Results 71 to 80 of about 140,627 (227)
Frontiers in Microbiology, 2021 Antimicrobial resistance (AMR) is a major problem globally. The main bacterial organisms associated with urinary tract infection (UTI) associated sepsis are E. coli and Klebsiella along with Enterobacter species. These all have AMR strains known as ESBL (
Melissa E. K. Haines +16 more
doaj +1 more source
Metagenomic Analysis of Therapeutic PYO Phage Cocktails from 1997 to 2014 [PDF]
Viruses, 2017 Phage therapy has regained interest in recent years due to the alarming spread of antibiotic resistance. Whilst phage cocktails are commonly sold in pharmacies in countries such as Georgia and Russia, this is not the case in western countries due to western regulatory agencies requiring a thorough characterization of the drug.
Julia Villarroel +3 more
openaire +5 more sources
Advanced Science, EarlyView.Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao +36 more
wiley +1 more source
Nature CommunicationsBacteriophage therapy is a promising approach to address antimicrobial infections though questions remain regarding the impact of the immune response on clinical effectiveness.
Julia D. Berkson +12 more
doaj +1 more source
Viruses, 2023 Extensive and multiple drug resistance in P. aeruginosa combined with the formation of biofilms is responsible for its high persistence in nosocomial infections.
Medhavi Vashisth +8 more
doaj +1 more source
Journal of Molecular Biology, 2022 Phages, as well as phage-derived proteins, especially lysins and depolymerases, are intensively studied to become prospective alternatives or supportive antibacterials used alone or in combination. In the common phage therapy approach, the unwanted emergence of phage-resistant variants from the treated bacterial population can be postponed or reduced ...
Smug, Bogna +2 more
openaire +3 more sources
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Frontiers in MicrobiologyFood safety continues to be an important issue for consumer protection and public health globally. Chicken meat is considered a primary source of Salmonella and E. coli infections in humans. In recent years, phage-based biocontrol has attracted attention
Oleksandra Berhilevych +4 more
doaj +1 more source
Phage cocktail SalmoFREE® reduces Salmonella on a commercial broiler farm
Poultry Science, 2019 According to the World Health Organization, Salmonella is one of the most important zoonotic foodborne pathogens. Poultry products are thought to be the main source of Salmonella, which means that it is necessary to control Salmonella at the pre-harvest stage.
V Clavijo +7 more
openaire +2 more sources
A mechanism-based pathway toward administering highly active N-phage cocktails
Frontiers in Microbiology, 2023 Bacteriophage (phage) therapy is being explored as a possible response to the antimicrobial resistance public health emergency. Administering a mixture of different phage types as a cocktail is one proposed strategy for therapeutic applications, but the optimal method for formulating phage cocktails remains a major challenge.
Nicholas M. Smith +7 more
openaire +3 more sources