Results 61 to 70 of about 6,004 (229)

Clag9 is not essential for PfEMP1 surface expression in non-cytoadherent Plasmodium falciparum parasites with a chromosome 9 deletion. [PDF]

PLoS ONE, 2011
BACKGROUND: The expression of the clonally variant virulence factor PfEMP1 mediates the sequestration of Plasmodium falciparum infected erythrocytes in the host vasculature and contributes to chronic infection.
Adéla Nacer, Emeric Roux, Sébastien Pomel, Christine Scheidig-Benatar, Hiroshi Sakamoto, Frank Lafont, Artur Scherf, Denise Mattei   +7 more
doaj   +1 more source

Total Leukocyte Count in Rattus norvegicus after Duffy Binding-Like 2β-Plasmodium falciparum Erythrocyte Membrane Protein 1 Recombinant Protein Injection: The way to a Peptide-based Malaria Vaccine Development

Biomolecular and Health Science Journal, 2022
Introduction: Severe malaria caused by Plasmodium falciparum is mediated by the P. falciparum erythrocyte membrane protein 1 (PfEMP1). It has a DBL2β domain that specifically binds to the intercellular adhesion molecule-1 (ICAM-1) receptor that lies in ...
Dwi Ari Santi Putri, Erma Sulistyaningsih, Irawan Fajar Kusuma, Rosita Dewi   +3 more
doaj   +1 more source

DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families [PDF]

, 2013
Many bacterial, viral and parasitic pathogens undergo antigenic variation to counter host immune defense mechanisms. In Plasmodium falciparum, the most lethal of human malaria parasites, switching of var gene expression results in alternating expression ...
Adam F. Sander, Ali Salanti, Anders Gorm Pedersen, Babiker, Barry, Bikard, Boothroyd, Bopp, Bull, Dahlback, Dahlback, David E. Arnot, DePristo, Dharia, Duffy, Eckert-Boulet, Flick, Frank, Freitas-Junior, Gardner, Germann, Giaever, Gietz, Goecks, Guinet, Hastings, Hernandez-Rivas, Higgins, Horn, Jackson, Jakob S. Jespersen, Jiang, Joannin, Kim, Kirk W. Deitsch, Kraemer, Kraemer, Kyes, Lavstsen, Lavstsen, Leach, Lettier, Li, Li, Lorenz, Michael Lisby, Nickoloff, Ohshima, Paek, Paul, Payen, Rask, Rask, Richard Carter, Rowe, Salanti, Sander, Sarah L. Fordyce, Scherf, Sinden, Singh, Smith, Smith, Smith, Smith, Soerli, Su, Su, Taylor, Thomas Lavstsen, Thomas S. Rask, Thor G. Theander, Trager, Turner, Vaidya, Walliker, Ward, Zakov   +77 more
core   +2 more sources

Erythrocyte miRNA-92a-3p interactions with PfEMP1 as determinants of clinical malaria

Functional & Integrative Genomics, 2023
AbstractBased on the recently added high throughput analysis data on small noncoding RNAs in modulating disease pathophysiology of malaria, we performed an integrative computational analysis for exploring the role of human-host erythrocytic microRNAs (miRNAs) and their influence on parasite survival and host homeostasis.
Prabhu, Sowmya R., Ware, Akshay Pramod, Umakanth, Shashikiran, Hande, Manjunath, Mahabala, Chakrapani, Saadi, Abdul Vahab, Satyamoorthy, Kapaettu   +6 more
openaire   +2 more sources

Convalescent Plasmodium falciparum-specific seroreactivity does not correlate with paediatric malaria severity or Plasmodium antigen exposure

Malaria Journal, 2018
Background Antibody immunity is thought to be essential to prevent severe Plasmodium falciparum infection, but the exact correlates of protection are unknown.
Anne Kessler, Joseph J. Campo, Visopo Harawa, Wilson L. Mandala, Stephen J. Rogerson, Wenzhu B. Mowrey, Karl B. Seydel, Kami Kim   +7 more
doaj   +1 more source

Structural analysis of P. falciparum KAHRP and PfEMP1 complexes with host erythrocyte spectrin suggests a model for cytoadherent knob protrusions.

PLoS Pathogens, 2017
Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) and Knob-associated Histidine-rich Protein (KAHRP) are directly linked to malaria pathology. PfEMP1 and KAHRP cluster on protrusions (knobs) on the P.
Erin E Cutts, Niklas Laasch, Dirk M Reiter, Raphael Trenker, Leanne M Slater, Phillip J Stansfeld, Ioannis Vakonakis   +6 more
doaj   +1 more source

Artificial intelligence‐powered microscopy: Transforming the landscape of parasitology

Journal of Microscopy, EarlyView.
Abstract Microscopy and image analysis play a vital role in parasitology research; they are critical for identifying parasitic organisms and elucidating their complex life cycles. Despite major advancements in imaging and analysis, several challenges remain. These include the integration of interdisciplinary data; information derived from various model
Mariana De Niz, Sara Silva Pereira, David Kirchenbuechler, Leandro Lemgruber, Constadina Arvanitis   +4 more
wiley   +1 more source

Erythrocyte Membrane Protein 3 (EMAP3) Is Exposed on the Surface of the Plasmodium berghei Infected Red Blood Cell

Molecular Microbiology, EarlyView.
Erythrocyte membrane protein 3 (EMAP3) is a novel Plasmodium berghei protein that is trafficked to the outer membrane surface of the infected red blood cell (iRBC). EMAP3 is not critical for parasite growth or sequestration but offers a new scaffold for displaying Plasmodium falciparum proteins on iRBCs.
Sophia Raine C. Hernandez, Ravish Rashpa, Thorey K. Jonsdottir, Martina S. Paoletta, Josy ter Beek, María Rayón Díaz, Jelte M. M. Krol, Severine Chevalley‐Maurel, Takahiro Ishizaki, Ronnie P.‐A. Berntsson, Chris J. Janse, Blandine Franke‐Fayard, Mathieu Brochet, Ellen S. C. Bushell   +13 more
wiley   +1 more source

Functional analysis of monoclonal antibodies against the Plasmodium falciparum PfEMP1-VarO adhesin [PDF]

Malaria Journal, 2016
Rosetting, namely the capacity of the Plasmodium falciparum-infected red blood cells to bind uninfected RBCs, is commonly observed in African children with severe malaria. Rosetting results from specific interactions between a subset of variant P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesins encoded by var genes, serum components and RBC
Guillotte, Micheline, Nato, Farida, Juillerat, Alexandre, Hessel, Audrey, Marchand, Françoise, Lewit-Bentley, Anita, Bentley, Graham, Vigan-Womas, Inès, Mercereau-Puijalon, Odile   +8 more
openaire   +3 more sources

Evaluation of Kidney Proximal Tubule Following Immunization with Plasmodium falciparum CIDR1α-PfEMP1 Recombinant Protein in Rats

Majalah Kedokteran Bandung
Malaria vaccines are continuously explored as an approach to eradicate malaria. The cysteine-rich interdomain region 1α-Plasmodium falciparum erythrocyte membrane protein 1 (CIDR1α-PfEMP1) is an antigenic protein that can bind to the endothelial protein ...
Rosita Dewi, Erma Sulistyaningsih, Irawan Fajar Kusuma, Sheilla Rachmania, Nafisah Hani Asyifah Rahma   +4 more
doaj   +1 more source