Results 301 to 310 of about 121,778 (347)
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2017
ORFeome phage display allows the efficient functional screening of entire proteomes or even metaproteomes to identify immunogenic proteins. For this purpose, randomly fragmented, whole genomes or metagenomes are cloned into a phage-display vector allowing positive selection for open reading frames (ORF) to improve the library quality.
Jonas, Zantow +3 more
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ORFeome phage display allows the efficient functional screening of entire proteomes or even metaproteomes to identify immunogenic proteins. For this purpose, randomly fragmented, whole genomes or metagenomes are cloned into a phage-display vector allowing positive selection for open reading frames (ORF) to improve the library quality.
Jonas, Zantow +3 more
openaire +2 more sources
2008
Molecular imaging is at the forefront in the advancement of in-vivo diagnosis and monitoring of cancer. New peptide-based molecular probes to facilitate cancer detection are rapidly evolving. Peptide-based molecular probes that target apoptosis, angiogenesis, cell signaling and cell adhesion events are in place. Bacteriophage (phage) display technology,
Jessica, Newton, Susan L, Deutscher
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Molecular imaging is at the forefront in the advancement of in-vivo diagnosis and monitoring of cancer. New peptide-based molecular probes to facilitate cancer detection are rapidly evolving. Peptide-based molecular probes that target apoptosis, angiogenesis, cell signaling and cell adhesion events are in place. Bacteriophage (phage) display technology,
Jessica, Newton, Susan L, Deutscher
openaire +2 more sources
Phages as delivery vehicles and phage display
2023Bacteriophages (Phages in short) were introduced as the natural enemy of bacteria that may act as alternatives to antibiotics to overcome the challenge of antibiotic resistance. However, in the recent history of science, phages have been employed in different molecular tools and used in numerous therapeutic and diagnostic approaches.
Salsabil, Makky +4 more
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2017
Antibody phage display has become an indispensable tool for the discovery and optimization of target-specific monoclonal antibodies suitable for demanding applications including therapeutic reagents. The in vitro nature of the technology enables the rapid and efficient identification of specific binders, as well as greater control over selection ...
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Antibody phage display has become an indispensable tool for the discovery and optimization of target-specific monoclonal antibodies suitable for demanding applications including therapeutic reagents. The in vitro nature of the technology enables the rapid and efficient identification of specific binders, as well as greater control over selection ...
openaire +2 more sources
Combinatorial Chemistry & High Throughput Screening, 2012
Shotgun phage display cloning is a useful tool for studying interactions between bacterial and host proteins. Libraries are constructed by cloning randomly fragmented prokaryotic DNA into phage mid-vectors. Theoretically, these libraries will consist of phages that together display all proteins encoded by the bacterial genome.
K, Jacobsson, L, Frykberg
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Shotgun phage display cloning is a useful tool for studying interactions between bacterial and host proteins. Libraries are constructed by cloning randomly fragmented prokaryotic DNA into phage mid-vectors. Theoretically, these libraries will consist of phages that together display all proteins encoded by the bacterial genome.
K, Jacobsson, L, Frykberg
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Antibody discovery: phage display
Current Opinion in Biotechnology, 2002Phage display has proven to be a robust and convenient technology for the selection of high-quality human antibodies from diverse libraries. Besides enabling the identification of antibodies in a fast, high-throughput mode, which allows comprehensive protein expression analyses, phage display has been used to identify a fully human therapeutic antibody
Titus, Kretzschmar, Thomas, von Rüden
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Phage Display of Antibody Fragments
Current Protein and Peptide Science, 2000In recent years, phage display of peptides and proteins has become a very popular method in oncology, immunology, protein engineering and ligand-receptor studies among others. Antibody fragments, as Fabs or single chain Fv, have been among the first proteins to be displayed on the surface of a filamentous bacteriophage with a procedure initially ...
PINI, ALESSANDRO, BRACCI, LUISA
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Fibrinolysis, 1994
Filamentous phage display of peptides, proteins, and protein fragments is a powerful method for the selection of functional clones from vast libraries. Over the past few years this approach has been utilized to probe the binding sites of receptors and enzymes and to make the hybridoma approach to monoclonal antibodies obsolete.
S.M. Barbas, C.F. Barbas
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Filamentous phage display of peptides, proteins, and protein fragments is a powerful method for the selection of functional clones from vast libraries. Over the past few years this approach has been utilized to probe the binding sites of receptors and enzymes and to make the hybridoma approach to monoclonal antibodies obsolete.
S.M. Barbas, C.F. Barbas
openaire +1 more source
2016
Chemokines are small chemoattractant proteins involved in the recruitment of leukocytes to the site of inflammation. Due to their prominent role in the inflammatory process, chemokine inhibitors have been developed by parasites to remain undetected not only by the host immune system but also by various laboratories to develop anti-inflammatory ...
Pauline, Bonvin +3 more
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Chemokines are small chemoattractant proteins involved in the recruitment of leukocytes to the site of inflammation. Due to their prominent role in the inflammatory process, chemokine inhibitors have been developed by parasites to remain undetected not only by the host immune system but also by various laboratories to develop anti-inflammatory ...
Pauline, Bonvin +3 more
openaire +2 more sources