Results 31 to 40 of about 273,745 (349)
Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome
Journal of Neuroscience, 2020 During adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. Here, we propose that phagocytosis is not merely passive corpse removal but
Irune Díaz-Aparicio +19 more
semanticscholar +1 more source
Phagocytosis in Teleosts. Implications of the New Cells Involved
Biology, 2015 Phagocytosis is the process by which cells engulf some solid particles to form internal vesicles known as phagosomes. Phagocytosis is in fact a specific form of endocytosis involving the vesicular interiorization of particles. Phagocytosis is essentially
María Ángeles Esteban +3 more
doaj +1 more source
SIRT1-induced deacetylation of Akt expedites platelet phagocytosis and delays HEMEC aging
Molecular Therapy: Nucleic Acids, 2021 Maintaining the health of the endothelium is of critical importance to prevention against cell aging. The current study was performed to clarify the role of sirtuin1 (SIRT1) in platelet phagocytosis in cell aging and identified its downstream molecular ...
Yong Lan +5 more
doaj +1 more source
Phagocytosis: An Immunobiologic Process. [PDF]
Immunity, 2016 It has been a century since the death of Élie Metchnikoff, who championed the role of phagocytosis in cellular immunity. Whereas others had observed the uptake of particles by cells from simple to complex organisms, he grasped its significance in the host response to injury and infection and established a firm basis for our understanding of ...
S. Gordon
semanticscholar +5 more sources
The Phagocytic Code Regulating Phagocytosis of Mammalian Cells
Frontiers in Immunology, 2021 Mammalian phagocytes can phagocytose (i.e. eat) other mammalian cells in the body if they display certain signals, and this phagocytosis plays fundamental roles in development, cell turnover, tissue homeostasis and disease prevention.
Thomas O. J. Cockram +3 more
semanticscholar +1 more source
Immunity, 2005 Phagocytosis requires receptor-mediated recognition of particles, usually in the guise of infectious agents and apoptotic cells. Phagosomes fuse with lysosomes to generate phagolysosomes, which play a key role in enzymatic digestion of the internalized contents into component parts.
Lynda M. Stuart +2 more
openaire +3 more sources
Journal of Neuroinflammation, 2012 Background Intact myelin, which normally surrounds axons, breaks down in Wallerian degeneration following axonal injury and during neurodegenerative diseases such as multiple sclerosis.
Hadas Smadar +4 more
doaj +1 more source
PD-1 expression by tumor-associated macrophages inhibits phagocytosis and tumor immunity
Nature, 2017 Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor that is upregulated on activated T cells for the induction of immune tolerance.
S. Gordon +12 more
semanticscholar +1 more source
Phagocytosis of Apoptotic Cells in Resolution of Inflammation
Frontiers in Immunology, 2020 Efficient inflammation resolution is important not only for the termination of the inflammatory response but also for the restoration of tissue integrity. An integral process to resolution of inflammation is the phagocytosis of dying cells by macrophages,
I. Kourtzelis +2 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2014 The innate-immune function of phagocytosis of apoptotic cells, tissue-debris, pathogens and cancer cells is essential for homeostasis, tissue repair, fighting infection and combating malignancy.
Miri eGitik +5 more
doaj +1 more source