Results 11 to 20 of about 20,078 (221)

Phagosomal transport depends strongly on phagosome size [PDF]

Scientific Reports, 2017
AbstractMacrophages internalize pathogens for intracellular degradation. An important part of this process is the phagosomal transport from the cell periphery to the perinuclear region. Biochemical factors are known to influence the fate of phagosomes. Here, we show that the size of phagosomes also has a strong influence on their transport.
Keller, S., Berghoff, K., Kress, H.
openaire   +4 more sources

The Lipid Raft-Associated Protein Stomatin Is Required for Accumulation of Dectin-1 in the Phagosomal Membrane and for Full Activity of Macrophages against Aspergillus fumigatus

mSphere, 2023
Alveolar macrophages belong to the first line of defense against inhaled conidia of the human-pathogenic fungus Aspergillus fumigatus. In lung alveoli, they contribute to phagocytosis and elimination of conidia.
Marie Goldmann, Franziska Schmidt, Zoltán Cseresnyés, Thomas Orasch, Susanne Jahreis, Susann Hartung, Marc Thilo Figge, Marie von Lilienfeld-Toal, Thorsten Heinekamp, Axel A. Brakhage   +9 more
doaj   +1 more source

Alteraciones en el reclutamiento y activación de proteínas Rab durante la infección micobacteriana

Biomédica: revista del Instituto Nacional de Salud, 2010
En el fagosoma, Mycobacterium spp. altera la activación y reclutamiento de diferentes proteínas "del gen Ras de cerebro de rata", comúnmente conocidas como Rab.
Diana Castaño, Mauricio Rojas
doaj   +1 more source

Proteomic analysis of Atg8-dependent recruitment of phagosomal proteins in the enteric protozoan parasite Entamoeba histolytica

Frontiers in Cellular and Infection Microbiology, 2022
Autophagy is one of the bulk degradation systems and is conserved throughout eukaryotes. In the enteric protozoan parasite Entamoeba histolytica, the causative agent of human amebiasis, Atg8 is not exclusively involved in autophagy per se but also in ...
Kumiko Nakada-Tsukui, Natsuki Watanabe, Kumiko Shibata, Ratna Wahyuni, Eri Miyamoto, Tomoyoshi Nozaki   +5 more
doaj   +1 more source

Endosomal and Phagosomal SNAREs [PDF]

Physiological Reviews, 2018
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein family is of vital importance for organelle communication. The complexing of cognate SNARE members present in both the donor and target organellar membranes drives the membrane fusion required for intracellular transport.
Ilse Dingjan, Peter T. A. Linders, Danielle R. J. Verboogen, Natalia H. Revelo, Martin ter Beest, Geert van den Bogaart   +5 more
openaire   +4 more sources

N-Acetylglucosamine Metabolism Promotes Survival of Candida albicans in the Phagosome

mSphere, 2017
Phagocytosis by innate immune cells is one of the most effective barriers against the multiplication and dissemination of microbes within the mammalian host.
Elisa M. Vesely, Robert B. Williams, James B. Konopka, Michael C. Lorenz   +3 more
doaj   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Human Monocyte-Derived Dendritic Cells Produce Millimolar Concentrations of ROS in Phagosomes Per Second

Frontiers in Immunology, 2019
Neutrophils kill ingested pathogens by the so-called oxidative burst, where reactive oxygen species (ROS) are produced in the lumen of phagosomes at very high rates (mM/s), although these rates can only be maintained for a short period (minutes).
Laurent M. Paardekooper, Ilse Dingjan, Ilse Dingjan, Peter T. A. Linders, Alexander H. J. Staal, Simona M. Cristescu, Wilco C. E. P. Verberk, Geert van den Bogaart, Geert van den Bogaart   +8 more
doaj   +1 more source

Monitoring the Recruitment and Fusion of Autophagosomes to Phagosomes During the Clearance of Apoptotic Cells in the Nematode Caenorhabditis elegans

Bio-Protocol, 2022
During an animal's development, a large number of cells undergo apoptosis, a suicidal form of death. These cells are promptly phagocytosed by other cells and degraded inside phagosomes.
Omar Peña-Ramos, Zheng Zhou
doaj   +1 more source

Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response

mBio, 2018
Intracellular pathogens have varied strategies to breach the endolysosomal barrier so that they can deliver effectors to the host cytosol, access nutrients, replicate in the cytoplasm, and avoid degradation in the lysosome.
Ekansh Mittal, Michael L. Skowyra, Grace Uwase, Emir Tinaztepe, Alka Mehra, Stefan Köster, Phyllis I. Hanson, Jennifer A. Philips   +7 more
doaj   +1 more source