Results 11 to 20 of about 22,892 (257)

Antimicrobial Activity of Neutrophils Against Mycobacteria

Frontiers in Immunology, 2021
The mycobacterium genus contains a broad range of species, including the human pathogens M. tuberculosis and M. leprae. These bacteria are best known for their residence inside host cells.
Heather A. Parker, Lorna Forrester, Christopher D. Kaldor, Nina Dickerhof, Mark B. Hampton   +4 more
doaj   +1 more source

Osmotically Rupturing Phagosomes in Macrophages Using PNIPAM Microparticles [PDF]

, 2023
The rupture of macrophage phagosomes has been implicated in various human diseases and plays a critical role in immunity. However, the mechanisms underlying this process are complex and not yet fully understood.
Masahiro Fukuda (5348687), Yuan Liu (88411), Christina Holmes (15471302), Jingjiao Guan (1636078), Yi Ren (30049), Sundol Kim (7456508), Yan Li (23143), Hoyong Chung (2010178), Wenhao Cheng (6741377), Xingchi Chen (6090260)   +9 more
core   +3 more sources

Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection

Microbiology Spectrum, 2023
Phagolysosomes are crucial organelles during the elimination of pathogens by host cells. The maintenance of their membrane integrity is vital during stressful conditions, such as during Candida albicans infection.
Beatriz Cristovao, Lisa Rodrigues, Steve Catarino, Monica Abreu, Teresa Gonçalves, Neuza Domingues, Henrique Girao   +6 more
doaj   +1 more source

Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection

mBio, 2023
There is a limited understanding of host defense mechanisms targeting intracellular pathogens that proliferate in a lysosome. Coxiella burnetii is a model bacterial pathogen capable of replicating in the hydrolytic and acidic environment of the lysosome.
Sandhya Ganesan, Natalie N. Alvarez, Samuel Steiner, Karen M. Fowler, Abigail K. Corona, Craig R. Roy   +5 more
doaj   +1 more source

DRAM1 Promotes Lysosomal Delivery of Mycobacterium marinum in Macrophages

Cells, 2023
Damage-Regulated Autophagy Modulator 1 (DRAM1) is an infection-inducible membrane protein, whose function in the immune response is incompletely understood.
Adrianna Banducci-Karp, Jiajun Xie, Sem A. G. Engels, Christos Sarantaris, Patrick van Hage, Monica Varela, Annemarie H. Meijer, Michiel van der Vaart   +7 more
doaj   +1 more source

Metabolism of Gluconeogenic Substrates by an Intracellular Fungal Pathogen Circumvents Nutritional Limitations within Macrophages

mBio, 2020
Microbial pathogens exploit host nutrients to proliferate and cause disease. Intracellular pathogens, particularly those exclusively living in the phagosome such as Histoplasma capsulatum, must adapt and acquire nutrients within the nutrient-limited ...
Qian Shen, Stephanie C. Ray, Heather M. Evans, George S. Deepe, Chad A. Rappleye   +4 more
doaj   +1 more source

Correction: A subset of neutrophil phagosomes is characterised by pulses of Class I PI3K activity. [PDF]

Dis Model Mech
Class I PI3kinases coordinate the delivery of microbicidal effectors to the phagosome by forming phosphatidylinositol (3, 4, 5)-trisphosphate (PIP3). However, the dynamics of PIP3 in neutrophils during a live bacterial tissue infection are unknown.
Muir CF, Reyes-Aldasoro CC, Prajsnar TK, Michno BJ, Cholewa-Waclaw J, Ho YX, Bernut A, Loynes CA, Elworthy S, Bowden KA, Cadby AJ, Prince LR, King JS, Ellett F, Condliffe AM, Renshaw SA.   +15 more
europepmc   +3 more sources

Microtubule Motor Transport of Organelles in a Specialized Epithelium: The RPE

Frontiers in Cell and Developmental Biology, 2022
The retinal pigment epithelium (RPE) is a uniquely polarized epithelium that lies adjacent to the photoreceptor cells in the retina, and is essential for photoreceptor function and viability.
Roni A. Hazim, David S. Williams, David S. Williams, David S. Williams, David S. Williams   +4 more
doaj   +1 more source

Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases

Cells, 2018
Chronic degeneration of the Retinal Pigment Epithelium (RPE) is a precursor to pathological changes in the outer retina. The RPE monolayer, which lies beneath the neuroretina, daily internalises and digests large volumes of spent photoreceptor outer ...
Eloise Keeling, Andrew J. Lotery, David A. Tumbarello, J. Arjuna Ratnayaka   +3 more
doaj   +1 more source

Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice [PDF]

, 2009
The small GTPase Rab5 is a key regulator of endosome/phagosome maturation and in intravesicular infections marks a phagosome stage at which decisions over pathogen replication or destruction are integrated.
Paape, Daniel, Blackburn, Clare, Lippuner, C., Smith, Andrew, Smith, A. J., Paterou, A., Brand, J., Richardson, Melville, Richardson, M., Blackburn, C., Andrew J. Smith, Volker Brinkmann, Brinkmann, Volker, Janko Brand, Smith, A., Brinkmann, V., Daniel Paape, Toni Aebischer, Brand, Janko, Hoffmann, Kirstin, Hoffmann, K., Athina Paterou, Kirstin Hoffmann, Aebischer, Toni, Paterou, Athina, Paape, D., Clare Blackburn, Smith, Andrew J., Melville Richardson, Aebischer, T., Christoph Lippuner, Lippuner, Christoph   +31 more
core   +1 more source