Results 31 to 40 of about 396,432 (395)

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

Frontiers in Immunology, 2020
Efficient inflammation resolution is important not only for the termination of the inflammatory response but also for the restoration of tissue integrity. An integral process to resolution of inflammation is the phagocytosis of dying cells by macrophages,
I. Kourtzelis, G. Hajishengallis, T. Chavakis   +2 more
semanticscholar   +1 more source

Phagocytosis in Teleosts. Implications of the New Cells Involved

Biology, 2015
Phagocytosis is the process by which cells engulf some solid particles to form internal vesicles known as phagosomes. Phagocytosis is in fact a specific form of endocytosis involving the vesicular interiorization of particles. Phagocytosis is essentially
María Ángeles Esteban, Alberto Cuesta, Elena Chaves-Pozo, José Meseguer   +3 more
doaj   +1 more source

PhagoStat a scalable and interpretable end to end framework for efficient quantification of cell phagocytosis in neurodegenerative disease studies [PDF]

, 2023
Quantifying the phagocytosis of dynamic, unstained cells is essential for evaluating neurodegenerative diseases. However, measuring rapid cell interactions and distinguishing cells from background make this task very challenging when processing time-lapse phase-contrast video microscopy.
arxiv   +1 more source

PD-1 expression by tumor-associated macrophages inhibits phagocytosis and tumor immunity

Nature, 2017
Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor that is upregulated on activated T cells for the induction of immune tolerance.
S. Gordon, R. Maute, Ben W. Dulken, G. Hutter, B. George, Melissa N. Mccracken, Rohit Gupta, Jonathan M. Tsai, Rahul Sinha, Daniel M. Corey, A. Ring, A. Connolly, I. Weissman   +12 more
semanticscholar   +1 more source

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin

Journal of Neuroinflammation, 2012
Background Intact myelin, which normally surrounds axons, breaks down in Wallerian degeneration following axonal injury and during neurodegenerative diseases such as multiple sclerosis.
Hadas Smadar, Spira Maya, Hanisch Uwe-Karsten, Reichert Fanny, Rotshenker Shlomo   +4 more
doaj   +1 more source

Phagocytic receptors activate and immune inhibitory receptor SIRPalpha inhibits phagocytosis through paxillin and cofilin

Frontiers in Cellular Neuroscience, 2014
The innate-immune function of phagocytosis of apoptotic cells, tissue-debris, pathogens and cancer cells is essential for homeostasis, tissue repair, fighting infection and combating malignancy.
Miri eGitik, Rachel eKleinhaus, Smadar eHadas, Fanny eReichert, Shlomo eRotshenker, Shlomo eRotshenker   +5 more
doaj   +1 more source

Clearance of apoptotic cells by macrophages induces regulatory phenotype and involves stimulation of cd36 and platelet-activating factor receptor [PDF]

, 2013
Phagocytosis of apoptotic cells (efferocytosis) induces macrophage differentiation towards a regulatory phenotype (IL-10high/IL-12p40low). CD36 is involved in the recognition of apoptotic cells (AC), and we have shown that the platelet-activating factor ...
Ferracini, M., Jancar, S., Pecenin, M., Rios, F.J.O.   +3 more
core   +2 more sources

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity

Nature Communications, 2020
Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti-phagocytosis molecule CD47.
Christina A. von Roemeling, Yifan Wang, Yaqing Qie, Hengfeng Yuan, Hai Zhao, Xiujie Liu, Zhaogang Yang, Mingming Yang, W. Deng, K. A. Bruno, Charles K. F. Chan, Andrew S. Lee, S. Rosenfeld, Kyuson Yun, Aaron J. Johnson, D. Mitchell, Wen Jiang, Betty Y. S. Kim   +17 more
semanticscholar   +1 more source

Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]

, 2019
Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong, Lal, Bachchu, Laterra, John, Lee, Richard S, Li, Jian Jian, Liu, Senquan, Lopez-Bertoni, Hernando, Ma, Ding, Wang, Shuyan, Wei, Shuang, Wilson, Mary Ann, Xia, Shuli, Ying, Mingyao, Zhan, Daqian, Zhang, Hao   +14 more
core   +2 more sources

The mechanism of phagocytosis: two stages of engulfment [PDF]

Biophysical Journal 107:1542-1553 (2014), 2014
Despite being of vital importance to the immune system, the mechanism by which cells engulf relatively large solid particles during phagocytosis is still poorly understood. From movies of neutrophil phagocytosis of polystyrene beads, we measure the fractional engulfment as a function of time and demonstrate that phagocytosis occurs in two distinct ...
arxiv   +1 more source