The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape [PDF]
, 2010 Phagocytosis is the fundamental cellular process by which eukaryotic cells bind and engulf particles by their cell membrane. Particle engulfment involves particle recognition by cell-surface receptors, signaling and remodeling of the actin cytoskeleton ...
Dart, Anna E. +3 more
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Identification of Drosophila gene products required for phagocytosis of Candida albicans.
PLoS Biology, 2006 Phagocytosis is a highly conserved aspect of innate immunity. We used Drosophila melanogaster S2 cells as a model system to study the phagocytosis of Candida albicans, the major fungal pathogen of humans, by screening an RNAi library representing 7,216 ...
Shannon L Stroschein-Stevenson +3 more
doaj +2 more sources
Ibrutinib impairs the phagocytosis of rituximab-coated leukemic cells from chronic lymphocytic leukemia patients by human macrophages [PDF]
, 2015 We have read with great interest the recent article of Kohrt, H.E. et al1 showing that Ibrutinib prevented NK cell mediated cytotoxicity of antibody-coated CLL cells in vitro.
Almejún, María Belén +8 more
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The Entamoeba histolytica, Arp2/3 Complex Is Recruited to Phagocytic Cups through an Atypical Kinase EhAK1. [PDF]
PLoS Pathogens, 2015 The parasite Entamoeba histolytica is the etiological agent of amoebiasis and phagocytosis plays a key role in virulence of this organism. Signaling pathways involved in activation of cytoskeletal dynamics required for phagocytosis remain to be ...
Mrigya Babuta +3 more
doaj +1 more source
Novel insights into host-fungal pathogen interactions derived from live-cell imaging [PDF]
, 2015 Acknowledgments The authors acknowledge funding from the Wellcome Trust (080088, 086827, 075470 and 099215) including a Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377 and FP7-2007–2013 grant agreement HEALTH-F2-2010 ...
A Casadevall +77 more
core +1 more source
The Roles of Membrane Rafts in CD32A-Mediated Phagocytosis [PDF]
, 2007 Membrane rafts are highly dynamic heterogeneous sterol- and sphingolipid-rich micro-domains on cell surfaces. They are generally believed to provide residency for cell surface molecules (e.g., adhesion and signaling molecules) and scaffolding to ...
Cheng Zhu +2 more
core +2 more sources
High-throughput quantification of early stages of phagocytosis
BioTechniques, 2013 Phagocytosis—the engulfment of cells and foreign bodies—is an important cellular process in innate immunity, development, and disease. Quantification of various stages of phagocytosis, especially in a rapid screening fashion, is an invaluable tool for ...
Jeremy Changyu Yeo +3 more
doaj +1 more source
Phagocytosis: Our Current Understanding of a Universal Biological Process
Frontiers in Immunology, 2020 Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm in diameter, including microorganisms, foreign substances, and apoptotic cells.
Eileen Uribe-Querol, Carlos Rosales
doaj +1 more source
Efficient measurement of opsonising antibodies to Plasmodium falciparum merozoites. [PDF]
PLoS ONE, 2012 Antibodies targeting merozoites are important in protection from malaria. Therefore, merozoite surface proteins are attractive vaccine candidates. There is a need for robust functional assays to investigate mechanisms of acquired immunity and vaccine ...
Danika L Hill +6 more
doaj +1 more source
Vomocytosis: Too Much Booze, Base, or Calcium? [PDF]
, 2019 Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of mechanisms, and typically break down internalized cargo into small macromolecules.
Aaron +98 more
core +2 more sources