Interaction Analysis of a Plasmodium falciparum PHISTa-like Protein and PfEMP1 Proteins [PDF]
Frontiers in Microbiology, 2020 Plasmodium falciparum extensively remodels host cells by translocating numerous proteins into the cytoplasm of red blood cells (RBCs) after invasion. Among these exported proteins, members of the Plasmodium helical interspersed subtelomeric (PHIST) family are crucial for host cell remodeling and host-parasite interactions, and thereby contribute to ...
Baoling Yang +7 more
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Architecture of Human IgM in Complex with P. falciparum Erythrocyte Membrane Protein 1
Cell Reports, 2016 Plasmodium falciparum virulence is associated with sequestration of infected erythrocytes. Microvascular binding mediated by PfEMP1 in complex with non-immune immunoglobulin M (IgM) is common among parasites that cause both severe childhood malaria and ...
Reetesh Raj Akhouri +4 more
doaj +1 more source
Recent advances in malaria genomics and epigenomics [PDF]
, 2016 Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian +2 more
core +1 more source
Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting Plasmodium falciparum cytoadherence [PDF]
Proceedings of the National Academy of Sciences, 2021 Significance Mature asexual stages of Plasmodium falciparum -infected erythrocytes (IEs) bind to endothelium to avoid splenic clearance. The PfEMP1 family is the major cytoadhesion ligand at the IE surface and is essential for parasite sequestration. In this study, we show that complement component 1s (C1s)
Yvonne Azasi +11 more
openaire +4 more sources
Default Pathway of var2csa switching and translational repression in Plasmodium falciparum. [PDF]
PLoS ONE, 2008 Antigenic variation is a subtle process of fundamental importance to the survival of a microbial pathogen. In Plasmodium falciparum malaria, PfEMP1 is the major variable antigen and adhesin expressed at the surface of the infected erythrocyte, which is ...
Bobo W Mok +6 more
doaj +1 more source
Common virulence gene expression in adult first-time infected malaria patients and severe cases
eLife, 2021 Sequestration of Plasmodium falciparum(P. falciparum)-infected erythrocytes to host endothelium through the parasite-derived P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion proteins is central to the development of malaria pathogenesis ...
J Stephan Wichers +20 more
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Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study [PDF]
, 2006 Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a major pathogenicity factor in falciparum malaria that mediates cytoadherence. PfEMP1 is encoded by approximately 60 var genes per haploid genome.
Baea, Kay +5 more
core +1 more source
Frontiers in Immunology, 2019 Members of the PfEMP1 protein family are expressed on the surface of P. falciparum-infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are important targets of acquired immunity.
Mads Delbo Larsen +8 more
doaj +1 more source
Jurnal Ilmu Dasar, 2020 The binding of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) to Intracellular Adhesion Molecule-1 (ICAM-1) is a major pathological mechanism in severe malaria including cerebral malaria. The binding is mediated by PfEMP1-DBL2β domain. The
Fathul Hidayatul Hasanah +2 more
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The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure. [PDF]
PLoS Pathogens, 2008 Plasmodium falciparum malaria parasites, living in red blood cells, express proteins of the erythrocyte membrane protein-1 (PfEMP1) family on the red blood cell surface.
Michael M Klein +7 more
doaj +1 more source