Results 61 to 70 of about 4,551,719 (377)
Frontiers in Immunology, 2023 Bacteriolytic enzymes are promising antibacterial agents, but they can cause a typical immune response in vivo. In this study, we used a targeted modification method for two antibacterial endolysins, Pal and Cpl-1. We identified the key immunogenic amino
Marek Adam Harhala +14 more
doaj +1 more source
How to Train Your Phage: The Recent Efforts in Phage Training
Biologics, 2021 Control of pathogenic bacteria by deliberate application of predatory phages has potential as a powerful therapy against antibiotic-resistant bacteria.
Abdallah S. Abdelsattar +6 more
doaj +1 more source
Does Phage Therapy Need a Pan-Phage? [PDF]
PathogensThe emergence of multidrug-resistant bacteria is undoubtedly one of the most serious global health threats. One response to this threat that has been gaining momentum over the past decade is ‘phage therapy’. According to this, lytic bacteriophages are used for the treatment of bacterial infections, either alone or in combination with antimicrobial ...
Bozidis P +3 more
europepmc +4 more sources
What are the limitations on the wider therapeutic use of phage? [PDF]
, 2013 Bacterial resistance to antibiotics poses a serious health threat. Since research into new antibiotics is not progressing at the same rate as the development of bacterial resistance, widespread calls for alternatives to antibiotics have been made.
Henein, Alexandra
core +1 more source
Isolation, characterisation and experimental evolution of phage that infect the horse chestnut tree pathogen, Pseudomonas syringae pv. aesculi [PDF]
, 2020 Bleeding canker of horse chestnut trees is a bacterial disease, caused by the bacterium Pseudomonas syringae pv. aesculi, estimated to be present in ~ 50% of UK horse chestnut trees.
Jackson, Robert W. +4 more
core +3 more sources
The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies
Viruses, 2021 Increasing rates of infection by antibiotic resistant bacteria have led to a resurgence of interest in bacteriophage (phage) therapy. Several phage therapy studies in animals and humans have been completed over the last two decades.
Dan Liu +9 more
semanticscholar +1 more source
Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates. [PDF]
, 2012 UnlabelledInvestigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial ...
Bowman, Charles +13 more
core +2 more sources
Reassessment of Historical Clinical Trials Supports the Effectiveness of Phage Therapy
Clinical Microbiology Reviews, 2022 Phage therapy has become a hot topic in medical research due to the increasing prevalence of antibiotic-resistant bacteria strains. In the treatment of bacterial infections, bacteriophages have several advantages over antibiotics, including strain ...
L. Marongiu +4 more
semanticscholar +1 more source
Phage Therapy in Gastrointestinal Diseases
Microorganisms, 2020 Gastrointestinal tract microbiota plays a key role in the regulation of the pathogenesis of several gastrointestinal diseases. In particular, the viral fraction, composed essentially of bacteriophages, influences homeostasis by exerting a selective pressure on the bacterial communities living in the tract.
Beatriz Gutiérrez, Pilar Domingo-Calap
openaire +3 more sources
Microorganisms, 2022 Escherichia coli (E. coli) is one of the most common pathogenic bacteria worldwide. Avian pathogenic E. coli (APEC) causes severe systemic disease in poultry (Colibacillosis), and accordingly, has an extreme risk to the poultry industry and public health
Fatma Abdelrahman +6 more
doaj +1 more source