A proposed integrated approach for the preclinical evaluation of phage therapy in Pseudomonas infections [PDF]
, 2016 Bacteriophage therapy is currently resurging as a potential complement/alternative to antibiotic treatment. However, preclinical evaluation lacks streamlined approaches.
Arabski, Michal +13 more
core +2 more sources
Phage Cocktails and the Future of Phage Therapy
Future Microbiology, 2013 Viruses of bacteria, known as bacteriophages or phages, were discovered nearly 100 years ago. Their potential as antibacterial agents was appreciated almost immediately, with the first 'phage therapy' trials predating Fleming's discovery of penicillin by approximately a decade.
Stephen T. Abedon +3 more
openaire +3 more sources
Low Immunogenicity of Intravesical Phage Therapy for Urogenitary Tract Infections
Antibiotics, 2021 Patients with chronic urinary and urogenital multidrug resistant bacterial infections received phage therapy (PT) using intravesical or intravesical and intravaginal phage administration.
Sławomir Letkiewicz +5 more
doaj +1 more source
Progress and Pitfalls of Bacteriophage Therapy in Critical Care: A Concise Definitive Review. [PDF]
, 2021 Objective Bacterial infections caused by antibiotic-resistant pathogens are a major problem for patients requiring critical care. An approach to combat resistance is the use of bacterial viruses known as "phage therapy." This review provides a brief ...
Cameron, David R. +3 more
core +1 more source
What are the limitations on the wider therapeutic use of phage? [PDF]
, 2013 Bacterial resistance to antibiotics poses a serious health threat. Since research into new antibiotics is not progressing at the same rate as the development of bacterial resistance, widespread calls for alternatives to antibiotics have been made.
Henein, Alexandra
core +1 more source
The Safety and Efficacy of Phage Therapy: A Systematic Review of Clinical and Safety Trials
Antibiotics, 2022 Trials of phage therapy have not consistently reported efficacy. This contrasts with promising efficacy rates from a sizeable and compelling body of observational literature.
H. Stacey +2 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 Bacteriolytic enzymes are promising antibacterial agents, but they can cause a typical immune response in vivo. In this study, we used a targeted modification method for two antibacterial endolysins, Pal and Cpl-1. We identified the key immunogenic amino
Marek Adam Harhala +14 more
doaj +1 more source
Limitations of Phage Therapy and Corresponding Optimization Strategies: A Review
Molecules, 2022 Bacterial infectious diseases cause serious harm to human health. At present, antibiotics are the main drugs used in the treatment of bacterial infectious diseases, but the abuse of antibiotics has led to the rapid increase in drug-resistant bacteria and
Jiaxi Lin, Fangyuan Du, M. Long, Peng Li
semanticscholar +1 more source
How to Train Your Phage: The Recent Efforts in Phage Training
Biologics, 2021 Control of pathogenic bacteria by deliberate application of predatory phages has potential as a powerful therapy against antibiotic-resistant bacteria.
Abdallah S. Abdelsattar +6 more
doaj +1 more source
Isolation, characterisation and experimental evolution of phage that infect the horse chestnut tree pathogen, Pseudomonas syringae pv. aesculi [PDF]
, 2020 Bleeding canker of horse chestnut trees is a bacterial disease, caused by the bacterium Pseudomonas syringae pv. aesculi, estimated to be present in ~ 50% of UK horse chestnut trees.
Jackson, Robert W. +4 more
core +3 more sources