Results 111 to 120 of about 73,738 (335)
Scientific Reports, 2017 Phage peptide display is a powerful technique for discovery of various target-specific ligands. However, target-unrelated peptides can often be obtained and cause ambiguous results.
Xu Qiang +10 more
semanticscholar +1 more source
, 2003 Bacteriophage display systems have been developed to allow the selection of a protein or peptide based on its ability to bind to a selected target molecule.
PALMER DB +3 more
core +1 more source
PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes
Advanced Science, EarlyView.A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li +10 more
wiley +1 more source
AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint
Advanced Science, EarlyView.AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz +4 more
wiley +1 more source
Phage display-derived human antibodies in clinical development and therapy
mAbs, 2016 Over the last 3 decades, monoclonal antibodies have become the most important class of therapeutic biologicals on the market. Development of therapeutic antibodies was accelerated by recombinant DNA technologies, which allowed the humanization of murine ...
A. Frenzel, T. Schirrmann, M. Hust
semanticscholar +1 more source
Development of phage display-derived targeted cancer therapy and net-work scaffold for 3D cancer cell culture [PDF]
, 2018 Precision medicine emphasizes the patient-specific formulation for treating diseases, especially cancer. For targeted cancer treatment, however, since the expression level of tumor receptors on each patient varies even for the same type of cancer, the ...
Qu, Xuewei
core
Cognate peptide-receptor ligand mapping by directed phage display [PDF]
, 2005 Background: A rapid phage display method for the elucidation of cognate peptide specific ligand for receptors is described. The approach may be readily integrated into the interface of genomic and proteomic studies to identify biologically relevant ...
Kang, A.S. +9 more
core +1 more source
Advanced Science, EarlyView.Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn +12 more
wiley +1 more source
Isolation of phage-antibodies against Eimeria species that infect chickens
Eimeria is one of the most economically important pathogens in poultry production. Diagnosis of infection has the potential to inform treatment and prevention strategies.
Owen, Jonathan P. +3 more
core +1 more source
Advanced Science, EarlyView.Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan +7 more
wiley +1 more source