Results 81 to 90 of about 140,627 (227)

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Estimation of the In-Vitro Synergistic Effect of Vancomycin with Bacteriophage and its Endolysin on Iraqi Local Isolates of Enterococcus faecalis

مجلة بغداد للعلوم
Enterococcus faecalis is known to cause many serious infections with an upsurge in the development of antibiotic resistant strains, especially vancomycin.
Rand R. Hafidh, Zainab Oday Hamed, Abdullah A. Awni, Manal N. Jassas   +3 more
doaj   +1 more source

Phage Cocktail Development for Bacteriophage Therapy: Toward Improving Spectrum of Activity Breadth and Depth

Pharmaceuticals, 2021
Phage therapy is the use of bacterial viruses as antibacterial agents. A primary consideration for commercial development of phages for phage therapy is the number of different bacterial strains that are successfully targeted, as this defines the breadth
S. Abedon, Katarzyna Danis-Wlodarczyk, D. Wozniak   +2 more
semanticscholar   +1 more source

Omics Insights Into the Effects of Highbush Blueberry and Cranberry Crop Agroecosystems on Honey Bee Health and Physiology

PROTEOMICS, EarlyView.
ABSTRACT Honey bees (Apis mellifera) are vital pollinators in fruit‐producing agroecosystems like highbush blueberry (HBB) and cranberry (CRA). However, their health is threatened by multiple interacting stressors, including pesticides, pathogens, and nutritional changes.
Huan Zhong, Yuming Shi, Aleksandra Kozlova, Renata Moravcova, Jason C. Rogalski, Aidan Jamieson, Lance Lansing, Kyung‐Mee Moon, Xiaojing Yuan, Amanda S. Gregoris, Heather Higo, Julia Common, Ida M. Conflitti, Mateus Pepinelli, Lan Tran, Morgan Cunningham, Hosna Jabbari, Syed Abbas Bukhari, Sarah K. French, Rodrigo Ortega Polo, Shelley E. Hoover, Stephen F. Pernal, Pierre Giovenazzo, M. Marta Guarna, Amro Zayed, Leonard J. Foster   +25 more
wiley   +1 more source

Phage treatment significantly reduces Salmonella shedding in layer hens and Salmonella abundance on the surface of the eggs they produce

Poultry Science
Non-typhoidal Salmonella species cause 85% of human foodborne cases and infections caused by multidrug-resistant Salmonella strains are increasing. Therefore, alternative antimicrobials are needed, and phage therapy offers a promising tool to reduce the ...
Anisha M. Thanki, Natasha Whenham, Tom Dale, Mike R. Bedford, Helen V. Masey O’Neill, Martha R.J. Clokie   +5 more
doaj   +1 more source

PHAGE COCKTAILS AGAINST HIGHLY MULTI-DRUG RESISTANT ACINETOBACTER BAUMANII [PDF]

Iraqi Journal of Medical Sciences, 2018
Background:Phage therapy is a potential alternative treatment for infections caused by many bacterial species such as Acinetobacter baumannii (A. baumannii), a significant nosocomial pathogen, has evolved resistance to almost all conventional antimicrobial drugs in poor hygiene and conflicts areas like Iraq.
Hayder Jasim, Ahmad Abdul-Ameer
openaire   +2 more sources

Refining responsive antimicrobial nanomaterials from random peptide libraries via machine learning

Responsive Materials, EarlyView.
Machine learning refines random peptide mixtures into responsive antimicrobial cocktails, yielding enhanced antibacterial efficacy and improved in vivo therapeutic effects. Abstract Antimicrobial resistance has evolved into one of the most serious threats to global public health, yet generalizable routes for refining random peptide mixtures (RPMs) into
Lin Wang, Lexuan Shi, Bocheng Xu, Lutong Zhou, Tingjun Chen, Chen Yang, Mingliang Jin, Yizhen Wang   +7 more
wiley   +1 more source

A Review of Phage Therapy for Aquaculture Applications: Efficacy, Health Ramifications and Research Challenges

Fish and Fisheries, EarlyView.
Bacteriophage therapy is characterised by numerous advantages, facilitating its diverse aquaculture application and efficacy as an antibiotic alternative mitigating the spread of antimicrobial‐resistant pathogens. Contributing to the modern reappraisal of the aquaculture application of bacteriophage therapy, challenges impeding its widespread ...
Louise James, Tamsyn M. Uren Webster, Gethin Thomas, Mathias Middelboe, Sofia Consuegra   +4 more
wiley   +1 more source

A bacteriophage cocktail can efficiently reduce five important Salmonella serotypes both on chicken skin and stainless steel

Frontiers in Microbiology
Salmonella is one of the most important zoonotic pathogens and is mostly transmitted through food of animal origin. Application of bacteriophages is a promising tool to biocontrol Salmonella on both food and food contact surfaces.
Tamar Gvaladze, Hansjörg Lehnherr, Stefan Hertwig   +2 more
doaj   +1 more source

Directed in Vitro Evolution of Therapeutic Bacteriophages: The Appelmans Protocol

Viruses, 2019
The ‘Appelmans protocol’ is used by Eastern European researchers to generate therapeutic phages with novel lytic host ranges. Phage cocktails are iteratively grown on a suite of mostly refractory bacterial isolates until the evolved cocktail ...
Ben H. Burrowes, Ian J. Molineux, Joe A. Fralick   +2 more
doaj   +1 more source