Results 31 to 40 of about 442,934 (391)
Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome
Journal of Neuroscience, 2020 During adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. Here, we propose that phagocytosis is not merely passive corpse removal but
Irune Díaz-Aparicio +19 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2014 The innate-immune function of phagocytosis of apoptotic cells, tissue-debris, pathogens and cancer cells is essential for homeostasis, tissue repair, fighting infection and combating malignancy.
Miri eGitik +5 more
doaj +1 more source
The Phagocytic Code Regulating Phagocytosis of Mammalian Cells
Frontiers in Immunology, 2021 Mammalian phagocytes can phagocytose (i.e. eat) other mammalian cells in the body if they display certain signals, and this phagocytosis plays fundamental roles in development, cell turnover, tissue homeostasis and disease prevention.
Thomas O. J. Cockram +3 more
semanticscholar +1 more source
Studying Membrane Biogenesis with a Luciferase-Based Reporter Gene Assay [PDF]
, 2008 To study the coordination of different lipid synthesis pathways during membrane biogenesis it is useful to work with an experimental system where membrane biogenesis occurs rapidly and in an inducible manner.
Nohturfft, A, Zhang, S
core +2 more sources
Phagocytosis of Apoptotic Cells in Resolution of Inflammation
Frontiers in Immunology, 2020 Efficient inflammation resolution is important not only for the termination of the inflammatory response but also for the restoration of tissue integrity. An integral process to resolution of inflammation is the phagocytosis of dying cells by macrophages,
I. Kourtzelis +2 more
semanticscholar +1 more source
Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]
, 2019 Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong +14 more
core +2 more sources
Nature Communications, 2020 Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti-phagocytosis molecule CD47.
Christina A. von Roemeling +17 more
semanticscholar +1 more source
The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape [PDF]
, 2010 Phagocytosis is the fundamental cellular process by which eukaryotic cells bind and engulf particles by their cell membrane. Particle engulfment involves particle recognition by cell-surface receptors, signaling and remodeling of the actin cytoskeleton ...
Dart, Anna E. +3 more
core +4 more sources
Identification of Drosophila gene products required for phagocytosis of Candida albicans.
PLoS Biology, 2006 Phagocytosis is a highly conserved aspect of innate immunity. We used Drosophila melanogaster S2 cells as a model system to study the phagocytosis of Candida albicans, the major fungal pathogen of humans, by screening an RNAi library representing 7,216 ...
Shannon L Stroschein-Stevenson +3 more
doaj +2 more sources
CD22 blockade restores homeostatic microglial phagocytosis in aging brains
Nature, 2019 Microglia maintain homeostasis in the central nervous system through phagocytic clearance of protein aggregates and cellular debris. This function deteriorates during ageing and neurodegenerative disease, concomitant with cognitive decline.
John V. Pluvinage +17 more
semanticscholar +1 more source