Results 31 to 40 of about 20,078 (221)

Francisella tularensisPhagosomal Escape Does Not Require Acidification of the Phagosome [PDF]

Infection and Immunity, 2009
ABSTRACTFollowing uptake,Francisella tularensisenters a phagosome that acquires limited amounts of lysosome-associated membrane glycoproteins and does not acquire cathepsin D or markers of secondary lysosomes. With additional time after uptake,F. tularensisdisrupts its phagosomal membrane and escapes into the cytoplasm.
Clemens, Daniel L, Lee, Bai-Yu, Horwitz, Marcus A   +2 more
openaire   +4 more sources

Phospholipid metabolism by phagocytic cells. Phospholipases A2 associated with rabbit polymorphonuclear leukocyte granules

Journal of Lipid Research, 1974
Polymorphonuclear leukocytes obtained from sterile peritoneal exudates in rabbits contain two phospholipid-splitting activities (phosphatidylacylhydrolases EC 3.1.1.4), one most active at pH 5.5 and the other between pH 7.2 and 9.0.
R. Franson, P. Patriarca, P. Elsbach
doaj   +1 more source

EhVps32 Is a Vacuole-Associated Protein Involved in Pinocytosis and Phagocytosis of Entamoeaba histolytica. [PDF]

PLoS Pathogens, 2015
Here, we investigated the role of EhVps32 protein (a member of the endosomal-sorting complex required for transport) in endocytosis of Entamoeba histolytica, a professional phagocyte.
Yunuen Avalos-Padilla, Abigail Betanzos, Rosario Javier-Reyna, Guillermina García-Rivera, Bibiana Chávez-Munguía, Anel Lagunes-Guillén, Jaime Ortega, Esther Orozco   +7 more
doaj   +1 more source

Novel transmembrane receptor involved in phagosome transport of lysozymes and β-hexosaminidase in the enteric protozoan Entamoeba histolytica. [PDF]

PLoS Pathogens, 2012
Lysozymes and hexosaminidases are ubiquitous hydrolases in bacteria and eukaryotes. In phagocytic lower eukaryotes and professional phagocytes from higher eukaryotes, they are involved in the degradation of ingested bacteria in phagosomes.
Atsushi Furukawa, Kumiko Nakada-Tsukui, Tomoyoshi Nozaki   +2 more
doaj   +1 more source

Determinants of Phagosomal pH During Host-Pathogen Interactions

Frontiers in Cell and Developmental Biology, 2021
The ability of phagosomes to halt microbial growth is intimately linked to their ability to acidify their luminal pH. Establishment and maintenance of an acidic lumen requires precise co-ordination of H+ pumping and counter-ion permeation to offset the ...
Johannes Westman, Sergio Grinstein, Sergio Grinstein   +2 more
doaj   +1 more source

The Burkholderia pseudomallei type III secretion system and BopA are required for evasion of LC3-associated phagocytosis.

PLoS ONE, 2011
Burkholderia pseudomallei is the causative agent of melioidosis, a fatal infectious disease endemic in tropical regions worldwide, and especially prevalent in southeast Asia and northern Australia.
Lan Gong, Meabh Cullinane, Puthayalai Treerat, Georg Ramm, Mark Prescott, Ben Adler, John D Boyce, Rodney J Devenish   +7 more
doaj   +1 more source

The Formation and Renewal of Photoreceptor Outer Segments

Cells
The visual system is essential for humans to perceive the environment. In the retina, rod and cone photoreceptor neurons are the initial sites where vision forms.
Jingjin Xu, Chengtian Zhao, Yunsi Kang
doaj   +1 more source

Frustrated phagocytosis on micro-patterned immune complexes to characterize lysosome movements in live macrophages.

Frontiers in Immunology, 2011
Lysosome mobilization is a key cellular process in phagocytes for bactericidal activities and trans-matrix migration. The molecular mechanisms that regulate lysosome mobilization are still poorly known.
Arnaud M. Labrousse, Etienne eMeunier, Julien eRecord, Anna eLabernadie, Anna eLabernadie, Amélie eBeduer, Christophe eVieu, Thouraya eBen Safta, Isabelle eMaridonneau-Parini   +8 more
doaj   +1 more source

Anisotropic presentation of ligands on cargos modulates degradative function of phagosomes

Biophysical Reports, 2022
Anisotropic arrangement of cell wall components is ubiquitous among bacteria and fungi, but how such functional anisotropy affects interactions between microbes and host immune cells is not known.
Mengchi Jiao, Wenqian Li, Yanqi Yu, Yan Yu   +3 more
doaj   +1 more source

Redox-sensitive probes for the measurement of redox chemistries within phagosomes of macrophages and dendritic cells

Redox Biology, 2013
There is currently much interest in factors that affect redox chemistries within phagosomes of macrophages and dendritic cells. In addition to the antimicrobial role of reactive oxygen species generation within phagosomes, accumulating evidence suggests ...
Dale R. Balce, Robin M. Yates
doaj   +1 more source