Results 41 to 50 of about 22,892 (257)
Rab GTPases in Immunity and Inflammation
Frontiers in Cellular and Infection Microbiology, 2017 Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defenses.
Akriti Prashar +3 more
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Class IA phosphatidylinositol 3-kinase p110α regulates phagosome maturation. [PDF]
PLoS ONE, 2012 Of the various phosphatidylinositol 3- kinases (PI3Ks), only the class III enzyme Vps34 has been shown to regulate phagosome maturation. During studies of phagosome maturation in THP-1 cells deficient in class IA PI3K p110α, we discovered that this PI3K ...
Emily P Thi +2 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Understanding of how intracellular pathogens survive in their host cells is important to improve management of their diseases. This has been fruitful for intracellular bacteria, but it is an understudied area in fungal pathogens.
Emmanuel J. Santiago-Burgos +4 more
doaj +1 more source
Phagosome proteomes open the way to a better understanding of phagosome function [PDF]
Genome Biology, 2007 Phagocytic cells take up microbes and other particles into membrane-bounded organelles called phagosomes. Studies on the protein and lipid composition of model phagosomes containing latex beads are the first step in a systems-biology approach to understanding how these organelles function.
Griffiths, Gareth, Mayorga, Luis
openaire +2 more sources
Cell-free fusion of bacteria-containing phagosomes with endocytic compartments [PDF]
, 2010 Uptake of microorganisms by professional phagocytic cells leads to formation of a new subcellular compartment, the phagosome, which matures by sequential fusion with early and late endocytic compartments, resulting in oxidative and ...
Albert Haas +3 more
core +1 more source
EhVps32 Is a Vacuole-Associated Protein Involved in Pinocytosis and Phagocytosis of Entamoeaba histolytica. [PDF]
PLoS Pathogens, 2015 Here, we investigated the role of EhVps32 protein (a member of the endosomal-sorting complex required for transport) in endocytosis of Entamoeba histolytica, a professional phagocyte.
Yunuen Avalos-Padilla +7 more
doaj +1 more source
Francisella tularensisPhagosomal Escape Does Not Require Acidification of the Phagosome [PDF]
Infection and Immunity, 2009 ABSTRACTFollowing uptake,Francisella tularensisenters a phagosome that acquires limited amounts of lysosome-associated membrane glycoproteins and does not acquire cathepsin D or markers of secondary lysosomes. With additional time after uptake,F. tularensisdisrupts its phagosomal membrane and escapes into the cytoplasm.
Clemens, Daniel L +2 more
openaire +4 more sources
Interaction of phagosomes containing different phagocytic particles with lysosomes. [PDF]
, 2012 Before challenging SMC with phagocytic particles, these cells were incubated with Rhodamine-Dextran and then chased to label lysosomes as described in Experimental Procedures.
Luís M. B. B. Estronca (123414) +2 more
core +1 more source
Journal of Lipid Research, 1974 Polymorphonuclear leukocytes obtained from sterile peritoneal exudates in rabbits contain two phospholipid-splitting activities (phosphatidylacylhydrolases EC 3.1.1.4), one most active at pH 5.5 and the other between pH 7.2 and 9.0.
R. Franson, P. Patriarca, P. Elsbach
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Phagosomes contain the class IA PI3K p110α, and display PI(3,4,5)P3. [PDF]
, 2013 Phagosomes from p110αknockdown cells show decreased p110α recruitment and PI(3,4,5)3 levels. A)Phagosomes isolated from PMA-differentiated THP-1 cells contain the class IA PI3K p110α, and this is decreased in knockdown cells.
Neil E. Reiner (89181) +2 more
core +1 more source