Results 51 to 60 of about 6,004 (229)

Immunity to Severe Malaria: PfEMP1 Tags Tell a Tale [PDF]

Cell Host & Microbe, 2019
PfEMP1 is the major surface antigen of P. falciparum-infected erythrocytes, mediates endothelial adhesion, and displays extreme sequence diversity that underpins antigenic variation. In this issue of Cell Host & Microbe, Tessema et al. (2019) find that antibodies in sera from a pediatric cohort that bind a discrete PfEMP1 subset associate with ...
openaire   +2 more sources

Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria [PDF]

EMBO reports, 2022
Plasmodium falciparum, the deadliest form of human malaria, remains one of the major threats to human health in endemic regions. Its virulence is attributed to its ability to modify infected red blood cells (iRBC) to adhere to endothelial receptors by placing variable antigens known as PfEMP1 on the iRBC surface.
Tamir Zelter, Jacob Strahilevitz, Karina Simantov, Olga Yajuk, Yvonne Adams, Anja Ramstedt Jensen, Ron Dzikowski, Zvi Granot   +7 more
openaire   +3 more sources

T-cell responses to the DBLα-tag, a short semi-conserved region of the Plasmodium falciparum membrane erythrocyte protein 1.

PLoS ONE, 2012
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a variant surface antigen expressed on mature forms of infected erythrocytes. It is considered an important target of naturally acquired immunity.
Evelyn N Gitau, James Tuju, Liz Stevenson, Eva Kimani, Henry Karanja, Kevin Marsh, Peter C Bull, Britta C Urban   +7 more
doaj   +1 more source

Cytoadhesion to gC1qR through Plasmodium falciparum Erythrocyte Membrane Protein 1 in Severe Malaria [PDF]

, 2016
Cytoadhesion of Plasmodium falciparum infected erythrocytes to gC1qR has been associated with severe malaria, but the parasite ligand involved is currently unknown.
Aide, Pedro Carlos Paulino, Alonso, Pedro, Bassat Orellana, Quique, Chitnis, Chetan E., Cisteró, Pau, Gascón i Brustenga, Joaquim, Gupta, Himanshu, Jiménez, Alfons, Lavstsen, Thomas, Macete, Eusebio Víctor, Machevo, Sonia, Magallón Tejada, Ariel, Mandomando, Inácio, Mayor Aparicio, Alfredo Gabriel, Muñoz, José, Petersen, Jens E. V, Rubio, Mercedes, Salas, Briege de las, Turner, Louise, Valmaseda, Aida, Wang, Christian W.   +20 more
core   +3 more sources

Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cells. [PDF]

PLoS ONE, 2007
BACKGROUND: Host innate immunity contributes to malaria clinical outcome by providing protective inflammatory cytokines such as interferon-gamma, and by shaping the adaptive immune response.
Myriam Baratin, Sophie Roetynck, Bruno Pouvelle, Céline Lemmers, Nicola K Viebig, Sofia Johansson, Philippe Bierling, Artur Scherf, Jürg Gysin, Eric Vivier, Sophie Ugolini   +10 more
doaj   +1 more source

Children with cerebral malaria or severe malarial anaemia lack immunity to distinct variant surface antigen subsets [PDF]

, 2018
Variant surface antigens (VSAs) play a critical role in severe malaria pathogenesis. Defining gaps, or “lacunae”, in immunity to these Plasmodium falciparum antigens in children with severe malaria would improve our understanding of vulnerability to ...
A Bengtsson, A Claessens, A Djimde, A Salanti, A Salanti, BP Goncalves, C Lessa-Aquino, CI Newbold, CJ Treutiger, CW Wang, D Coulibaly, DH Davies, DI Baruch, F Lennartz, GI Bertin, GK Cham, GM Warimwe, HM Kyriacou, JA Chan, JA Chan, JD Smith, JT Griffin, K Marsh, KE Lyke, KE Lyke, L Turner, M Avril, M Fried, MA Travassos, MA Travassos, MJ Gardner, PD Crompton, RW Snow, S Gupta, SC Murphy, Severe falciparum malaria, SJ Rogerson, SS Oh, T Lavstsen, TE Taylor, TW Mwangi, XZ Su, Y Zhang   +42 more
core   +2 more sources

ICAM-1-binding Plasmodium falciparum erythrocyte membrane protein 1 variants elicits opsonic-phagocytosis IgG responses in Beninese children

Scientific Reports, 2022
Members of the highly polymorphic Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family expressed on the surface of infected erythrocytes (IEs) are important virulence factors, which mediate vascular adhesion of IEs via endothelial host ...
Jennifer Suurbaar, Azizath Moussiliou, Rachida Tahar, Rebecca W. Olsen, Yvonne Adams, Nanna Dalgaard, Eric K. Baafour, Selorme Adukpo, Lars Hviid, Kwadwo A. Kusi, Jules Alao, Michael F. Ofori, Nicaise T. Ndam, Anja R. Jensen   +13 more
doaj   +1 more source

High throughput functional assays of the variant antigen PfEMP1 reveal a single domain in the 3D7 Plasmodium falciparum genome that binds ICAM1 with high affinity and is targeted by naturally acquired neutralizing antibodies. [PDF]

PLoS Pathogens, 2009
Plasmodium falciparum-infected erythrocytes bind endothelial receptors to sequester in vascular beds, and binding to ICAM1 has been implicated in cerebral malaria. Binding to ICAM1 may be mediated by the variant surface antigen family PfEMP1: for example,
Andrew V Oleinikov, Emily Amos, Isaac Tyler Frye, Eddie Rossnagle, Theonest K Mutabingwa, Michal Fried, Patrick E Duffy   +6 more
doaj   +1 more source

Serological Conservation of Parasite-Infected Erythrocytes Predicts Plasmodium falciparum Erythrocyte Membrane Protein 1 Gene Expression but Not Severity of Childhood Malaria. [PDF]

, 2016
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), expressed on P. falciparum-infected erythrocytes, is a major family of clonally variant targets of naturally acquired immunity to malaria.
Abdi, Abdirahman I, Bull, Peter C, Fegan, Gregory, Marsh, Kevin, Musyoki, Jennifer N, Muthui, Michelle, Warimwe, George M   +6 more
core   +2 more sources

MOLECULAR-GENETIC MECHANISMS OF PLASMODIUM FALCIPARUM VIRULENCE AND TROPICAL MALARIA PATHOGENESIS

Журнал инфектологии, 2018
There is introduced the analysis of molecular-genetic mechanisms of tropical malaria pathogenesis and P. falciparum virulence. It is shown, that pathogenesis of tropical malaria is associated with the properties of red blood cells membrane surface (RBCs ...
A. N. Uskov, A. I. Soloviev, V. Yu. Kravtsov, R. V. Gudkov, E. V. Kolomoets, A. E. Levkovskiy   +5 more
doaj   +1 more source