Results 91 to 100 of about 22,892 (257)

Localization of Legionella bacteria within ribosome-studded phagosomes is not restricted to Legionella pneumophila [PDF]

, 2000
In this report, we investigate the intracellular fate of selected members of the genus Legionella within the monocytic cell line Mono Mac 6 cells. By means of electron microscopy and immunocytochemistry, we could show that Legionella pneumophila as well ...
M.J. Walz, Wolburg, H., H. Wolburg, H. Gerhardt, B. Neumeister, Walz, M.J., Faigle, M., H. Northoff, Gerhardt, H., Northoff, H., Neumeister, B., M. Faigle   +11 more
core   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Mycobacterium tuberculosis phagosome [PDF]

Molecular Microbiology, 1999
The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells.
Deretic, Vojo, Fratti, R. A.
openaire   +3 more sources

Interaction of phagosomes containing different phagocytic particles with MVB/Late endosomes. [PDF]

, 2012
LBPA acquisition was used to assess the interaction of phagosomes containing different particles with MVB/late endosomes. A) LBPA staining of a cell containing a LBPA-negative phagosome. B) Internalized agRBC stained with CFSE.
Luís M. B. B. Estronca (123414), Michelle S. Viegas (123409), Otília V. Vieira (5648932)   +2 more
core   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Mtb inhibits Hv1 recruitment to phagosomes. [PDF]

, 2018
The percentage of Mtb containing phagosomes that contain Hv1 was assessed in quadruplicate wells of Mtb infected BMDM by immunofluorescence at 1hr post-infection. Heat-killed H37Rv and M.
Miriam Braunstein (126550), Jonathan Tabb Sullivan (5155007), Katelyn E. Zulauf (5155004)   +2 more
core   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Lipid body-phagosome interaction in macrophages during infectious diseases: host defense or pathogen survival strategy? [PDF]

PLoS Pathogens, 2012
Phagocytosis of invading microorganisms by specialized cells such as macrophages and neutrophils is a key component of the innate immune response. These cells capture and engulf pathogens and subsequently destroy them in intracellular vacuoles-the ...
Rossana C N Melo, Ann M Dvorak
doaj   +1 more source

Mechanically induced actin-mediated rocketing of phagosomes [PDF]

, 2006
Actin polymerization can be induced in Dictyostelium by compressing the cells to bring phagosomes filled with large particles into contact with the plasma membrane. Asymmetric actin assembly results in rocketing movement of the phagosomes.
Muller-Taubenberger, Annette, Clarke, Margaret, Engel, Ulrike, Gerisch, Gunther, Clarke, M., Engel, U., Gerisch, G., Anderson, K., Muller-Taubenberger, A., Anderson, Kurt I   +9 more
core  

Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

Animal Models and Experimental Medicine, EarlyView.
We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin, Zichu Fu, Xuanxuan Zou, Senmao Chai, Jingjing Weng, Puqing Wang, Xiaodong Sun, Ming Sang   +7 more
wiley   +1 more source