Results 171 to 180 of about 32,198 (216)
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Immunological Reviews, 2023
SummaryPhagocytosis is a fundamental immunobiological process responsible for the removal of harmful particulates. While the number of phagocytic events achieved by a single phagocyte can be remarkable, exceeding hundreds per day, the same phagocytic cells are relatively long‐lived.
Sivakami Mylvaganam, Spencer A. Freeman
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SummaryPhagocytosis is a fundamental immunobiological process responsible for the removal of harmful particulates. While the number of phagocytic events achieved by a single phagocyte can be remarkable, exceeding hundreds per day, the same phagocytic cells are relatively long‐lived.
Sivakami Mylvaganam, Spencer A. Freeman
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The NADPH Oxidase and the Phagosome
2020The key purpose of phagocytosis is the destruction of pathogenic microorganisms. The phagocytes exert a wide array of killing mechanisms that allow mastering the vast majority of pathogens. One of these mechanisms consists in the production of reactive oxygen species inside the phagosome by a specific enzyme, the phagocyte NADPH oxidase. This enzyme is
Hana, Valenta +3 more
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Measurement of phagosome-lysosome fusion and phagosomal pH
1994Publisher Summary Phagosome–lysosome fusion has been assessed by several different methods. Most of these strategies involve either the identification of endogenous lysosomal markers in organelles containing ingested organisms or the colocalization of the phagocytosed organism with an exogenous marker endocytosed by the cell and sequestered within ...
T H, Steinberg, J A, Swanson
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Chloroquine and the fungal phagosome
Current Opinion in Microbiology, 2000The antimalarial drug chloroquine accumulates inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C.
S M, Weber, S M, Levitz, T S, Harrison
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Intracellular Transformation of Phagosomes
Biology Bulletin, 2004The transformation of nascent phagosomes into forms capable of interacting with antimicrobial organelles of phagocytes, peroxisomes, depends on certain interactions between phagosomes and other vacuolar organelles. Phagosomes repeatedly interact with early and late endosomes through temporary contacts, which allows them to gain and lose complex sets of
P G, But +3 more
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2008
Autophagy and phagocytosis are evolutionarily ancient processes functioning in capture and digestion of material found in the cellular interior and exterior, respectively. In their most primordial form, both processes are involved in cellular metabolism and feeding, supplying cells with externally obtained particulate nutrients or using portions of ...
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Autophagy and phagocytosis are evolutionarily ancient processes functioning in capture and digestion of material found in the cellular interior and exterior, respectively. In their most primordial form, both processes are involved in cellular metabolism and feeding, supplying cells with externally obtained particulate nutrients or using portions of ...
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Rab GTPases Regulating Phagosome Maturation Are Differentially Recruited to Mycobacterial Phagosomes [PDF]
Traffic, 2011 Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that can replicate within infected macrophages. The ability of M. tb to arrest phagosome maturation is believed to facilitate its intracellular multiplication. Rab GTPases regulate membrane trafficking, but details of how Rab GTPases regulate phagosome maturation and how M ...
Shintaro Seto +2 more
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Phagosome dynamics and function
BioEssays, 2000Phagocytosis of microorganisms and other particles is mediated most efficiently by receptors such as Fc-receptors (FcR) and complement-receptors (C3R). Interaction between these receptors and ligands on the particle results in signal transduction events that lead to actin polymerisation and phagosome formation. The phagosome then undergoes a maturation
T E, Tjelle, T, Lovdal, T, Berg
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Protoplasma, 1967
Lysosomes were first described as cell particles or granules. I am now inclined to call them vacuoles, even when they appear as compact bodies, in order to emphasize the essentially extracellular character of their contents. Together with the phagosomes, they form what is conveniently referred to as the vacuolarapparatus [1], an intracellular digestive
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Lysosomes were first described as cell particles or granules. I am now inclined to call them vacuoles, even when they appear as compact bodies, in order to emphasize the essentially extracellular character of their contents. Together with the phagosomes, they form what is conveniently referred to as the vacuolarapparatus [1], an intracellular digestive
openaire +3 more sources