Results 61 to 70 of about 531,900 (348)

Phage spanins: diversity, topological dynamics and gene convergence

BMC Bioinformatics, 2018
Background Spanins are phage lysis proteins required to disrupt the outer membrane. Phages employ either two-component spanins or unimolecular spanins in this final step of Gram-negative host lysis.
Rohit Kongari, Manoj Rajaure, Jesse Cahill, Eric Rasche, Eleni Mijalis, Joel Berry, Ry Young   +6 more
doaj   +1 more source

PHAST: A Fast Phage Search Tool

Nucleic Acids Res., 2011
PHAge Search Tool (PHAST) is a web server designed to rapidly and accurately identify, annotate and graphically display prophage sequences within bacterial genomes or plasmids.
You Zhou, Yongjie Liang, Karlene H. Lynch, J. Dennis, D. Wishart   +4 more
semanticscholar   +1 more source

Understanding Bacteriophage Tail Fiber Interaction with Host Surface Receptor: The Key “Blueprint” for Reprogramming Phage Host Range

International Journal of Molecular Sciences, 2022
Bacteriophages (phages), as natural antibacterial agents, are being rediscovered because of the growing threat of multi- and pan-drug-resistant bacterial pathogens globally. However, with an estimated 1031 phages on the planet, finding the right phage to
Jarin Taslem Mourosi, Ayobami I. Awe, Wenzheng Guo, Himanshu Batra, Harrish Ganesh, Xiaorong Wu, Jingen Zhu   +6 more
semanticscholar   +1 more source

Non-active antibiotic and bacteriophage synergism to successfully treat recurrent urinary tract infection caused by extensively drug-resistant Klebsiella pneumoniae

Emerging Microbes and Infections, 2020
We report a case of a 63-year-old female patient who developed a recurrent urinary tract infection (UTI) with extensively drug-resistant Klebsiella pneumoniae (ERKp).
Juan Bao, Nannan Wu, Yigang Zeng, Liguang Chen, Linlin Li, Lan Yang, Yiyuan Zhang, Mingquan Guo, Lisha Li, Jie Li, Demeng Tan, Mengjun Cheng, Jingmin Gu, Jinghong Qin, Jiazheng Liu, Shiru Li, Guangqiang Pan, Xin Jin, Bangxin Yao, Xiaokui Guo, Tongyu Zhu, Shuai Le   +21 more
doaj   +1 more source

Case Report: successful use of phage therapy in refractory MRSA chronic rhinosinusitis

International Journal of Infectious Diseases, 2022
We present a case of refractory methicillin-resistant Staphylococcus aureus that was successfully treated with a combination of antibiotics, systemic phage and intranasal phage therapy.
J. Martin Rodriguez, Bradford A Woodworth, Bri'Anna Horne, Joseph Fackler, Michael J. Brownstein   +4 more
doaj   +1 more source

Identification of Cohesive Ends and Genes Encoding the Terminase of Phage 16-3 [PDF]

, 2005
Cohesive ends of 16-3, a temperate phage of Rhizobium meliloti 41, have been identified as 10-base-long, 3′-protruding complementary G/C-rich sequences. terS and terL encode the two subunits of 16-3 terminase.
Buzas, Z., Csiszovszki, Z., Ganyu, A., Kern, A., Orosz, László, Papp, P. P., Ponyi, T.   +6 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Rapid de novo evolution of lysis genes in single-stranded RNA phages

Nature Communications, 2020
Leviviruses are phages with ssRNA genomes that encode a protein (Sgl) that induces host autolysis by interfering with bacterial cell wall synthesis. Identification of sgl genes is complicated by their small size and lack of sequence similarity.
Karthik R. Chamakura, Jennifer S. Tran, Chandler O’Leary, Hannah G. Lisciandro, Sophia F. Antillon, Kameron D. Garza, Elizabeth Tran, Lorna Min, Ry Young   +8 more
doaj   +1 more source

Structural Assembly of Qβ Virion and Its Diverse Forms of Virus-like Particles

Viruses, 2022
The coat proteins (CPs) of single-stranded RNA bacteriophages (ssRNA phages) directly assemble around the genomic RNA (gRNA) to form a near-icosahedral capsid with a single maturation protein (Mat) that binds the gRNA and interacts with the retractile ...
Jeng-Yih Chang, Karl V. Gorzelnik, Jirapat Thongchol, Junjie Zhang   +3 more
doaj   +1 more source

Effects of Noise on Ecological Invasion Processes: Bacteriophage-mediated Competition in Bacteria

, 2006
Pathogen-mediated competition, through which an invasive species carrying and transmitting a pathogen can be a superior competitor to a more vulnerable resident species, is one of the principle driving forces influencing biodiversity in nature.
A. J. McKane, A. J. McKane, C. W. Gardiner, D. T. Gillespie, E. Andjel, Eric Harvill, F. Thomas, G. David, J. D. Murray, J. Joo, J. V. Greenman, Jaewook Joo, K. Kuulasmaa, L. E. Reichl, M. B. Bonsall, M. Begon, M. E. J. Newman, M. G. Weinbauer, M. Liu, M. Ptashne, N. G. Kampen Van, N. Grassly, N.S. Goel, O. N. Bjornstad, P. A. Cotter, P. Hudson, P. Rohani, R. D. Holt, R. D. Holt, R. Durrett, R. Durrett, R. G. Bowers, R. Pastor-Satorras, Réka Albert, S. M. Faruque, T. M. Liggett, T. Park   +36 more
core   +1 more source