Results 101 to 110 of about 22,892 (257)

The macrophage microtubule network acts as a key cellular controller of the intracellular fate of Leishmania infantum.

PLoS Neglected Tropical Diseases, 2020
The parasitophorous vacuoles (PVs) that insulate Leishmania spp. in host macrophages are vacuolar compartments wherein promastigote forms differentiate into amastigote that are the replicative form of the parasite and are also more resistant to host ...
Sandrine Cojean, Valérie Nicolas, Vanessa Lievin-Le Moal   +2 more
doaj   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Identification of the phospholipid lysobisphosphatidic acid in the protozoan Entamoeba histolytica: An active molecule in endocytosis

Biochemistry and Biophysics Reports, 2016
Phospholipids are essential for vesicle fusion and fission and both are fundamental events for Entamoeba histolytica phagocytosis. Our aim was to identify the lysobisphosphatidic acid (LBPA) in trophozoites and investigate its cellular fate during ...
Silvia Castellanos-Castro, Carlos M. Cerda-García-Rojas, Rosario Javier-Reyna, Jonnatan Pais-Morales, Bibiana Chávez-Munguía, Esther Orozco   +5 more
doaj   +1 more source

Phagosomes from p110α knockdown cells show marked decreases in LAMP-1 acquisition and phagolysosome fusion. [PDF]

, 2013
A) Confocal microscopy of control and p110α knockdown cells shows reduced phagosomal LAMP-1 acquisition. The graph to the right shows counts of phagosomes colocalized with LAMP-1 staining.
Neil E. Reiner (89181), Emily P. Thi (176454), Ulrike Lambertz (176461)   +2 more
core   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics

Animal Research and One Health, EarlyView.
Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley   +1 more source

Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages.

PLoS ONE, 2014
Candida glabrata currently ranks as the second most frequent cause of invasive candidiasis. Our previous work has shown that C. glabrata is adapted to intracellular survival in macrophages and replicates within non-acidified late endosomal-stage ...
Lydia Kasper, Katja Seider, Franziska Gerwien, Stefanie Allert, Sascha Brunke, Tobias Schwarzmüller, Lauren Ames, Cristina Zubiria-Barrera, Michael K Mansour, Ulrike Becken, Dagmar Barz, Jatin M Vyas, Norbert Reiling, Albert Haas, Ken Haynes, Karl Kuchler, Bernhard Hube   +16 more
doaj   +1 more source

Actin and phosphoinositide recruitment to fully formed Candida albicans phagosomes in mouse macrophages. [PDF]

, 2009
Candida albicans is a dimorphic yeast that enters macrophages (Mphi) via the beta-glucan receptor dectin-1. Phagocytosis of C. albicans is characterized by actin polymerization, Syk kinase activation and rapid acquisition of phagolysosomal markers.
Taylor, Philip R., Gordon, S, Taylor, PR, Heinsbroek, SE, Kamen, Lynn A., Brown, GD, Kamen, LA, Gordon, Siamon, Heinsbroek, Sigrid E. M., Brown, Gordon D., Swanson, J, Swanson, Joel   +11 more
core   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Membrane proteomics of phagosomes suggests a connection to autophagy [PDF]

, 2008
Phagocytosis is the central process by which macrophage cells internalize and eliminate infectious microbes as well as apoptotic cells. During maturation, phagosomes containing engulfed particles fuse with various endosomal compartments through the ...
Shui, Wenqing
core   +3 more sources