Results 91 to 100 of about 7,599,404 (323)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
SYNTHESIS OF CHITOSAN-FILM COMPOSITE Ti O2 USING SORBITOL AS PLASTICIZER
Alchemy, 2017 The synthesis of chitosan–TiO2 film composite using sorbitol as plasticizer has been conducted. This research aims to develop environmental friendly plastic material which is safe for health due to the use of biodegradable chitosan - TiO2 that can block ...
Imelda Fajriati +2 more
doaj +1 more source
Laplacian Center Vortices [PDF]
, 2000 I present a unified picture of center vortices and Abelian monopoles. Both appear as local gauge ambiguities in the Laplacian Center Gauge. This gauge is constructed for a general SU(N) theory.
de Forcrand, Ph., Pepe, M.
core +1 more source
The "Cameo Principle" and the Origin of Scale-Free Graphs in Social Networks
, 2003 We formulate a simple edge generation rule based on an inverse like mass action principle for random graphs over a structured vertex set. We show that under very weak assumptions on the structure generating distribution we obtain a scale free ...
Blanchard, Ph., Krueger, T.
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Scale invariant Volkov–Akulov supergravity
Physics Letters B, 2015 A scale invariant goldstino theory coupled to supergravity is obtained as a standard supergravity dual of a rigidly scale-invariant higher-curvature supergravity with a nilpotent chiral scalar curvature.
S. Ferrara, M. Porrati, A. Sagnotti
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Schweizerische Zeitschrift für BildungswissenschaftenHochschuldozierende beeinflussen massgeblich die Kompetenzentwicklung angehender Lehrpersonen und sollen sowohl berufspraktisch als auch wissenschaftlich qualifiziert sein.
Melanie Elderton +2 more
doaj +1 more source