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Intracellular Transformation of Phagosomes
Biology Bulletin, 2004The transformation of nascent phagosomes into forms capable of interacting with antimicrobial organelles of phagocytes, peroxisomes, depends on certain interactions between phagosomes and other vacuolar organelles. Phagosomes repeatedly interact with early and late endosomes through temporary contacts, which allows them to gain and lose complex sets of
P G, But +3 more
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Phagosome dynamics and function
BioEssays, 2000Phagocytosis of microorganisms and other particles is mediated most efficiently by receptors such as Fc-receptors (FcR) and complement-receptors (C3R). Interaction between these receptors and ligands on the particle results in signal transduction events that lead to actin polymerisation and phagosome formation. The phagosome then undergoes a maturation
T E, Tjelle, T, Lovdal, T, Berg
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2008
Autophagy and phagocytosis are evolutionarily ancient processes functioning in capture and digestion of material found in the cellular interior and exterior, respectively. In their most primordial form, both processes are involved in cellular metabolism and feeding, supplying cells with externally obtained particulate nutrients or using portions of ...
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Autophagy and phagocytosis are evolutionarily ancient processes functioning in capture and digestion of material found in the cellular interior and exterior, respectively. In their most primordial form, both processes are involved in cellular metabolism and feeding, supplying cells with externally obtained particulate nutrients or using portions of ...
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Rab GTPases Regulating Phagosome Maturation Are Differentially Recruited to Mycobacterial Phagosomes [PDF]
Traffic, 2011 Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that can replicate within infected macrophages. The ability of M. tb to arrest phagosome maturation is believed to facilitate its intracellular multiplication. Rab GTPases regulate membrane trafficking, but details of how Rab GTPases regulate phagosome maturation and how M ...
Yukio Koide
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Protoplasma, 1967
Lysosomes were first described as cell particles or granules. I am now inclined to call them vacuoles, even when they appear as compact bodies, in order to emphasize the essentially extracellular character of their contents. Together with the phagosomes, they form what is conveniently referred to as the vacuolarapparatus [1], an intracellular digestive
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Lysosomes were first described as cell particles or granules. I am now inclined to call them vacuoles, even when they appear as compact bodies, in order to emphasize the essentially extracellular character of their contents. Together with the phagosomes, they form what is conveniently referred to as the vacuolarapparatus [1], an intracellular digestive
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The phagosome proteome: insight into phagosome functions.
The Journal of cell biology, 2001Phagosomes are key organelles for the innate ability of macrophages to participate in tissue remodeling, clear apoptotic cells, and restrict the spread of intracellular pathogens. To understand the functions of phagosomes, we initiated the systematic identification of their proteins.
J, Garin +8 more
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2008
Electron microscopy (EM) is the only technique that can combine sensitive protein-detection methods with detailed information on the substructure of cellular compartments. The purpose of this chapter is to describe some of the methods at the EM level that can be used to analyze the spatial organization of cell organelles with respect to phagosomes or ...
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Electron microscopy (EM) is the only technique that can combine sensitive protein-detection methods with detailed information on the substructure of cellular compartments. The purpose of this chapter is to describe some of the methods at the EM level that can be used to analyze the spatial organization of cell organelles with respect to phagosomes or ...
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A Role for the Phagosome in Cytokine Secretion
Science, 2005Membrane traffic in activated macrophages is required for two critical events in innate immunity: proinflammatory cytokine secretion and phagocytosis of pathogens. We found a joint trafficking pathway linking both actions, which may economize membrane transport and augment the immune response. Tumor necrosis factor α (TNFα) is trafficked from the Golgi
Murray, R. Z. +3 more
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Characterization of the Mycobacterium tubercolosis phagosome
Journal of the American College of Cardiology, 1996Mycobacterium tuberculosis parasitizes host macrophages and resides in a phagosome that does not fuse with lysosomes and that resists acidification. Compared with phagosomes containing inert particles, the M. tuberculosis phagosome exhibits maturational arrest: plasma membrane proteins and early endocytic markers persist and there is limited ...
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The Journal of Protozoology, 1985
ABSTRACTThis study examines the relationship between phagosome acidification and phagosome‐lysosome fusion events using phagocytized Glugea hertwigi spores. The incidence of lysosome fusion with Glugea spores in phagosomes of mouse peritoneal macrophages and of Tetrahymena was monitored using colloidal gold and acridine orange as labels for secondary ...
E, Weidner, L D, Sibley
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ABSTRACTThis study examines the relationship between phagosome acidification and phagosome‐lysosome fusion events using phagocytized Glugea hertwigi spores. The incidence of lysosome fusion with Glugea spores in phagosomes of mouse peritoneal macrophages and of Tetrahymena was monitored using colloidal gold and acridine orange as labels for secondary ...
E, Weidner, L D, Sibley
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