Results 81 to 90 of about 22,892 (257)
Advanced Science, EarlyView.Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng +17 more
wiley +1 more source
A novel alpha kinase EhAK1 phosphorylates actin and regulates phagocytosis in Entamoeba histolytica.
PLoS Pathogens, 2014 Phagocytosis plays a key role in nutrient uptake and virulence of the protist parasite Entamoeba histolytica. Phagosomes have been characterized by proteomics, and their maturation in the cells has been studied.
M Shahid Mansuri +2 more
doaj +1 more source
Flow cytometric analysis of CFTR expression in neutrophils and phagosomes. [PDF]
, 2014 A) CFTR staining in neutrophils. Purified peripheral-blood neutrophils were immunostained for intracellular CFTR using the monoclonal CFTR antibody (mAb #660). Representative dot plots show that the neutrophils from Myeloid-Cftr−/− mice express CFTR (93%)
Craig A. Hodges (625155) +5 more
core +1 more source
Advanced Science, EarlyView.Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao +19 more
wiley +1 more source
PLoS ONE, 2012 Rab20, a member of the Rab GTPase family, is known to be involved in membrane trafficking, however its implication in FcγR-mediated phagocytosis is unclear.
Youhei Egami, Nobukazu Araki
doaj +1 more source
eLife, 2022 Autophagosomes are double-membrane intracellular vesicles that degrade protein aggregates, intracellular organelles, and other cellular components.
Omar Peña-Ramos +6 more
doaj +1 more source
The extraordinary phagosome [PDF]
Nature, 2002 The finding that a cellular compartment called the endoplasmic reticulum can merge with the cell's outer membrane is surprising. It would not have been predicted from our knowledge of cell organization.
openaire +1 more source
C. glabrata resides in non-matured macrophage phagosomes. [PDF]
, 2014 Representative DIC and fluorescence microscopy images of viable or heat killed C. glabrata 90 min post infection phagocytosed by human MDMs (left panels) showing marker proteins in red, while GFP-expressing C. glabrata are indicated in green.
Michael K. Mansour (557907) +16 more
core +1 more source
Advanced Science, EarlyView.This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng +7 more
wiley +1 more source
Rab GTPases Regulating Phagosome Maturation Are Differentially Recruited to Mycobacterial Phagosomes [PDF]
Traffic, 2011 Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that can replicate within infected macrophages. The ability of M. tb to arrest phagosome maturation is believed to facilitate its intracellular multiplication. Rab GTPases regulate membrane trafficking, but details of how Rab GTPases regulate phagosome maturation and how M ...
Shintaro, Seto +2 more
openaire +2 more sources