Results 31 to 40 of about 22,892 (257)
mBio, 2018 Intracellular pathogens have varied strategies to breach the endolysosomal barrier so that they can deliver effectors to the host cytosol, access nutrients, replicate in the cytoplasm, and avoid degradation in the lysosome.
Ekansh Mittal +7 more
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Bio-Protocol, 2022 During an animal's development, a large number of cells undergo apoptosis, a suicidal form of death. These cells are promptly phagocytosed by other cells and degraded inside phagosomes.
Omar Peña-Ramos, Zheng Zhou
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The Mycobacterium tuberculosis Phagosome [PDF]
, 2008 Tuberculosis is currently the most devastating human bacterial disease, causing millions of deaths annually and infecting an overwhelming percentage of the global population. Its success as a scourge lies in the ability of Mycobacterium tuberculosis to prevent normal phagolysosome biogenesis, essential to the destruction of invading microorganisms ...
Esteban A, Roberts, Vojo, Deretic
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TRPC6 channel translocation into phagosomal membrane augments phagosomal function [PDF]
Proceedings of the National Academy of Sciences, 2015 SignificanceHistorically, pulmonary infections treated with antibiotics killed bacteria while selecting for the unintended development of pathogenic resistance. One strategy to circumvent antibiotic resistance in pulmonary infection involves targeting the host phagosome and augmenting its function.
Riazanski, Vladimir +19 more
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SWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis
Cell Reports, 2016 Actin plays a critical role during the early stages of pathogenic microbe internalization by immune cells. In this study, we identified a key mechanism of actin filament tethering and stabilization to the surface of phagosomes in human dendritic cells ...
Maksim V. Baranov +6 more
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Analysis of phagosomal proteomes: From latex‐bead to bacterial phagosomes [PDF]
PROTEOMICS, 2010 Abstract Phagosomal proteome characterization has contributed significantly to the understanding of host–pathogen interaction and the mechanism of infectious diseases caused by intracellular bacteria. The latex bead‐containing phagosome has been widely used as a model system to study phagosomal proteomes at a global level. In contrast,
Qingbo, Li +4 more
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Flotillin-1-enriched lipid raft domains accumulate on maturing phagosomes [PDF]
, 2001 Flotillin-1 was recently shown to be enriched on detergent-resistant domains of the plasma membrane called lipid rafts. These rafts, enriched in sphingolipids and cholesterol, sequester certain proteins while excluding others.
Parton, R. G. +6 more
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Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells. [PDF]
PLoS Biology, 2012 Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a signaling molecule important for many membrane trafficking events, including phagosome maturation. The level of PtdIns(3)P on phagosomes oscillates in two waves during phagosome maturation.
Nan Lu +5 more
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The macrophage marches on its phagosome: dynamic assays of phagosome function [PDF]
Nature Reviews Immunology, 2009 Professional phagocytes ingest particulate material to fulfil a diverse array of functions in a multicellular organism. The ancestral function of phagosomes is digestion; however, through evolution this degradative capacity has become pivotal to the adaptive immune response by processing antigens to be presented to lymphocytes.
Russell, David G +4 more
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Phagosomes Exhibit Arrested Maturation despite Acquisition of Rab7 [PDF]
, 2000 Rab7 is a small GTPase that regulates vesicular traffic from early to late endosomal stages of the endocytic pathway. Phagosomes containing inert particles have also been shown to transiently acquire Rab7 as they mature.
Horwitz, MA +5 more
core +1 more source