDF]

Traffic
This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Miao J, Lucky AB, Ning G, Xia X, Liang X, Siddiqui F, Min H, Wang C, Li X, Zhou ZH, Cui L.   +10 more
europepmc   +2 more sources

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it [PDF]

Immunological Reviews, 2019
AbstractMalaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites have the unique capacity to infect and replicate within host erythrocytes.
Anja Ramstedt Jensen, Yvonne Adams, Lars Hviid   +2 more
openaire   +4 more sources

In Vitro Variant Surface Antigen Expression in Plasmodium falciparum Parasites from a Semi-Immune Individual Is Not Correlated with Var Gene Transcription. [PDF]

PLoS ONE, 2016
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is considered to be the main variant surface antigen (VSA) of Plasmodium falciparum and is mainly localized on electron-dense knobs in the membrane of the infected erythrocyte.
Ellen Inga Bruske, Sandra Dimonte, Corinna Enderes, Serena Tschan, Matthias Flötenmeyer, Iris Koch, Jürgen Berger, Peter Kremsner, Matthias Frank   +8 more
doaj   +1 more source

PfEMP1’s Magical Embrace of EPCR [PDF]

Cell Host & Microbe, 2015
Since discovering PfEMP1 virulence proteins in Plasmodium falciparum, malariologists have struggled to reconcile their limitless sequence diversity with their binding to relatively few host receptors. In this issue of Cell Host & Microbe, Lau et al.
openaire   +4 more sources

THE CIDR1α-PfEMP1 SEQUENCE FROM INDONESIAN PLASMODIUM FALCIPARUM AND ITS POTENTIAL ASSOCIATION WITH THE CEREBRAL OUTCOME

Malang Neurology Journal, 2021
Background: Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is an important protein responsible for the pathogenesis of severe malaria, including cerebral malaria. The protein is highly diverse.
Erma Sulistyaningsih, Yunita Armiyanti, Rosita Dewi   +2 more
doaj   +1 more source

Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation

Scientific Reports, 2021
Plasmodium falciparum erythrocyte membrane protein-1s (PfEMP1s), diverse malaria proteins expressed on the infected erythrocyte surface, play an important role in pathogenesis, mediating adhesion to host vascular endothelium. Antibodies to particular non-
Noah T. Ventimiglia, Emily M. Stucke, Drissa Coulibaly, Andrea A. Berry, Kirsten E. Lyke, Matthew B. Laurens, Jason A. Bailey, Matthew Adams, Amadou Niangaly, Abdoulaye K. Kone, Shannon Takala-Harrison, Bourema Kouriba, Ogobara K. Doumbo, Phillip L. Felgner, Christopher V. Plowe, Mahamadou A. Thera, Mark A. Travassos   +16 more
doaj   +1 more source

Structure-guided design of a synthetic mimic of an EPCR-binding PfEMP1 protein [PDF]

Cell Host & Microbe, 2019
Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM). However, the mechanisms leading to swelling remain poorly defined. Here, we combined neuroimaging, parasite transcript profiling, and laboratory blood profiles to develop machine-learning models of malarial retinopathy and brain swelling.
Natalie M. Barber, Clinton K. Lau, Louise Turner, G. M. Watson, Susan Thrane, John Lusingu, Thomas Lavstsen, Matthew K. Higgins   +7 more
openalex   +4 more sources

Identification of Plasmodium falciparum var1CSA and var2CSA domains that bind IgM natural antibodies [PDF]

, 2006
Malaria in pregnancy is responsible for maternal anaemia, low-birth-weight babies and infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental pathology by adhering to host receptors such as chondroitin sulphate A (CSA ...
Ahmed Raza, Atalay, Baruch, Baruch, Buffet, Chen, Chen, Chitnis, Cohen, Cooke, Craig, Creasey, Fagan, Flick, Fried, Gamain, Gamain, Gardner, Guyatt, J. Alexandra Rowe, Jean-Philippe Semblat, Kyes, Kyes, Langone, Lin, Mayor, Medina, Medina, Rowe, Rowe, Rowe, Salanti, Salanti, Scholander, Smith, Smith, Su, Sue A. Kyes   +37 more
core   +1 more source