Results 31 to 40 of about 435,809 (335)

Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome

Journal of Neuroscience, 2020
During adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. Here, we propose that phagocytosis is not merely passive corpse removal but
Irune Díaz-Aparicio, Iñaki Paris, Virginia Sierra-Torre, Ainhoa Plaza-Zabala, Noelia Rodriguez-Iglesias, Mar Márquez-Ropero, S. Beccari, Paloma Huguet, Oihane Abiega, Elena Alberdi, C. Matute, Irantzu Bernales, A. Schulz, Lilla Otrokocsi, B. Sperlágh, Kaisa E Happonen, G. Lemke, M. Maletić-Savatić, J. Valero, A. Sierra   +19 more
semanticscholar   +1 more source

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin

Journal of Neuroinflammation, 2012
Background Intact myelin, which normally surrounds axons, breaks down in Wallerian degeneration following axonal injury and during neurodegenerative diseases such as multiple sclerosis.
Hadas Smadar, Spira Maya, Hanisch Uwe-Karsten, Reichert Fanny, Rotshenker Shlomo   +4 more
doaj   +1 more source

Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]

, 2019
Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong, Lal, Bachchu, Laterra, John, Lee, Richard S, Li, Jian Jian, Liu, Senquan, Lopez-Bertoni, Hernando, Ma, Ding, Wang, Shuyan, Wei, Shuang, Wilson, Mary Ann, Xia, Shuli, Ying, Mingyao, Zhan, Daqian, Zhang, Hao   +14 more
core   +2 more sources

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

Frontiers in Immunology, 2020
Efficient inflammation resolution is important not only for the termination of the inflammatory response but also for the restoration of tissue integrity. An integral process to resolution of inflammation is the phagocytosis of dying cells by macrophages,
I. Kourtzelis, G. Hajishengallis, T. Chavakis   +2 more
semanticscholar   +1 more source

Phagocytic receptors activate and immune inhibitory receptor SIRPalpha inhibits phagocytosis through paxillin and cofilin

Frontiers in Cellular Neuroscience, 2014
The innate-immune function of phagocytosis of apoptotic cells, tissue-debris, pathogens and cancer cells is essential for homeostasis, tissue repair, fighting infection and combating malignancy.
Miri eGitik, Rachel eKleinhaus, Smadar eHadas, Fanny eReichert, Shlomo eRotshenker, Shlomo eRotshenker   +5 more
doaj   +1 more source

SIRT1-induced deacetylation of Akt expedites platelet phagocytosis and delays HEMEC aging

Molecular Therapy: Nucleic Acids, 2021
Maintaining the health of the endothelium is of critical importance to prevention against cell aging. The current study was performed to clarify the role of sirtuin1 (SIRT1) in platelet phagocytosis in cell aging and identified its downstream molecular ...
Yong Lan, Min Dong, Yongjun Li, Yongpeng Diao, Zuoguang Chen, Yangfang Li   +5 more
doaj   +1 more source

Target shape dependence in a simple model of receptor-mediated endocytosis and phagocytosis [PDF]

, 2016
Phagocytosis and receptor-mediated endocytosis are vitally important particle uptake mechanisms in many cell types, ranging from single-cell organisms to immune cells.
Endres, Robert G., Richards, David M.
core   +2 more sources

RNA interference in J774 macrophages reveals a role for coronin 1 in mycobacterial trafficking but not in actin-dependent processes [PDF]

, 2008
Macrophages are crucial for innate immunity, apoptosis, and tissue remodeling, processes that rely on the capacity of macrophages to internalize and process cargo through phagocytosis.
Rajesh Jayachandran, John Gatfield, Jan Massner, Imke Albrecht, Bettina Zanolari, Jean Pieters, Sandra Schmid, Aderem A., Allen L. A., Araki N., Brummelkamp T. R., David V., de Hostos E. L., de Hostos E. L., de Hostos E. L., Ferrari G., Ferrari G., Foger N., Gatfield J., Gerisch G., Goode B. L., Grogan A., Guerin I., Heil-Chapdelaine R. A., Humphries C. L., Itoh S., Jayachandran R., Johannes L., Maniak M., Nal B., Nguyen L., Okumura M., Pantaloni D., Parente J. A., Pieters J., Rybakin V., Scherr N., Schuller S., Smith T. F., Steinman R. M., Suzuki K., Tailleux L., Tulp A., Vieira O. V., Walburger A., Zheng P. Y.   +45 more
core   +1 more source

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity

Nature Communications, 2020
Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti-phagocytosis molecule CD47.
Christina A. von Roemeling, Yifan Wang, Yaqing Qie, Hengfeng Yuan, Hai Zhao, Xiujie Liu, Zhaogang Yang, Mingming Yang, W. Deng, K. A. Bruno, Charles K. F. Chan, Andrew S. Lee, S. Rosenfeld, Kyuson Yun, Aaron J. Johnson, D. Mitchell, Wen Jiang, Betty Y. S. Kim   +17 more
semanticscholar   +1 more source

The Phagocytic Code Regulating Phagocytosis of Mammalian Cells

Frontiers in Immunology, 2021
Mammalian phagocytes can phagocytose (i.e. eat) other mammalian cells in the body if they display certain signals, and this phagocytosis plays fundamental roles in development, cell turnover, tissue homeostasis and disease prevention.
Thomas O. J. Cockram, Jacob M. Dundee, Alma S. Popescu, Guy C. Brown   +3 more
semanticscholar   +1 more source