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Vacuolar-ATPase inhibitors are antimicrobial agents active against intracellular mycobacteria. [PDF]
Antimicrob Agents ChemotherRankine-Wilson L +9 more
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Phagosome Maturation in Macrophages is Enhanced by p38α MAPK Signaling
Shah M +4 more
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Immunological Reviews, 2023
SummaryPhagocytosis is a fundamental immunobiological process responsible for the removal of harmful particulates. While the number of phagocytic events achieved by a single phagocyte can be remarkable, exceeding hundreds per day, the same phagocytic cells are relatively long‐lived.
Sivakami Mylvaganam, Spencer A. Freeman
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SummaryPhagocytosis is a fundamental immunobiological process responsible for the removal of harmful particulates. While the number of phagocytic events achieved by a single phagocyte can be remarkable, exceeding hundreds per day, the same phagocytic cells are relatively long‐lived.
Sivakami Mylvaganam, Spencer A. Freeman
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Patterns, Receptors, and Signals: Regulation of Phagosome Maturation [PDF]
Trends in Immunology, 2017 Recognition of microbial pathogens and dead cells and their phagocytic uptake by specialized immune cells are essential to maintain host homeostasis. Phagosomes undergo fusion and fission events with endosomal and lysosomal compartments, a process called
Rudi Beyaert +2 more
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The NADPH Oxidase and the Phagosome
2020The key purpose of phagocytosis is the destruction of pathogenic microorganisms. The phagocytes exert a wide array of killing mechanisms that allow mastering the vast majority of pathogens. One of these mechanisms consists in the production of reactive oxygen species inside the phagosome by a specific enzyme, the phagocyte NADPH oxidase. This enzyme is
Hana, Valenta +3 more
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Measurement of phagosome-lysosome fusion and phagosomal pH
1994Publisher Summary Phagosome–lysosome fusion has been assessed by several different methods. Most of these strategies involve either the identification of endogenous lysosomal markers in organelles containing ingested organisms or the colocalization of the phagocytosed organism with an exogenous marker endocytosed by the cell and sequestered within ...
T H, Steinberg, J A, Swanson
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Chloroquine and the fungal phagosome
Current Opinion in Microbiology, 2000The antimalarial drug chloroquine accumulates inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C.
S M, Weber, S M, Levitz, T S, Harrison
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