Results 71 to 80 of about 22,892 (257)

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Isolation of Phagosomes from Dendritic Cells by Using Magnetic Beads

Bio-Protocol, 2013
Phagosomes are intracellular organelles in dendritic cells in which pathogens such as viruses, bacteria and parasites are internalised to be proteolysed and killed.
Bénédicte Manoury
doaj   +1 more source

Kinetic Separation of Oxidative and Non-oxidative Metabolism in Single Phagosomes from Alveolar Macrophages: Impact on Bacterial Killing

iScience, 2020
Summary: The relative contribution of the two phagosomal catabolic processes, oxidative and metabolic, was assessed in the killing of Pseudomonas aeruginosa in phagosomes of alveolar macrophages (AMs) from wild-type (p47-phox+/+) or NOX-defective (p47 ...
Vladimir Riazanski, Zihao Sui, Deborah J. Nelson   +2 more
doaj   +1 more source

The Phagosome Proteome [PDF]

The Journal of Cell Biology, 2001
Phagosomes are key organelles for the innate ability of macrophages to participate in tissue remodeling, clear apoptotic cells, and restrict the spread of intracellular pathogens. To understand the functions of phagosomes, we initiated the systematic identification of their proteins.
Jérome Garin, Roberto Diez, Sylvie Kieffer, Jean-François Dermine, Sophie Duclos, Etienne Gagnon, Remy Sadoul, Christiane Rondeau, Michel Desjardins   +8 more
openaire   +1 more source

3-D quantitative tracking of phagosomes using quantitative phase microscopy [PDF]

, 2014
We present a method for quantitative tracking of phagosomes without labeling. Current imaging methods, used for phagosome research, have limitations in live-cell quantitative analysis.
Park, Yong Keun, Jung, Jae Hwang, Kim, Kyoohyun, YongKeun Park, Jonghee Yoon, Yoon, Jonghee, Kyoohyun Kim, Jaehwang Jung   +7 more
core   +1 more source

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, EarlyView.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

Phagocytosis is coupled to the formation of phagosome-associated podosomes and a transient disruption of podosomes in human macrophages

European Journal of Cell Biology, 2021
Phagocytosis consists in ingestion and digestion of large particles, a process strictly dependent on actin re-organization. Using synchronized phagocytosis of IgG-coated latex beads (IgG-LB), zymosan or serum opsonized-zymosan, we report the formation of
Margot Tertrais, Claire Bigot, Emmanuel Martin, Renaud Poincloux, Arnaud Labrousse, Isabelle Maridonneau-Parini   +5 more
doaj   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

SARS-CoV-2 Exploits Non-Canonical Autophagic Processes to Replicate, Mature, and Egress the Infected Vero E6 Cells

Pathogens, 2022
The coronavirus transforms the cytoplasm of susceptible cells to support virus replication. It also activates autophagy-like processes, the role of which is not well understood.
Juraj Koči, Marta Novotová, Monika Sláviková, Boris Klempa, Ivan Zahradník   +4 more
doaj   +1 more source